node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A0A1L8EZY9 | psen1 | A0A1L8EZY9 | A0A1L8FAH5 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | 0.900 |
A0A1L8G0Y3 | AGO2 | A0A1L8G0Y3 | A0A1L8FTY9 | Xpo1 domain-containing protein. | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | 0.913 |
A0A1L8G0Y3 | AGO2-2 | A0A1L8G0Y3 | A0A1L8G073 | Xpo1 domain-containing protein. | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | 0.913 |
A0A1L8G0Y3 | Dicer1.S | A0A1L8G0Y3 | A0A1L8F0C9 | Xpo1 domain-containing protein. | Uncharacterized protein; Belongs to the helicase family. Dicer subfamily. | 0.976 |
A0A1L8G0Y3 | ago1 | A0A1L8G0Y3 | A0A1L8H7N2 | Xpo1 domain-containing protein. | Uncharacterized protein; Belongs to the argonaute family. | 0.775 |
A0A1L8G0Y3 | ago1-2 | A0A1L8G0Y3 | A0A1L8HFA4 | Xpo1 domain-containing protein. | Uncharacterized protein; Belongs to the argonaute family. | 0.776 |
A0A1L8G0Y3 | dicer1 | A0A1L8G0Y3 | A0A1L8F9L1 | Xpo1 domain-containing protein. | Uncharacterized protein; Belongs to the helicase family. Dicer subfamily. | 0.976 |
A0A1L8G0Y3 | lin28b | A0A1L8G0Y3 | A0A1L8G2U8 | Xpo1 domain-containing protein. | CCHC-type domain-containing protein. | 0.516 |
A0A1L8G0Y3 | xpo5 | A0A1L8G0Y3 | A0A1L8G0T7 | Xpo1 domain-containing protein. | Importin N-terminal domain-containing protein. | 0.903 |
AGO2 | A0A1L8G0Y3 | A0A1L8FTY9 | A0A1L8G0Y3 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Xpo1 domain-containing protein. | 0.913 |
AGO2 | Dicer1.S | A0A1L8FTY9 | A0A1L8F0C9 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Uncharacterized protein; Belongs to the helicase family. Dicer subfamily. | 0.999 |
AGO2 | ago1 | A0A1L8FTY9 | A0A1L8H7N2 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Uncharacterized protein; Belongs to the argonaute family. | 0.827 |
AGO2 | ago1-2 | A0A1L8FTY9 | A0A1L8HFA4 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Uncharacterized protein; Belongs to the argonaute family. | 0.827 |
AGO2 | dicer1 | A0A1L8FTY9 | A0A1L8F9L1 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Uncharacterized protein; Belongs to the helicase family. Dicer subfamily. | 0.999 |
AGO2 | lin28a | A0A1L8FTY9 | B7ZPW6 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | RNA-binding protein LIN-28A. | 0.552 |
AGO2 | lin28b | A0A1L8FTY9 | A0A1L8G2U8 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | CCHC-type domain-containing protein. | 0.593 |
AGO2 | ptbp1 | A0A1L8FTY9 | Q7ZXB4 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Ptbp1 protein. | 0.672 |
AGO2 | xpo5 | A0A1L8FTY9 | A0A1L8G0T7 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Importin N-terminal domain-containing protein. | 0.918 |
AGO2-2 | A0A1L8G0Y3 | A0A1L8G073 | A0A1L8G0Y3 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Xpo1 domain-containing protein. | 0.913 |
AGO2-2 | Dicer1.S | A0A1L8G073 | A0A1L8F0C9 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Uncharacterized protein; Belongs to the helicase family. Dicer subfamily. | 0.999 |