15 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	chek1-2	Protein kinase domain-containing protein. (510 aa)
	topbp1	Uncharacterized protein. (1573 aa)
	Nbn.L	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (762 aa)
	atrip	Uncharacterized protein. (801 aa)
	rad50	Zinc-hook domain-containing protein. (1311 aa)
	rad50-2	Zinc-hook domain-containing protein. (1312 aa)
	rpa2	RPA_C domain-containing protein. (274 aa)
	rpa2-2	RPA_C domain-containing protein. (276 aa)
	Rad17.L	Uncharacterized protein. (674 aa)
	Rfc2.L	AAA domain-containing protein. (359 aa)
	rad1	Uncharacterized protein. (283 aa)
	Hus1	Checkpoint protein; Belongs to the HUS1 family. (282 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
	rfc4	Replication factor C p37 subunit. (363 aa)
	mdc1	Uncharacterized protein. (2103 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Hus1	Nbn.L	Q8JHD8	A0A1L8FZE8	Checkpoint protein; Belongs to the HUS1 family.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.950
Hus1	Rad17.L	Q8JHD8	A0A1L8I1Y0	Checkpoint protein; Belongs to the HUS1 family.	Uncharacterized protein.	0.999
Hus1	Rfc2.L	Q8JHD8	A0A1L8HGA4	Checkpoint protein; Belongs to the HUS1 family.	AAA domain-containing protein.	0.999
Hus1	atrip	Q8JHD8	A0A1L8GH95	Checkpoint protein; Belongs to the HUS1 family.	Uncharacterized protein.	0.981
Hus1	chek1-2	Q8JHD8	A0A1L8FL95	Checkpoint protein; Belongs to the HUS1 family.	Protein kinase domain-containing protein.	0.985
Hus1	mdc1	Q8JHD8	A0A1L8F8K7	Checkpoint protein; Belongs to the HUS1 family.	Uncharacterized protein.	0.747
Hus1	rad1	Q8JHD8	A0A1L8I2M6	Checkpoint protein; Belongs to the HUS1 family.	Uncharacterized protein.	0.999
Hus1	rad50	Q8JHD8	A0A1L8GVF0	Checkpoint protein; Belongs to the HUS1 family.	Zinc-hook domain-containing protein.	0.677
Hus1	rad50-2	Q8JHD8	A0A1L8GXM0	Checkpoint protein; Belongs to the HUS1 family.	Zinc-hook domain-containing protein.	0.674
Hus1	rad9a	Q8JHD8	Q7ZZU5	Checkpoint protein; Belongs to the HUS1 family.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.999
Hus1	rfc4	Q8JHD8	Q76LD2	Checkpoint protein; Belongs to the HUS1 family.	Replication factor C p37 subunit.	0.999
Hus1	rpa2	Q8JHD8	A0A1L8H7J6	Checkpoint protein; Belongs to the HUS1 family.	RPA_C domain-containing protein.	0.790
Hus1	rpa2-2	Q8JHD8	A0A1L8HE73	Checkpoint protein; Belongs to the HUS1 family.	RPA_C domain-containing protein.	0.790
Hus1	topbp1	Q8JHD8	A0A1L8FWJ6	Checkpoint protein; Belongs to the HUS1 family.	Uncharacterized protein.	0.998
Nbn.L	Hus1	A0A1L8FZE8	Q8JHD8	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	Checkpoint protein; Belongs to the HUS1 family.	0.950
Nbn.L	Rad17.L	A0A1L8FZE8	A0A1L8I1Y0	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	Uncharacterized protein.	0.935
Nbn.L	Rfc2.L	A0A1L8FZE8	A0A1L8HGA4	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	AAA domain-containing protein.	0.868
Nbn.L	atrip	A0A1L8FZE8	A0A1L8GH95	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	Uncharacterized protein.	0.902
Nbn.L	chek1-2	A0A1L8FZE8	A0A1L8FL95	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	Protein kinase domain-containing protein.	0.912
Nbn.L	mdc1	A0A1L8FZE8	A0A1L8F8K7	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	Uncharacterized protein.	0.986