61 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	stk11	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (432 aa)
	arvcf	Uncharacterized protein. (919 aa)
	fzd10	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
	Kremen1.S	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (452 aa)
	ccdc68	Uncharacterized protein. (346 aa)
	stk11-2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (432 aa)
	csnk1g2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (412 aa)
	A0A1L8HXA8	Uncharacterized protein. (896 aa)
	vldlr	Uncharacterized protein. (894 aa)
	arvcf-2	Uncharacterized protein. (919 aa)
	kremen1	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (450 aa)
	ccdc68-2	Uncharacterized protein. (346 aa)
	XE2.1	BHLH domain-containing protein. (502 aa)
	en2-2	Homeobox protein engrailed-like. (265 aa)
	Xwnt-8b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (428 aa)
	fzd10a	Frizzled 10A; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
	xfz8	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	actl6a	Baf53a-pending-prov protein; Belongs to the actin family. (429 aa)
	ccnd1	Ccnd1-prov protein; Belongs to the cyclin family. (291 aa)
	Frzb.S	Uncharacterized protein. (319 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	Lrp2.L	Uncharacterized protein. (4658 aa)
	Frzb-1	Uncharacterized protein. (319 aa)
	znf804a	C2H2-type domain-containing protein. (1129 aa)
	fzd7	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (549 aa)
	daam1	Uncharacterized protein. (1077 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	Notch1.S	Uncharacterized protein. (2524 aa)
	notch1	Uncharacterized protein. (2521 aa)
	wnt11b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	wnt4-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	A0A1L8FQM4	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (429 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	Shh.L	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (444 aa)
	en2	Homeobox protein engrailed-like. (265 aa)
	Fzd8.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	fzd3	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa)
	vrk2	Protein kinase domain-containing protein. (564 aa)
	ryk	Uncharacterized protein. (596 aa)
	Dkk3.S	Dickkopf_N domain-containing protein. (257 aa)
	lrp8	Uncharacterized protein. (933 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	lrp8-2	Uncharacterized protein. (941 aa)
	A0A1L8GQJ5	Uncharacterized protein. (161 aa)
	Cacna1c.S	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2146 aa)
	sfrp1	Uncharacterized protein. (311 aa)
	Ptprz1.L	Uncharacterized protein. (2259 aa)
	reln	Uncharacterized protein. (3461 aa)
	Sfrp1.L	Uncharacterized protein. (311 aa)
	bcl9	BCL9 domain-containing protein. (1473 aa)
	A0A1L8H5Q6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
	Ca4.S	Alpha-carbonic anhydrase domain-containing protein; Belongs to the alpha-carbonic anhydrase family. (313 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	Lrp1.S	Uncharacterized protein. (4544 aa)
	Bcl9.L	BCL9 domain-containing protein. (1387 aa)
	Csmd1.L	Uncharacterized protein. (406 aa)
	Wnt1.L	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FQM4	Lrp2.L	A0A1L8FQM4	A0A1L8EWA8	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Uncharacterized protein.	0.720
A0A1L8FQM4	Notch1.S	A0A1L8FQM4	A0A1L8F124	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Uncharacterized protein.	0.775
A0A1L8FQM4	Wnt1.L	A0A1L8FQM4	A0A1L8HHR8	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.585
A0A1L8FQM4	actl6a	A0A1L8FQM4	Q7ZYI5	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Baf53a-pending-prov protein; Belongs to the actin family.	0.489
A0A1L8FQM4	ccnd1	A0A1L8FQM4	Q8AVQ4	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Ccnd1-prov protein; Belongs to the cyclin family.	0.412
A0A1L8FQM4	ctnnb1	A0A1L8FQM4	Q63ZT4	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Beta-catenin protein.	0.657
A0A1L8FQM4	dkk1-2	A0A1L8FQM4	O57464	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Dickkopf homolog 1.	0.464
A0A1L8FQM4	notch1	A0A1L8FQM4	A0A1L8F627	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Uncharacterized protein.	0.776
A0A1L8FQM4	wnt1	A0A1L8FQM4	A0A1L8H9S8	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.567
A0A1L8FQM4	wnt11	A0A1L8FQM4	A0A1L8HJX1	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.408
A0A1L8FQM4	wnt11b	A0A1L8FQM4	A0A1L8F6W4	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.408
A0A1L8FQM4	wnt3a	A0A1L8FQM4	A0A1L8FUX8	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.554
A0A1L8GQJ5	Ptprz1.L	A0A1L8GQJ5	A0A1L8GYX6	Uncharacterized protein.	Uncharacterized protein.	0.977
A0A1L8H5Q6	A0A1L8HXA8	A0A1L8H5Q6	A0A1L8HXA8	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.407
A0A1L8H5Q6	Axin1.S	A0A1L8H5Q6	A0A1L8ER48	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.999
A0A1L8H5Q6	Bcl9.L	A0A1L8H5Q6	A0A1L8HC43	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	BCL9 domain-containing protein.	0.477
A0A1L8H5Q6	Fzd8.L	A0A1L8H5Q6	A0A1L8FVD0	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.556
A0A1L8H5Q6	Lrp5.L	A0A1L8H5Q6	A0A1L8GJX4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.896
A0A1L8H5Q6	Notch1.S	A0A1L8H5Q6	A0A1L8F124	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.502
A0A1L8H5Q6	Sfrp1.L	A0A1L8H5Q6	A0A1L8H1S5	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.551