19 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	sumo2	Small ubiquitin-related modifier. (95 aa)
	Sumo1.S	Ubiquitin-like domain-containing protein. (141 aa)
	Sumo1.L	Ubiquitin-like domain-containing protein. (148 aa)
	cdk1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
	Cdk1.L	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (333 aa)
	A0A1L8FND1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
	banf1	Uncharacterized protein. (90 aa)
	rce1	Uncharacterized protein. (310 aa)
	banf1-2	Uncharacterized protein. (90 aa)
	Lemd3.S	LEM domain-containing protein. (782 aa)
	Hdac3.S	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (405 aa)
	lemd3	LEM domain-containing protein. (783 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (466 aa)
	emd	Xemd1 protein. (180 aa)
	ins-2	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
	prkca	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (677 aa)
	lmnb1	Lmnb1-prov protein; Belongs to the intermediate filament family. (584 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FND1	ins	A0A1L8FND1	A0A1L8GD41	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.907
A0A1L8FND1	ins-2	A0A1L8FND1	B7ZQP1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.905
Cdk1.L	cdk1	A0A1L8FIT4	A0A1L8FE96	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.900
Cdk1.L	ins	A0A1L8FIT4	A0A1L8GD41	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.417
Cdk1.L	ins-2	A0A1L8FIT4	B7ZQP1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.416
Cdk1.L	lmnb1	A0A1L8FIT4	Q8AVZ3	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Lmnb1-prov protein; Belongs to the intermediate filament family.	0.650
Cdk1.L	parp1	A0A1L8FIT4	Q2NLA7	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.419
Cdk1.L	sumo2	A0A1L8FIT4	A0A1L8EMU2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Small ubiquitin-related modifier.	0.477
Hdac3.S	Lemd3.S	A0A1L8GVJ7	A0A1L8GUJ5	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	LEM domain-containing protein.	0.438
Hdac3.S	Sumo1.L	A0A1L8GVJ7	A0A1L8EWZ5	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Ubiquitin-like domain-containing protein.	0.440
Hdac3.S	Sumo1.S	A0A1L8GVJ7	A0A1L8EPQ0	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Ubiquitin-like domain-containing protein.	0.440
Hdac3.S	banf1	A0A1L8GVJ7	A0A1L8GCL6	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Uncharacterized protein.	0.461
Hdac3.S	banf1-2	A0A1L8GVJ7	A0A1L8GK00	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Uncharacterized protein.	0.461
Hdac3.S	emd	A0A1L8GVJ7	B7ZPV1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Xemd1 protein.	0.879
Hdac3.S	lemd3	A0A1L8GVJ7	A0A1L8GYG3	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	LEM domain-containing protein.	0.438
Hdac3.S	sumo2	A0A1L8GVJ7	A0A1L8EMU2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Small ubiquitin-related modifier.	0.544
Lemd3.S	Hdac3.S	A0A1L8GUJ5	A0A1L8GVJ7	LEM domain-containing protein.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.438
Lemd3.S	banf1	A0A1L8GUJ5	A0A1L8GCL6	LEM domain-containing protein.	Uncharacterized protein.	0.992
Lemd3.S	banf1-2	A0A1L8GUJ5	A0A1L8GK00	LEM domain-containing protein.	Uncharacterized protein.	0.990
Lemd3.S	emd	A0A1L8GUJ5	B7ZPV1	LEM domain-containing protein.	Xemd1 protein.	0.991