STRINGSTRING
hdac4 hdac4 A0A1L8EM88 A0A1L8EM88 h3f3b h3f3b trrap trrap rnf40 rnf40 Brca1.L Brca1.L A0A1L8EY07 A0A1L8EY07 rnf40-2 rnf40-2 Exo1.S Exo1.S mdc1 mdc1 Tdp1.L Tdp1.L Dna2.S Dna2.S chek1 chek1 trim28 trim28 pnkp pnkp chek1-2 chek1-2 Cdc25a.S Cdc25a.S rbbp8 rbbp8 Myc.S Myc.S topbp1 topbp1 Rbbp8.L Rbbp8.L Prkdc.L Prkdc.L Nbn.L Nbn.L hist2h3c hist2h3c H2B-2 H2B-2 rnf8 rnf8 rnf168 rnf168 RNF8 RNF8 Bub1.L Bub1.L rnf168-2 rnf168-2 Cep63.L Cep63.L rag2 rag2 rag1 rag1 atrip atrip rag1-2 rag1-2 Kat5.L Kat5.L Rad26 Rad26 Cdc25c1 Cdc25c1 rad50 rad50 rad50-2 rad50-2 mdm2 mdm2 Lmnb3.L Lmnb3.L Hspb1.S Hspb1.S Cdk2.S Cdk2.S zmpste24 zmpste24 Hspb1.L Hspb1.L Smarca5.S Smarca5.S Lmnb2.S Lmnb2.S Lmnb1.S Lmnb1.S Chek2.L Chek2.L A0A310TTQ1 A0A310TTQ1 Hist2h2ab.S Hist2h2ab.S rnf20 rnf20 Clspn.S Clspn.S LOC397912 LOC397912 lig4 lig4 cradd.2 cradd.2 myc myc rad9a rad9a creb1 creb1 lmnb1 lmnb1 Hus1 Hus1 H2B H2B lbr lbr
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
A0A1L8EM88Uncharacterized protein. (445 aa)
h3f3bHistone H3; Belongs to the histone H3 family. (136 aa)
trrapUncharacterized protein; Belongs to the PI3/PI4-kinase family. (3838 aa)
rnf40E3 ubiquitin protein ligase. (992 aa)
Brca1.LUncharacterized protein. (1582 aa)
A0A1L8EY07Histone H3; Belongs to the histone H3 family. (120 aa)
rnf40-2E3 ubiquitin protein ligase. (991 aa)
Exo1.SUncharacterized protein. (734 aa)
mdc1Uncharacterized protein. (2103 aa)
Tdp1.LUncharacterized protein. (597 aa)
Dna2.SUncharacterized protein. (1053 aa)
chek1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
trim28Uncharacterized protein. (798 aa)
pnkpFHA_2 domain-containing protein. (594 aa)
chek1-2Protein kinase domain-containing protein. (510 aa)
Cdc25a.SRhodanese domain-containing protein. (172 aa)
rbbp8Uncharacterized protein. (846 aa)
Myc.SMyc_N domain-containing protein. (176 aa)
topbp1Uncharacterized protein. (1573 aa)
Rbbp8.LUncharacterized protein. (856 aa)
Prkdc.LUncharacterized protein; Belongs to the PI3/PI4-kinase family. (4146 aa)
Nbn.LNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (762 aa)
hist2h3cHistone H3; Belongs to the histone H3 family. (136 aa)
H2B-2Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (233 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (540 aa)
rnf168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (554 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (532 aa)
Bub1.LUncharacterized protein. (1135 aa)
rnf168-2E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (565 aa)
Cep63.LCEP63 domain-containing protein. (524 aa)
rag2RAG2_PHD domain-containing protein. (520 aa)
rag1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1045 aa)
atripUncharacterized protein. (801 aa)
rag1-2V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1045 aa)
Kat5.LHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (508 aa)
Rad26Uncharacterized protein. (798 aa)
Cdc25c1Rhodanese domain-containing protein. (550 aa)
rad50Zinc-hook domain-containing protein. (1311 aa)
rad50-2Zinc-hook domain-containing protein. (1312 aa)
mdm2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (489 aa)
Lmnb3.LUncharacterized protein; Belongs to the intermediate filament family. (583 aa)
Hspb1.SSHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (263 aa)
Cdk2.SProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
zmpste24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (466 aa)
Hspb1.LSHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (272 aa)
Smarca5.SUncharacterized protein. (1046 aa)
Lmnb2.SUncharacterized protein; Belongs to the intermediate filament family. (666 aa)
Lmnb1.SUncharacterized protein; Belongs to the intermediate filament family. (583 aa)
Chek2.LUncharacterized protein. (392 aa)
A0A310TTQ1Histone H3; Belongs to the histone H3 family. (136 aa)
Hist2h2ab.SHistone H2A; Belongs to the histone H2A family. (139 aa)
rnf20E3 ubiquitin protein ligase. (965 aa)
Clspn.SClaspin. (1286 aa)
LOC397912LOC397912 protein; Belongs to the intermediate filament family. (623 aa)
lig4DNA ligase. (911 aa)
cradd.2MGC78788 protein. (197 aa)
mycTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
creb1Creb1-prov protein. (324 aa)
lmnb1Lmnb1-prov protein; Belongs to the intermediate filament family. (584 aa)
Hus1Checkpoint protein; Belongs to the HUS1 family. (282 aa)
H2BHistone H2B; Belongs to the histone H2B family. (126 aa)
lbrLamin B receptor. (620 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
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