64 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Sox2.S	HMG box domain-containing protein. (194 aa)
	gbx2.2	Homeobox domain-containing protein. (340 aa)
	Frzb.S	Uncharacterized protein. (319 aa)
	Frzb-1	Uncharacterized protein. (319 aa)
	Gbx2.2.L	Homeobox domain-containing protein. (340 aa)
	Notch1.S	Uncharacterized protein. (2524 aa)
	notch1	Uncharacterized protein. (2521 aa)
	wnt11b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	Pax-2	Paired domain-containing protein. (495 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	ascl2	BHLH domain-containing protein. (161 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	pax2	Paired domain-containing protein. (497 aa)
	wnt4-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	dlx5	Homeobox domain-containing protein. (297 aa)
	Rho.L	Rhodopsin. (459 aa)
	Fzd6.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (715 aa)
	Wnt9a.S	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (528 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	Fzd8.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	fzd1	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa)
	Dlx5.L	Homeobox domain-containing protein. (298 aa)
	vxn	Vexin; Required for neurogenesis in the neural plate and retina. Cooperates with cell cycle inhibitor cdknx/p27(xic1) to enhance neurogenesis and increase the levels of the neuronal determination factor neurog2/X-ngngr-1. (190 aa)
	fzd6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (724 aa)
	jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1206 aa)
	H2B-2	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (233 aa)
	prox1	Prospero domain-containing protein. (739 aa)
	myo6	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1297 aa)
	prox1-2	Prospero domain-containing protein. (740 aa)
	fgf20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	pou4f1.2	POU domain protein. (343 aa)
	H2B	Histone H2B; Belongs to the histone H2B family. (126 aa)
	ascl2-2	Achaete-scute homolog 3b. (191 aa)
	gbx2.1-2	Homeobox protein GBX-2b. (336 aa)
	ror2-2	Receptor tyrosine kinase Xror2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
	actl6a	Baf53a-pending-prov protein; Belongs to the actin family. (429 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	rac1	MGC114731 protein. (192 aa)
	cdh11-2	Cadherin; Cadherins are calcium-dependent cell adhesion proteins. (794 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	atoh7	Atonal homolog 5a. (138 aa)
	xfz8	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	fzd10a	Frizzled 10A; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
	wif1-2	Wnt inhibitory factor-1. (374 aa)
	gbx2.1	Homeobox domain-containing protein. (340 aa)
	Elavl3.L	ELAV-like protein; Belongs to the RRM elav family. (341 aa)
	rbpj	Uncharacterized protein. (487 aa)
	fzd10	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
	ror2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
	atoh1-2	BHLH domain-containing protein. (256 aa)
	Rbpj.S	Uncharacterized protein. (485 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	rspo1	Uncharacterized protein. (257 aa)
	Fzd4.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
	Sfrp1.L	Uncharacterized protein. (311 aa)
	Lgr5.L	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	wif1	Uncharacterized protein. (374 aa)
	lgr5	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	sfrp1	Uncharacterized protein. (311 aa)
	Cdkn1b.S	Uncharacterized protein. (152 aa)
	Jag1.L	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1214 aa)
	ryk	Uncharacterized protein. (596 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	atoh1	Atonal 1. (263 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cdkn1b.S	Jag1.L	A0A1L8GQW1	A0A1L8G723	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.409
Cdkn1b.S	Notch1.S	A0A1L8GQW1	A0A1L8F124	Uncharacterized protein.	Uncharacterized protein.	0.483
Cdkn1b.S	Sox2.S	A0A1L8GQW1	A0A1L8EK54	Uncharacterized protein.	HMG box domain-containing protein.	0.434
Cdkn1b.S	actl6a	A0A1L8GQW1	Q7ZYI5	Uncharacterized protein.	Baf53a-pending-prov protein; Belongs to the actin family.	0.436
Cdkn1b.S	atoh1	A0A1L8GQW1	A0A0U2URD9	Uncharacterized protein.	Atonal 1.	0.492
Cdkn1b.S	atoh1-2	A0A1L8GQW1	A0A1L8HMA4	Uncharacterized protein.	BHLH domain-containing protein.	0.493
Cdkn1b.S	jag1	A0A1L8GQW1	A0A1L8G0P5	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.409
Cdkn1b.S	notch1	A0A1L8GQW1	A0A1L8F627	Uncharacterized protein.	Uncharacterized protein.	0.484
Dlx5.L	Pax-2	A0A1L8FVV2	A0A1L8FF43	Homeobox domain-containing protein.	Paired domain-containing protein.	0.565
Dlx5.L	Sox2.S	A0A1L8FVV2	A0A1L8EK54	Homeobox domain-containing protein.	HMG box domain-containing protein.	0.522
Dlx5.L	ctnnb1	A0A1L8FVV2	Q63ZT4	Homeobox domain-containing protein.	Beta-catenin protein.	0.468
Dlx5.L	pax2	A0A1L8FVV2	A0A1L8FJY5	Homeobox domain-containing protein.	Paired domain-containing protein.	0.564
Dlx5.L	wnt3a	A0A1L8FVV2	A0A1L8FUX8	Homeobox domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.432
Elavl3.L	Sox2.S	A0A310U5A2	A0A1L8EK54	ELAV-like protein; Belongs to the RRM elav family.	HMG box domain-containing protein.	0.487
Elavl3.L	atoh7	A0A310U5A2	B7ZQX7	ELAV-like protein; Belongs to the RRM elav family.	Atonal homolog 5a.	0.515
Elavl3.L	vxn	A0A310U5A2	A0A1L8FZ84	ELAV-like protein; Belongs to the RRM elav family.	Vexin; Required for neurogenesis in the neural plate and retina. Cooperates with cell cycle inhibitor cdknx/p27(xic1) to enhance neurogenesis and increase the levels of the neuronal determination factor neurog2/X-ngngr-1.	0.552
Frzb-1	Lrp5.L	A0A1L8EWF4	A0A1L8GJX4	Uncharacterized protein.	Uncharacterized protein.	0.612
Frzb-1	Sfrp1.L	A0A1L8EWF4	A0A1L8H1S5	Uncharacterized protein.	Uncharacterized protein.	0.410
Frzb-1	Wnt9a.S	A0A1L8EWF4	A0A1L8FUX2	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.650
Frzb-1	ctnnb1	A0A1L8EWF4	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.777