26 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	shc1	Uncharacterized protein. (605 aa)
	sumo2	Small ubiquitin-related modifier. (95 aa)
	Sumo1.S	Ubiquitin-like domain-containing protein. (141 aa)
	sumo2-2	Ubiquitin-like domain-containing protein. (98 aa)
	Sumo1.L	Ubiquitin-like domain-containing protein. (148 aa)
	Shc1.L	Uncharacterized protein. (601 aa)
	ets1	Uncharacterized protein. (439 aa)
	Ets1.L	Uncharacterized protein. (439 aa)
	A0A1L8FND1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	tshb	Cys_knot domain-containing protein. (141 aa)
	Senp1.S	ULP_PROTEASE domain-containing protein. (546 aa)
	tshb-2	Cys_knot domain-containing protein. (141 aa)
	hdac1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
	Senp1.L	ULP_PROTEASE domain-containing protein. (616 aa)
	Ccna2.S	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (415 aa)
	areg	EGF-like domain-containing protein. (226 aa)
	areg-2	EGF-like domain-containing protein. (228 aa)
	ins-2	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	ccna2	MGC130969 protein; Belongs to the cyclin family. (415 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	Gapdh.S	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	hdac1-2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
	creb1	Creb1-prov protein. (324 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	ptch1-2	Patched-1. (1418 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FND1	Gapdh.S	A0A1L8FND1	Q7ZY52	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Glyceraldehyde-3-phosphate dehydrogenase.	0.701
A0A1L8FND1	Shc1.L	A0A1L8FND1	A0A1L8FDE2	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.633
A0A1L8FND1	creb1	A0A1L8FND1	Q8AVY5	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Creb1-prov protein.	0.586
A0A1L8FND1	gapdh	A0A1L8FND1	Q8AY70	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Glyceraldehyde-3-phosphate dehydrogenase.	0.701
A0A1L8FND1	ins	A0A1L8FND1	A0A1L8GD41	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.907
A0A1L8FND1	ins-2	A0A1L8FND1	B7ZQP1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.905
A0A1L8FND1	myc	A0A1L8FND1	Q6NRN4	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.646
A0A1L8FND1	shc1	A0A1L8FND1	A0A1L8F596	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.633
A0A1L8FND1	tshb	A0A1L8FND1	A0A1L8H6E4	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Cys_knot domain-containing protein.	0.424
A0A1L8FND1	tshb-2	A0A1L8FND1	A0A1L8HDY6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Cys_knot domain-containing protein.	0.424
Ccna2.S	Gapdh.S	A0A1L8HLX1	Q7ZY52	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.519
Ccna2.S	ccna2	A0A1L8HLX1	Q3KQ49	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	MGC130969 protein; Belongs to the cyclin family.	0.414
Ccna2.S	gapdh	A0A1L8HLX1	Q8AY70	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.519
Ccna2.S	hdac1	A0A1L8HLX1	A0A1L8HFI8	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.417
Ccna2.S	hdac1-2	A0A1L8HLX1	Q7ZYT5	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.417
Ccna2.S	ins	A0A1L8HLX1	A0A1L8GD41	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.405
Ccna2.S	ins-2	A0A1L8HLX1	B7ZQP1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.405
Ccna2.S	myc	A0A1L8HLX1	Q6NRN4	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.685
Ets1.L	ets1	A0A1L8FL38	A0A1L8FFQ1	Uncharacterized protein.	Uncharacterized protein.	0.923
Ets1.L	myc	A0A1L8FL38	Q6NRN4	Uncharacterized protein.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.441