51 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Flt1.S	Uncharacterized protein. (683 aa)
	bmp4-2	Bone morphogenetic protein 4. (400 aa)
	creb1	Creb1-prov protein. (324 aa)
	actl6a	Baf53a-pending-prov protein; Belongs to the actin family. (429 aa)
	flt1	Vegf-B-prov protein. (687 aa)
	nkx2-5-2	Nkx2.5 protein. (299 aa)
	klf17	Biklf-A protein. (413 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	gata4-2	MGC81427 protein. (394 aa)
	pecam1-2	Platelet endothelial cell adhesion molecule. (727 aa)
	vegfa	Vascular endothelial growth factor 196; Belongs to the PDGF/VEGF growth factor family. (194 aa)
	tbx5-2	T-box transcription factor Tbx5. (519 aa)
	bmp4	Bone morphogenetic protein 4. (401 aa)
	admp2	Anti-dorsalizing morphogenetic protein-2. (400 aa)
	mef2c-2	MADS-box domain-containing protein. (464 aa)
	Lox.L	Uncharacterized protein. (457 aa)
	Klf4	Uncharacterized protein. (454 aa)
	pdgfra-2	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1087 aa)
	Kit.L	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
	oxt-2	Uncharacterized protein; Belongs to the vasopressin/oxytocin family. (125 aa)
	mef2c	MADS-box domain-containing protein. (464 aa)
	lox	Uncharacterized protein. (422 aa)
	tbx5	Uncharacterized protein. (519 aa)
	Myh6.S	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1934 aa)
	tek	Uncharacterized protein. (1126 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	pdgfra	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
	kdr	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1326 aa)
	Kit.S	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (963 aa)
	Sox2.S	HMG box domain-containing protein. (194 aa)
	pecam1	Uncharacterized protein. (684 aa)
	Myh11.S	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1979 aa)
	Cebpb.L	CCAAT/enhancer-binding protein. (281 aa)
	glb1	Uncharacterized protein; Belongs to the glycosyl hydrolase 35 family. (642 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	Pou5f3.1	POU domain protein. (445 aa)
	pou5f3.2	POU domain protein. (449 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	Glb1l2.S	Beta-galactosidase. (616 aa)
	glb1l2	Beta-galactosidase. (634 aa)
	Glb1l.L	Beta-galactosidase. (645 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
	bmp2	TGF_BETA_2 domain-containing protein. (398 aa)
	gata4	Uncharacterized protein. (392 aa)
	Bmp2.L	TGF_BETA_2 domain-containing protein. (398 aa)
	tgfb2-2	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
	cdh5	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (774 aa)
	cdh5-2	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (775 aa)
	nkx2-5	Homeobox domain-containing protein. (300 aa)
	A0A1L8H8G6	Uncharacterized protein. (114 aa)
	oxt	Uncharacterized protein; Belongs to the vasopressin/oxytocin family. (125 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8H8G6	actl6a	A0A1L8H8G6	Q7ZYI5	Uncharacterized protein.	Baf53a-pending-prov protein; Belongs to the actin family.	0.945
Bmp2.L	Sox2.S	A0A1L8G5P4	A0A1L8EK54	TGF_BETA_2 domain-containing protein.	HMG box domain-containing protein.	0.498
Bmp2.L	admp2	A0A1L8G5P4	A1E8I5	TGF_BETA_2 domain-containing protein.	Anti-dorsalizing morphogenetic protein-2.	0.902
Bmp2.L	bmp2	A0A1L8G5P4	A0A1L8G1N2	TGF_BETA_2 domain-containing protein.	TGF_BETA_2 domain-containing protein.	0.900
Bmp2.L	fgf2	A0A1L8G5P4	A0A1L8HLX5	TGF_BETA_2 domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.553
Bmp2.L	gata4	A0A1L8G5P4	A0A1L8G5M0	TGF_BETA_2 domain-containing protein.	Uncharacterized protein.	0.633
Bmp2.L	gata4-2	A0A1L8G5P4	Q6GR12	TGF_BETA_2 domain-containing protein.	MGC81427 protein.	0.633
Bmp2.L	kdr	A0A1L8G5P4	A0A1L8HLA0	TGF_BETA_2 domain-containing protein.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.461
Bmp2.L	myc	A0A1L8G5P4	Q6NRN4	TGF_BETA_2 domain-containing protein.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.424
Bmp2.L	nkx2-5	A0A1L8G5P4	A0A1L8GXU4	TGF_BETA_2 domain-containing protein.	Homeobox domain-containing protein.	0.677
Bmp2.L	nkx2-5-2	A0A1L8G5P4	Q7T0T3	TGF_BETA_2 domain-containing protein.	Nkx2.5 protein.	0.670
Bmp2.L	tbx5	A0A1L8G5P4	A0A1L8HPY2	TGF_BETA_2 domain-containing protein.	Uncharacterized protein.	0.583
Bmp2.L	tbx5-2	A0A1L8G5P4	B7ZRZ7	TGF_BETA_2 domain-containing protein.	T-box transcription factor Tbx5.	0.582
Bmp2.L	vegfa	A0A1L8G5P4	O42572	TGF_BETA_2 domain-containing protein.	Vascular endothelial growth factor 196; Belongs to the PDGF/VEGF growth factor family.	0.507
Cebpb.L	Klf4	A0A1L8ESS1	A0A1L8HY83	CCAAT/enhancer-binding protein.	Uncharacterized protein.	0.508
Cebpb.L	creb1	A0A1L8ESS1	Q8AVY5	CCAAT/enhancer-binding protein.	Creb1-prov protein.	0.716
Cebpb.L	klf17	A0A1L8ESS1	Q7SZU5	CCAAT/enhancer-binding protein.	Biklf-A protein.	0.493
Cebpb.L	myc	A0A1L8ESS1	Q6NRN4	CCAAT/enhancer-binding protein.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.437
Flt1.S	cdh5	A0A1L8HAK5	A0A1L8GEW5	Uncharacterized protein.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.612
Flt1.S	cdh5-2	A0A1L8HAK5	A0A1L8GKR1	Uncharacterized protein.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.612