73 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	hgf-2	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
	Magi2.L	PDZ domain-containing protein. (104 aa)
	hgf	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
	Magi2.S	Uncharacterized protein. (1117 aa)
	map2k1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)
	Rho.L	Rhodopsin. (459 aa)
	patj	Uncharacterized protein. (1796 aa)
	cdh3	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
	cdh1	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (871 aa)
	Cdh3.S	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (880 aa)
	pxdn-2	Uncharacterized protein. (1464 aa)
	Prkci.L	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (588 aa)
	cldn1	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	fyn	Tyrosine-protein kinase. (537 aa)
	pxdn	Uncharacterized protein. (1461 aa)
	lyn-2	Tyrosine-protein kinase. (508 aa)
	Rock1.L	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1360 aa)
	Dsp.L	Uncharacterized protein. (2802 aa)
	lyn	Tyrosine-protein kinase. (508 aa)
	cdh2	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (947 aa)
	Rock1.S	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1367 aa)
	esam	Ig-like domain-containing protein. (438 aa)
	Ctnnd1.L	Uncharacterized protein. (248 aa)
	Cdk1.L	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (333 aa)
	cdk1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
	cgn-2	Myosin_tail_1 domain-containing protein. (1368 aa)
	Prkch.L	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (691 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	cldn2	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (231 aa)
	cgn	Myosin_tail_1 domain-containing protein. (1368 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	tnf	TNF_2 domain-containing protein. (227 aa)
	sympk	Uncharacterized protein. (1202 aa)
	A0A1L8F270	FERM domain-containing protein. (580 aa)
	Hgs.L	Uncharacterized protein. (749 aa)
	hck	Tyrosine-protein kinase. (496 aa)
	src	Tyrosine-protein kinase. (532 aa)
	rac1	MGC114731 protein. (192 aa)
	prkaa1	Non-specific serine/threonine protein kinase. (560 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	pik3r3	MGC84470 protein. (461 aa)
	cldn5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa)
	ptpn11b	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	pik3r1	MGC80357 protein. (722 aa)
	cav1a	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
	cldn5-2	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa)
	mal	MGC68692 protein. (159 aa)
	yes1	Tyrosine-protein kinase. (537 aa)
	rhoa	MGC64296 protein. (193 aa)
	tjp3-2	MGC52795 protein; Belongs to the MAGUK family. (1010 aa)
	flt1	Vegf-B-prov protein. (687 aa)
	actl6a	Baf53a-pending-prov protein; Belongs to the actin family. (429 aa)
	cldn1-2	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (560 aa)
	Ptpn11.S	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
	rac3	RAC1 protein. (192 aa)
	mapk14	Mitogen-activated protein kinase. (361 aa)
	fyn-2	Tyrosine-protein kinase. (537 aa)
	PIK3R1	Phosphoinositide-3-kinase. (722 aa)
	tnf-2	Tumor necrosis factor alpha. (225 aa)
	Marveld3.L	MARVEL domain-containing protein. (215 aa)
	pik3c3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (886 aa)
	tjp3	Uncharacterized protein; Belongs to the MAGUK family. (1025 aa)
	Tjp2.L	Uncharacterized protein. (430 aa)
	vegfc	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (402 aa)
	Vegfc.S	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (407 aa)
	A0A1L8HJ91	FERM domain-containing protein. (557 aa)
	Lck.L	Tyrosine-protein kinase. (502 aa)
	Vegfd.L	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (306 aa)
	rdx	FERM domain-containing protein. (602 aa)
	lck	Tyrosine-protein kinase. (503 aa)
	Tjp1.S	Uncharacterized protein; Belongs to the MAGUK family. (1705 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8F270	A0A1L8HJ91	A0A1L8F270	A0A1L8HJ91	FERM domain-containing protein.	FERM domain-containing protein.	0.957
A0A1L8F270	Cdh3.S	A0A1L8F270	A0A1L8GET9	FERM domain-containing protein.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.501
A0A1L8F270	Hgs.L	A0A1L8F270	A0A1L8ETK7	FERM domain-containing protein.	Uncharacterized protein.	0.449
A0A1L8F270	Prkci.L	A0A1L8F270	A0A1L8GAK2	FERM domain-containing protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.412
A0A1L8F270	Rock1.L	A0A1L8F270	A0A1L8FYP1	FERM domain-containing protein.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.426
A0A1L8F270	Rock1.S	A0A1L8F270	A0A1L8FSV4	FERM domain-containing protein.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.426
A0A1L8F270	Tjp1.S	A0A1L8F270	A0A1L8H090	FERM domain-containing protein.	Uncharacterized protein; Belongs to the MAGUK family.	0.410
A0A1L8F270	actl6a	A0A1L8F270	Q7ZYI5	FERM domain-containing protein.	Baf53a-pending-prov protein; Belongs to the actin family.	0.978
A0A1L8F270	cdh1	A0A1L8F270	A0A1L8GKV4	FERM domain-containing protein.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.500
A0A1L8F270	cdh3	A0A1L8F270	A0A1L8GKW6	FERM domain-containing protein.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.499
A0A1L8F270	ctnnb1	A0A1L8F270	Q63ZT4	FERM domain-containing protein.	Beta-catenin protein.	0.447
A0A1L8F270	patj	A0A1L8F270	A0A1L8GLZ0	FERM domain-containing protein.	Uncharacterized protein.	0.418
A0A1L8F270	rac1	A0A1L8F270	Q58E25	FERM domain-containing protein.	MGC114731 protein.	0.636
A0A1L8F270	rac3	A0A1L8F270	Q9PW31	FERM domain-containing protein.	RAC1 protein.	0.509
A0A1L8F270	rdx	A0A1L8F270	A0A1L8HAW1	FERM domain-containing protein.	FERM domain-containing protein.	0.957
A0A1L8F270	rhoa	A0A1L8F270	Q7SZA9	FERM domain-containing protein.	MGC64296 protein.	0.691
A0A1L8F270	src	A0A1L8F270	Q2TAR1	FERM domain-containing protein.	Tyrosine-protein kinase.	0.525
A0A1L8HJ91	A0A1L8F270	A0A1L8HJ91	A0A1L8F270	FERM domain-containing protein.	FERM domain-containing protein.	0.957
A0A1L8HJ91	Hgs.L	A0A1L8HJ91	A0A1L8ETK7	FERM domain-containing protein.	Uncharacterized protein.	0.449
A0A1L8HJ91	Prkci.L	A0A1L8HJ91	A0A1L8GAK2	FERM domain-containing protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.566