(45 nodes) (2014) Physiology and pathophysiology of SLC12A12 transporters. network (Xenopus laevis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	cftr-2	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1485 aa)
	wnk4	Protein kinase domain-containing protein. (1573 aa)
	wnk4-2	Protein kinase domain-containing protein. (1575 aa)
	foxa1	Fork-head domain-containing protein. (427 aa)
	foxa1-2	Fork-head domain-containing protein. (429 aa)
	kcnj1	Uncharacterized protein. (371 aa)
	Clcnkb.L	Chloride channel protein. (688 aa)
	A0A1L8G4K9	Uncharacterized protein. (341 aa)
	osr1	Uncharacterized protein. (259 aa)
	osr1-2	Uncharacterized protein. (259 aa)
	A0A1L8GE13	CALCITONIN domain-containing protein. (138 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (396 aa)
	A0A1L8GGH3	Alpha-amylase. (526 aa)
	A0A1L8GGI2	Alpha-amylase. (409 aa)
	A0A1L8GGJ8	Alpha-amylase. (462 aa)
	A0A1L8GIE1	CALCITONIN domain-containing protein. (138 aa)
	kcnq1	Uncharacterized protein; Belongs to the potassium channel family. (652 aa)
	Prkacb.S	Uncharacterized protein; Belongs to the protein kinase superfamily. (338 aa)
	Amy2a.L	Alpha-amylase. (511 aa)
	scamp2	Secretory carrier-associated membrane protein. (331 aa)
	Tm7	Uncharacterized protein; Belongs to the tropomyosin family. (284 aa)
	cftr	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1483 aa)
	Tpm1.L	Uncharacterized protein; Belongs to the tropomyosin family. (326 aa)
	slc12a1	Uncharacterized protein. (1086 aa)
	Il1b.L	Interleukin-1. (145 aa)
	Ren.S	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (366 aa)
	stk24	Protein kinase domain-containing protein. (425 aa)
	A0A1L8HAA3	Uncharacterized protein. (337 aa)
	slc12a2	Uncharacterized protein. (1142 aa)
	slc12a2-2	Uncharacterized protein. (1158 aa)
	oxsr1	Stk39 protein. (528 aa)
	LOC100189571	Uncharacterized protein. (608 aa)
	il1b-A	Interleukin-1; Belongs to the IL-1 family. (283 aa)
	prkaa1	Non-specific serine/threonine protein kinase. (560 aa)
	scamp2-2	Secretory carrier-associated membrane protein. (327 aa)
	kcnj1-2	MGC86330 protein. (372 aa)
	stk24-2	MGC80614 protein. (424 aa)
	cab39	MGC78903 protein. (341 aa)
	cab39l	MGC68674 protein. (337 aa)
	mal	MGC68692 protein. (159 aa)
	hif1a	Hif1a-prov protein. (802 aa)
	kcne1	Voltage-gated potassium channel subunit MinK. (118 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (560 aa)
	prkaca	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	XALDB1	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8G4K9	osr1	A0A1L8G4K9	A0A1L8G5J9	Uncharacterized protein.	Uncharacterized protein.	0.558
A0A1L8G4K9	osr1-2	A0A1L8G4K9	A0A1L8GBX6	Uncharacterized protein.	Uncharacterized protein.	0.558
A0A1L8G4K9	oxsr1	A0A1L8G4K9	A0JPG0	Uncharacterized protein.	Stk39 protein.	0.769
A0A1L8G4K9	prkaa1	A0A1L8G4K9	Q5U5E3	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.830
A0A1L8G4K9	prkaa2	A0A1L8G4K9	Q8UVW8	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.830
A0A1L8G4K9	slc12a2	A0A1L8G4K9	A0A1L8HQZ9	Uncharacterized protein.	Uncharacterized protein.	0.559
A0A1L8G4K9	slc12a2-2	A0A1L8G4K9	A0A1L8I1I1	Uncharacterized protein.	Uncharacterized protein.	0.559
A0A1L8G4K9	stk24	A0A1L8G4K9	A0A1L8H969	Uncharacterized protein.	Protein kinase domain-containing protein.	0.858
A0A1L8G4K9	stk24-2	A0A1L8G4K9	Q6GP83	Uncharacterized protein.	MGC80614 protein.	0.858
A0A1L8G4K9	wnk4	A0A1L8G4K9	A0A1L8EMC7	Uncharacterized protein.	Protein kinase domain-containing protein.	0.541
A0A1L8G4K9	wnk4-2	A0A1L8G4K9	A0A1L8ETQ6	Uncharacterized protein.	Protein kinase domain-containing protein.	0.541
A0A1L8GE13	A0A1L8GIE1	A0A1L8GE13	A0A1L8GIE1	CALCITONIN domain-containing protein.	CALCITONIN domain-containing protein.	0.900
A0A1L8GGH3	Amy2a.L	A0A1L8GGH3	A0A1L8GN50	Alpha-amylase.	Alpha-amylase.	0.901
A0A1L8GGH3	slc12a2	A0A1L8GGH3	A0A1L8HQZ9	Alpha-amylase.	Uncharacterized protein.	0.485
A0A1L8GGH3	slc12a2-2	A0A1L8GGH3	A0A1L8I1I1	Alpha-amylase.	Uncharacterized protein.	0.485
A0A1L8GGI2	slc12a2	A0A1L8GGI2	A0A1L8HQZ9	Alpha-amylase.	Uncharacterized protein.	0.485
A0A1L8GGI2	slc12a2-2	A0A1L8GGI2	A0A1L8I1I1	Alpha-amylase.	Uncharacterized protein.	0.485
A0A1L8GGJ8	slc12a2	A0A1L8GGJ8	A0A1L8HQZ9	Alpha-amylase.	Uncharacterized protein.	0.485
A0A1L8GGJ8	slc12a2-2	A0A1L8GGJ8	A0A1L8I1I1	Alpha-amylase.	Uncharacterized protein.	0.485
A0A1L8GIE1	A0A1L8GE13	A0A1L8GIE1	A0A1L8GE13	CALCITONIN domain-containing protein.	CALCITONIN domain-containing protein.	0.900