45 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	uba2	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (641 aa)
	Desi1.L	DUF862 domain-containing protein. (169 aa)
	ep300-2	Uncharacterized protein. (2492 aa)
	Rad52.S	Uncharacterized protein. (429 aa)
	pias1	Uncharacterized protein. (640 aa)
	Hdac3.S	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (405 aa)
	Pias1.L	Uncharacterized protein. (649 aa)
	Dnmt1.L	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1488 aa)
	Senp3.L	ULP_PROTEASE domain-containing protein. (459 aa)
	Ranbp2.S	Uncharacterized protein. (2843 aa)
	uspl1	USP domain-containing protein. (1661 aa)
	hdac1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (830 aa)
	ranbp2	Uncharacterized protein. (2905 aa)
	Pias4.S	Uncharacterized protein. (543 aa)
	smc5	AAA_15 domain-containing protein. (1063 aa)
	Rnf4-a	RING-type domain-containing protein. (190 aa)
	ctcf	Uncharacterized protein. (746 aa)
	Pias4.L	Uncharacterized protein. (544 aa)
	desi1	DUF862 domain-containing protein. (169 aa)
	ep300	Uncharacterized protein. (2495 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	hdac1-2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
	ctcf-2	Ctcf protein. (735 aa)
	pias3	MGC81944 protein. (633 aa)
	rnf4	LOC495944 protein. (190 aa)
	cbx4-a	Chromobox homolog 4 (Polycomb). (521 aa)
	senp7	Sentrin/SUMO-specific protease 7. (901 aa)
	senp5-2	Sentrin/SUMO-specific protease 5. (722 aa)
	Ikzf1.S	C2H2-type domain-containing protein. (273 aa)
	sumo2	Small ubiquitin-related modifier. (95 aa)
	Sumo1.S	Ubiquitin-like domain-containing protein. (141 aa)
	crebbp	Uncharacterized protein. (2424 aa)
	cbx4	Uncharacterized protein. (438 aa)
	Brca1.L	Uncharacterized protein. (1582 aa)
	Sumo1.L	Ubiquitin-like domain-containing protein. (148 aa)
	crebbp-2	Uncharacterized protein. (2453 aa)
	mbd1	Uncharacterized protein. (638 aa)
	setdb1	Uncharacterized protein. (1290 aa)
	mbd1-2	Uncharacterized protein. (625 aa)
	Setdb1.L	Uncharacterized protein. (1343 aa)
	Stn1.S	Uncharacterized protein. (492 aa)
	ikzf1	Uncharacterized protein. (567 aa)
	Nsmce2.L	SP-RING-type domain-containing protein. (238 aa)
	senp5	ULP_PROTEASE domain-containing protein. (710 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Brca1.L	Dnmt1.L	A0A1L8ETS4	A0A1L8H2S5	Uncharacterized protein.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.574
Brca1.L	Pias1.L	A0A1L8ETS4	A0A1L8H180	Uncharacterized protein.	Uncharacterized protein.	0.698
Brca1.L	Pias4.L	A0A1L8ETS4	A0A1L8HW74	Uncharacterized protein.	Uncharacterized protein.	0.760
Brca1.L	Pias4.S	A0A1L8ETS4	A0A1L8HMW9	Uncharacterized protein.	Uncharacterized protein.	0.725
Brca1.L	Rad52.S	A0A1L8ETS4	A0A1L8GQQ7	Uncharacterized protein.	Uncharacterized protein.	0.984
Brca1.L	Rnf4-a	A0A1L8ETS4	A0A1L8HT51	Uncharacterized protein.	RING-type domain-containing protein.	0.534
Brca1.L	Stn1.S	A0A1L8ETS4	A0A1L8FEH3	Uncharacterized protein.	Uncharacterized protein.	0.563
Brca1.L	Sumo1.L	A0A1L8ETS4	A0A1L8EWZ5	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.712
Brca1.L	Sumo1.S	A0A1L8ETS4	A0A1L8EPQ0	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.712
Brca1.L	crebbp	A0A1L8ETS4	A0A1L8EQR2	Uncharacterized protein.	Uncharacterized protein.	0.889
Brca1.L	crebbp-2	A0A1L8ETS4	A0A1L8EYE5	Uncharacterized protein.	Uncharacterized protein.	0.889
Brca1.L	ep300	A0A1L8ETS4	A0A1L8GGW2	Uncharacterized protein.	Uncharacterized protein.	0.882
Brca1.L	ep300-2	A0A1L8ETS4	A0A1L8GNI9	Uncharacterized protein.	Uncharacterized protein.	0.882
Brca1.L	hdac1	A0A1L8ETS4	A0A1L8HFI8	Uncharacterized protein.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.576
Brca1.L	hdac1-2	A0A1L8ETS4	Q7ZYT5	Uncharacterized protein.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.576
Brca1.L	pcna	A0A1L8ETS4	Q9I893	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.528
Brca1.L	pias1	A0A1L8ETS4	A0A1L8GSB5	Uncharacterized protein.	Uncharacterized protein.	0.698
Brca1.L	pias3	A0A1L8ETS4	Q6GMA8	Uncharacterized protein.	MGC81944 protein.	0.632
Brca1.L	rnf4	A0A1L8ETS4	Q5PQ91	Uncharacterized protein.	LOC495944 protein.	0.534
Brca1.L	smc5	A0A1L8ETS4	A0A1L8HP39	Uncharacterized protein.	AAA_15 domain-containing protein.	0.815