95 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Wnt5b.S	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (375 aa)
	wnt10a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	crebbp	Uncharacterized protein. (2424 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	Prmt2.L	SH3 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (644 aa)
	crebbp-2	Uncharacterized protein. (2453 aa)
	Dact1.S	Uncharacterized protein. (818 aa)
	Notch1.S	Uncharacterized protein. (2524 aa)
	notch1	Uncharacterized protein. (2521 aa)
	wnt11b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	dact1	Uncharacterized protein. (824 aa)
	tnks2	Poly [ADP-ribose] polymerase. (1165 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	wnt4-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	Bmi1.S	RING-type domain-containing protein. (367 aa)
	Myc.S	Myc_N domain-containing protein. (176 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	Shh.L	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (444 aa)
	Bmi1.L	RING-type domain-containing protein. (323 aa)
	fzd1	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa)
	sostdc1	CTCK domain-containing protein. (213 aa)
	Esr1.S	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	pik3cb	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	pik3cb-2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	ryk	Uncharacterized protein. (596 aa)
	lrp4	Uncharacterized protein. (1906 aa)
	Cdh3.S	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (880 aa)
	wls	Uncharacterized protein. (541 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (396 aa)
	ep300	Uncharacterized protein. (2495 aa)
	lrp4-2	Uncharacterized protein. (1908 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	cdh1	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (871 aa)
	cdh3	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
	Prkacb.S	Uncharacterized protein; Belongs to the protein kinase superfamily. (338 aa)
	Wls.L	Uncharacterized protein. (541 aa)
	ep300-2	Uncharacterized protein. (2492 aa)
	ruvbl1	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
	nkx3-1	Homeobox domain-containing protein. (213 aa)
	pik3cg	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1115 aa)
	lgr5	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	ctbp2l	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (480 aa)
	wif1	Uncharacterized protein. (374 aa)
	Lgr5.L	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	mesd	Uncharacterized protein. (214 aa)
	Nkx3-1.L	Homeobox domain-containing protein. (213 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	A0A1L8H5D7	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (478 aa)
	A0A1L8H5H0	Uncharacterized protein; Belongs to the peptidase S1 family. (547 aa)
	tmprss24	Uncharacterized protein; Belongs to the peptidase S1 family. (500 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	PR-2	Uncharacterized protein. (730 aa)
	Fzd4.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
	A0A1L8HC97	Uncharacterized protein; Belongs to the peptidase S1 family. (437 aa)
	tmprss2	Uncharacterized protein; Belongs to the peptidase S1 family. (476 aa)
	A0A1L8HCA8	Peptidase S1 domain-containing protein. (98 aa)
	Xesp-2	Peptidase S1 domain-containing protein. (108 aa)
	A0A1L8HCB9	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (474 aa)
	A0A1L8HCC1	Uncharacterized protein; Belongs to the peptidase S1 family. (492 aa)
	A0A1L8HCD7	Uncharacterized protein; Belongs to the peptidase S1 family. (499 aa)
	cdkn1a	Uncharacterized protein. (261 aa)
	Wnt1.L	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	wnt10b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
	A0A1L8HJF4	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (456 aa)
	A0A1L8HJN4	Uncharacterized protein. (291 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	lef1	HMG box domain-containing protein. (372 aa)
	tnks	Poly [ADP-ribose] polymerase. (1298 aa)
	ror2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
	msi1	Uncharacterized protein. (340 aa)
	ctbp1	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (441 aa)
	sfrp2	Uncharacterized protein. (295 aa)
	wnt6-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	wif1-2	Wnt inhibitory factor-1. (374 aa)
	wnt10a-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	itgb3	Integrin beta; Belongs to the integrin beta chain family. (788 aa)
	wnt7b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	sfrpx	LOC100125663 protein. (288 aa)
	rac1	MGC114731 protein. (192 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	prkca	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (677 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	sostdc1-2	Wise-A. (213 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	rhoa	MGC64296 protein. (193 aa)
	sfrp2-2	Sfrp2-prov protein. (298 aa)
	ror2-2	Receptor tyrosine kinase Xror2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
	ccnd1	Ccnd1-prov protein; Belongs to the cyclin family. (291 aa)
	prkaca	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	lef1-2	Lymphoid enhancer factor XLEF-1. (372 aa)
	pgr	Progesterone receptor. (732 aa)
	rac3	RAC1 protein. (192 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8HJF4	A0A1L8HJN4	A0A1L8HJF4	A0A1L8HJN4	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.650
A0A1L8HJF4	Axin1.S	A0A1L8HJF4	A0A1L8ER48	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.439
A0A1L8HJF4	Lrp5.L	A0A1L8HJF4	A0A1L8GJX4	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.982
A0A1L8HJF4	Wnt1.L	A0A1L8HJF4	A0A1L8HHR8	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.863
A0A1L8HJF4	Wnt5b.S	A0A1L8HJF4	A0A1L8GQS0	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.961
A0A1L8HJF4	ctnnb1	A0A1L8HJF4	Q63ZT4	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Beta-catenin protein.	0.664
A0A1L8HJF4	lrp4	A0A1L8HJF4	A0A1L8GDI9	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.515
A0A1L8HJF4	lrp4-2	A0A1L8HJF4	A0A1L8GIP6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.515
A0A1L8HJF4	ror2	A0A1L8HJF4	A0A1L8HPI6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.823
A0A1L8HJF4	ror2-2	A0A1L8HJF4	Q8AV69	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase Xror2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.823
A0A1L8HJF4	ryk	A0A1L8HJF4	A0A1L8GB75	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.741
A0A1L8HJF4	sfrp2	A0A1L8HJF4	A0A1L8HUI3	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.674
A0A1L8HJF4	sfrp2-2	A0A1L8HJF4	Q7ZXM6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Sfrp2-prov protein.	0.674
A0A1L8HJF4	sfrpx	A0A1L8HJF4	Q0IHH5	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	LOC100125663 protein.	0.650
A0A1L8HJF4	wnt1	A0A1L8HJF4	A0A1L8H9S8	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.863
A0A1L8HJF4	wnt10a	A0A1L8HJF4	A0A1L8ENU7	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.788
A0A1L8HJF4	wnt10a-2	A0A1L8HJF4	B7ZQU5	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.788
A0A1L8HJF4	wnt10b	A0A1L8HJF4	A0A1L8HHS0	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.789
A0A1L8HJF4	wnt11	A0A1L8HJF4	A0A1L8HJX1	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.911
A0A1L8HJF4	wnt11b	A0A1L8HJF4	A0A1L8F6W4	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.910