63 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Tp53.L	P53 domain-containing protein. (137 aa)
	calml4-2	Uncharacterized protein. (152 aa)
	mdm2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (489 aa)
	rad50-2	Zinc-hook domain-containing protein. (1312 aa)
	skp1-2	Uncharacterized protein; Belongs to the SKP1 family. (221 aa)
	rad50	Zinc-hook domain-containing protein. (1311 aa)
	calml4	Uncharacterized protein. (153 aa)
	skp1	Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
	Cdkn1b.S	Uncharacterized protein. (152 aa)
	Rad26	Uncharacterized protein. (798 aa)
	ccne1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (408 aa)
	atrip	Uncharacterized protein. (801 aa)
	Ccne1.S	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (408 aa)
	Phlpp2.S	PPM-type phosphatase domain-containing protein. (1179 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	xpo1	Importin N-terminal domain-containing protein. (1071 aa)
	plek	Uncharacterized protein. (350 aa)
	calm1	Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
	Prkdc.L	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (4146 aa)
	Rbbp8.L	Uncharacterized protein. (856 aa)
	egfr-2	Receptor protein-tyrosine kinase. (1210 aa)
	topbp1	Uncharacterized protein. (1573 aa)
	Myc.S	Myc_N domain-containing protein. (176 aa)
	rbbp8	Uncharacterized protein. (846 aa)
	egfr	Receptor protein-tyrosine kinase. (1208 aa)
	A0A1L8FND1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
	chek1-2	Protein kinase domain-containing protein. (510 aa)
	Cdk1.L	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (333 aa)
	chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
	cdk1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
	akt2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (486 aa)
	e2f1	E2F_TDP domain-containing protein. (427 aa)
	Brca1.L	Uncharacterized protein. (1582 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	klf9	Basic transcription element binding protein 1. (292 aa)
	Hus1	Checkpoint protein; Belongs to the HUS1 family. (282 aa)
	ccnd1	Ccnd1-prov protein; Belongs to the cyclin family. (291 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
	rpls3-b	Rpls3-b protein; Belongs to the universal ribosomal protein uS3 family. (246 aa)
	xpo1-2	Xpo1 protein. (1071 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	mapkapk2	MGC78852 protein; Belongs to the protein kinase superfamily. (377 aa)
	ccna2	MGC130969 protein; Belongs to the cyclin family. (415 aa)
	cdkn2b-2	MGC154405 protein. (125 aa)
	Clspn.S	Claspin. (1286 aa)
	ins-2	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	cdc25b	Cdc25B phosphatase. (562 aa)
	pten	Phosphatase and tensin homolog S homeolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
	e2f1-2	LOC100036852 protein. (426 aa)
	Skp2.L	F-box domain-containing protein. (420 aa)
	Chek2.L	Uncharacterized protein. (392 aa)
	cdkn2b	ANK_REP_REGION domain-containing protein. (125 aa)
	Ccna2.S	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (415 aa)
	rps3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (246 aa)
	Ccna1.L	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (421 aa)
	Hspb1.L	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (272 aa)
	rps6kb1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (521 aa)
	A0A1L8HBL4	ANK_REP_REGION domain-containing protein. (263 aa)
	Ccna1.S	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (418 aa)
	Cdk2.S	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
	Hspb1.S	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (263 aa)
	Rps6kb1.S	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
	Mdm4.S	RanBP2-type domain-containing protein. (423 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FND1	Brca1.L	A0A1L8FND1	A0A1L8ETS4	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.405
A0A1L8FND1	Cdkn1b.S	A0A1L8FND1	A0A1L8GQW1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.433
A0A1L8FND1	Myc.S	A0A1L8FND1	A0A1L8FTW7	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Myc_N domain-containing protein.	0.575
A0A1L8FND1	Rps6kb1.S	A0A1L8FND1	A0A1L8H7Z6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.679
A0A1L8FND1	Tp53.L	A0A1L8FND1	A0A1L8H4M6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	P53 domain-containing protein.	0.703
A0A1L8FND1	akt2	A0A1L8FND1	A0A1L8F8Y4	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.654
A0A1L8FND1	calm1	A0A1L8FND1	A0A1L8G5X8	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein; Belongs to the calmodulin family.	0.689
A0A1L8FND1	calml4	A0A1L8FND1	A0A1L8GSE0	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.693
A0A1L8FND1	calml4-2	A0A1L8FND1	A0A1L8H184	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.693
A0A1L8FND1	ccnd1	A0A1L8FND1	Q8AVQ4	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Ccnd1-prov protein; Belongs to the cyclin family.	0.617
A0A1L8FND1	egfr	A0A1L8FND1	A0A1L8FRS8	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Receptor protein-tyrosine kinase.	0.876
A0A1L8FND1	egfr-2	A0A1L8FND1	A0A1L8FWP8	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Receptor protein-tyrosine kinase.	0.876
A0A1L8FND1	ins	A0A1L8FND1	A0A1L8GD41	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.907
A0A1L8FND1	ins-2	A0A1L8FND1	B7ZQP1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.905
A0A1L8FND1	myc	A0A1L8FND1	Q6NRN4	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.646
A0A1L8FND1	plek	A0A1L8FND1	A0A1L8G6R7	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.515
A0A1L8FND1	pten	A0A1L8FND1	A1L2J3	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Phosphatase and tensin homolog S homeolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.691
A0A1L8FND1	rps6kb1	A0A1L8FND1	A0A1L8HFU6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.679
A0A1L8HBL4	akt2	A0A1L8HBL4	A0A1L8F8Y4	ANK_REP_REGION domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.942
A0A1L8HBL4	mapkapk2	A0A1L8HBL4	Q6IRB4	ANK_REP_REGION domain-containing protein.	MGC78852 protein; Belongs to the protein kinase superfamily.	0.450