62 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cav1a	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	gdf5	TGF_BETA_2 domain-containing protein. (496 aa)
	Acvr1c.S	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (492 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	fzd7	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (549 aa)
	Notch1.S	Uncharacterized protein. (2524 aa)
	gpc4	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (549 aa)
	A0A1L8F3L0	Uncharacterized protein. (2377 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	notch1	Uncharacterized protein. (2521 aa)
	wnt11b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	prxl2a	Uncharacterized protein. (220 aa)
	Tgfbr1.S	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (454 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
	cript	Uncharacterized protein. (101 aa)
	A0A1L8G460	Phospholipase. (1039 aa)
	ptk2b	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1013 aa)
	tgfb2-2	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
	Pld1.L	Phospholipase. (1011 aa)
	ptk2b-2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1014 aa)
	Lgr4.S	G_PROTEIN_RECEP_F1_2 domain-containing protein. (956 aa)
	Cdh3.S	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (880 aa)
	Ptgs2.S	EGF-like domain-containing protein. (726 aa)
	lgr4	G_PROTEIN_RECEP_F1_2 domain-containing protein. (953 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	cdh1	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (871 aa)
	cdh3	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
	Smad3	Mothers against decapentaplegic homolog. (425 aa)
	Furin.S	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (783 aa)
	lgr5	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	wif1	Uncharacterized protein. (374 aa)
	Lgr5.L	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	pld2	Phospholipase. (939 aa)
	A0A1L8H5Q6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	rspo1	Uncharacterized protein. (257 aa)
	Wnt1.L	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	A0A1L8HJN4	Uncharacterized protein. (291 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	sfrp2	Uncharacterized protein. (295 aa)
	wif1-2	Wnt inhibitory factor-1. (374 aa)
	fgf9-A	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	cr1	Cripto-1. (190 aa)
	xfz8	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	XALK4	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	sfrpx	LOC100125663 protein. (288 aa)
	ccn2	Ctgf protein. (343 aa)
	gpc4-2	Xgly4 protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (556 aa)
	furin	LOC398345 protein; Belongs to the peptidase S8 family. (785 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	gdf5-2	Growth factor GDF5. (494 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
	sfrp2-2	Sfrp2-prov protein. (298 aa)
	Gapdh.S	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	hspa5-2	Hspa5 protein; Belongs to the heat shock protein 70 family. (655 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	smad3	Mothers against decapentaplegic homolog. (425 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8F3L0	Furin.S	A0A1L8F3L0	A0A1L8GSP1	Uncharacterized protein.	P/Homo B domain-containing protein; Belongs to the peptidase S8 family.	0.461
A0A1L8F3L0	Gapdh.S	A0A1L8F3L0	Q7ZY52	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.402
A0A1L8F3L0	ctnnb1	A0A1L8F3L0	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.592
A0A1L8F3L0	furin	A0A1L8F3L0	Q5XHG7	Uncharacterized protein.	LOC398345 protein; Belongs to the peptidase S8 family.	0.461
A0A1L8F3L0	gapdh	A0A1L8F3L0	Q8AY70	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.402
A0A1L8F3L0	myc	A0A1L8F3L0	Q6NRN4	Uncharacterized protein.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.494
A0A1L8G460	Pld1.L	A0A1L8G460	A0A1L8GA28	Phospholipase.	Phospholipase.	0.900
A0A1L8G460	cav1a	A0A1L8G460	Q6IRP8	Phospholipase.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.417
A0A1L8G460	pld2	A0A1L8G460	A0A1L8H3R4	Phospholipase.	Phospholipase.	0.902
A0A1L8H5Q6	Axin1.S	A0A1L8H5Q6	A0A1L8ER48	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.999
A0A1L8H5Q6	Cdh3.S	A0A1L8H5Q6	A0A1L8GET9	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.588
A0A1L8H5Q6	Gapdh.S	A0A1L8H5Q6	Q7ZY52	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Glyceraldehyde-3-phosphate dehydrogenase.	0.404
A0A1L8H5Q6	Lrp5.L	A0A1L8H5Q6	A0A1L8GJX4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.896
A0A1L8H5Q6	Notch1.S	A0A1L8H5Q6	A0A1L8F124	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.502
A0A1L8H5Q6	Wnt1.L	A0A1L8H5Q6	A0A1L8HHR8	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.795
A0A1L8H5Q6	cav1a	A0A1L8H5Q6	Q6IRP8	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.443
A0A1L8H5Q6	cdh1	A0A1L8H5Q6	A0A1L8GKV4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.577
A0A1L8H5Q6	cdh3	A0A1L8H5Q6	A0A1L8GKW6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.578
A0A1L8H5Q6	ctnnb1	A0A1L8H5Q6	Q63ZT4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Beta-catenin protein.	0.999
A0A1L8H5Q6	dkk1	A0A1L8H5Q6	A0A1L8FIS6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Dickkopf_N domain-containing protein.	0.606