68 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pecam1	Uncharacterized protein. (684 aa)
	Nfatc2.S	RHD domain-containing protein. (884 aa)
	A0A1L8ENI4	Uncharacterized protein. (815 aa)
	fzd5	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
	nfatc2	RHD domain-containing protein. (896 aa)
	A0A1L8EUY4	Uncharacterized protein. (818 aa)
	fzd7	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (549 aa)
	A0A1L8F273	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (164 aa)
	A0A1L8F6T4	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	A0A1L8F6U2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (164 aa)
	wnt11b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	wnt4-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	axin2	Uncharacterized protein. (707 aa)
	dlx5	Homeobox domain-containing protein. (297 aa)
	eif3e	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (446 aa)
	Fzd6.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (715 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	Fzd8.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	fzd1	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa)
	Dlx5.L	Homeobox domain-containing protein. (298 aa)
	fzd6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (724 aa)
	EIF3E	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (409 aa)
	bmp2	TGF_BETA_2 domain-containing protein. (398 aa)
	Foxl2.S	Fork-head domain-containing protein. (328 aa)
	Bmp2.L	TGF_BETA_2 domain-containing protein. (398 aa)
	foxl2	Fork-head domain-containing protein. (328 aa)
	Lgr4.S	G_PROTEIN_RECEP_F1_2 domain-containing protein. (956 aa)
	Myod1.L	Myogenic factor. (289 aa)
	lgr4	G_PROTEIN_RECEP_F1_2 domain-containing protein. (953 aa)
	nfatc3	RHD domain-containing protein. (885 aa)
	A0A1L8GPB5	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (141 aa)
	cav3.1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (155 aa)
	Furin.S	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (783 aa)
	lgr5	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	myf5	Myogenic factor. (255 aa)
	Lgr5.L	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	cav2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (160 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	rnf43	RING-type domain-containing protein. (664 aa)
	Fzd4.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	msx1	Homeobox domain-containing protein. (275 aa)
	lef1	HMG box domain-containing protein. (372 aa)
	Kremen1.S	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (452 aa)
	kremen1	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (450 aa)
	MGC82408	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (160 aa)
	msx1-2	LOC100125666 protein. (273 aa)
	tnf-2	Tumor necrosis factor alpha. (225 aa)
	rspo2	R-spondin 2. (243 aa)
	nf-at	Nuclear factor of activated T-cell. (884 aa)
	xfz8	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	XMyf-5	Myogenic factor. (255 aa)
	vegfa	Vascular endothelial growth factor 196; Belongs to the PDGF/VEGF growth factor family. (194 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	myod1-a	Myoblast determination protein 1 homolog A; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (289 aa)
	edn1	LOC100158354 protein. (221 aa)
	pecam1-2	Platelet endothelial cell adhesion molecule. (727 aa)
	furin	LOC398345 protein; Belongs to the peptidase S8 family. (785 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	axin2-2	MGC81576 protein. (707 aa)
	cav1a	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
	rhoa	MGC64296 protein. (193 aa)
	cav3.2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	Cav-3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (141 aa)
	lef1-2	Lymphoid enhancer factor XLEF-1. (372 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ENI4	Bmp2.L	A0A1L8ENI4	A0A1L8G5P4	Uncharacterized protein.	TGF_BETA_2 domain-containing protein.	0.432
A0A1L8ENI4	Fzd4.S	A0A1L8ENI4	A0A1L8HB90	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.665
A0A1L8ENI4	Fzd6.S	A0A1L8ENI4	A0A1L8FTP5	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.566
A0A1L8ENI4	Fzd8.L	A0A1L8ENI4	A0A1L8FVD0	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.635
A0A1L8ENI4	Lgr4.S	A0A1L8ENI4	A0A1L8GDQ5	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.599
A0A1L8ENI4	Lgr5.L	A0A1L8ENI4	A0A1L8GYN0	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.817
A0A1L8ENI4	Tp53.L	A0A1L8ENI4	A0A1L8H4M6	Uncharacterized protein.	P53 domain-containing protein.	0.591
A0A1L8ENI4	bmp2	A0A1L8ENI4	A0A1L8G1N2	Uncharacterized protein.	TGF_BETA_2 domain-containing protein.	0.432
A0A1L8ENI4	ctnnb1	A0A1L8ENI4	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.998
A0A1L8ENI4	dkk1-2	A0A1L8ENI4	O57464	Uncharacterized protein.	Dickkopf homolog 1.	0.900
A0A1L8ENI4	fgf8	A0A1L8ENI4	Q8AXC5	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.471
A0A1L8ENI4	fzd1	A0A1L8ENI4	A0A1L8FVQ7	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.677
A0A1L8ENI4	fzd5	A0A1L8ENI4	A0A1L8EPX2	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.644
A0A1L8ENI4	fzd6	A0A1L8ENI4	A0A1L8FZR1	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.566
A0A1L8ENI4	fzd7	A0A1L8ENI4	A0A1L8EX17	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.652
A0A1L8ENI4	lef1	A0A1L8ENI4	A0A1L8HM07	Uncharacterized protein.	HMG box domain-containing protein.	0.922
A0A1L8ENI4	lef1-2	A0A1L8ENI4	Q90ZB8	Uncharacterized protein.	Lymphoid enhancer factor XLEF-1.	0.922
A0A1L8ENI4	lgr4	A0A1L8ENI4	A0A1L8GJ26	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.599
A0A1L8ENI4	lgr5	A0A1L8ENI4	A0A1L8GUF4	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.817
A0A1L8ENI4	msx1	A0A1L8ENI4	A0A1L8HKV3	Uncharacterized protein.	Homeobox domain-containing protein.	0.483