75 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fzd2	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
	rplp0-2	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (315 aa)
	idh1	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (415 aa)
	tbp	LOC503680 protein. (296 aa)
	cdh11-2	Cadherin; Cadherins are calcium-dependent cell adhesion proteins. (794 aa)
	vegfa	Vascular endothelial growth factor 196; Belongs to the PDGF/VEGF growth factor family. (194 aa)
	Bmp1	Metalloendopeptidase. (977 aa)
	xfz8	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	fz3	Fz3 protein; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa)
	lpar1-2	Lysophosphatidic acid G-protein-coupled receptor 2; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	cnr1-2	Cannabinoid receptor; Involved in cannabinoid-induced CNS effects. Belongs to the G-protein coupled receptor 1 family. (470 aa)
	gprc5b-2	Retinoic acid-inducible gene 2. (387 aa)
	F2rl1.L	G_PROTEIN_RECEP_F1_2 domain-containing protein. (390 aa)
	F2r.L	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (419 aa)
	UNG	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (304 aa)
	rplp0	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (314 aa)
	Egf.L	Uncharacterized protein. (1031 aa)
	f2r	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (418 aa)
	lpar1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	qrfpr	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (422 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	ednrb-2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (431 aa)
	adgrb2	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (1465 aa)
	celsr2	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (2911 aa)
	ednrb	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (431 aa)
	Adgrb2.S	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (1432 aa)
	gpr37l1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (453 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	s1pr5-2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (384 aa)
	bmp1	Metalloendopeptidase. (976 aa)
	s1pr5	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (384 aa)
	gpr19	G_PROTEIN_RECEP_F1_2 domain-containing protein. (415 aa)
	oxtr	G_PROTEIN_RECEP_F1_2 domain-containing protein. (391 aa)
	adgrg1	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (642 aa)
	adgrl2-2	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (1452 aa)
	lgr4	G_PROTEIN_RECEP_F1_2 domain-containing protein. (953 aa)
	chrm4-2	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (506 aa)
	adgrl2	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (1448 aa)
	chrm4	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (511 aa)
	Lgr4.S	G_PROTEIN_RECEP_F1_2 domain-containing protein. (956 aa)
	drd4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (414 aa)
	GFM1	Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mito [...] (965 aa)
	gpr171-2	G_PROTEIN_RECEP_F1_2 domain-containing protein. (314 aa)
	cnr1	Cannabinoid receptor; Involved in cannabinoid-induced CNS effects. Belongs to the G-protein coupled receptor 1 family. (470 aa)
	fzd3	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa)
	gpr171	G_PROTEIN_RECEP_F1_2 domain-containing protein. (322 aa)
	fzd6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (724 aa)
	ramp3	Uncharacterized protein. (147 aa)
	lancl2-2	Uncharacterized protein. (441 aa)
	fzd1	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa)
	Fzd8.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	Shh.L	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (444 aa)
	Fzd6.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (715 aa)
	lancl2	Uncharacterized protein. (441 aa)
	calcr	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (476 aa)
	gpr153-2	G_PROTEIN_RECEP_F1_2 domain-containing protein. (651 aa)
	cxcl12	SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (89 aa)
	C1s.L	Uncharacterized protein; Belongs to the peptidase S1 family. (687 aa)
	gpr153	G_PROTEIN_RECEP_F1_2 domain-containing protein. (649 aa)
	nes-2	IF rod domain-containing protein; Belongs to the intermediate filament family. (1954 aa)
	Thbs2.L	Uncharacterized protein. (1176 aa)
	gabbr1	Uncharacterized protein. (980 aa)
	Endog.L	Endonuclease. (290 aa)
	notch1	Uncharacterized protein. (2521 aa)
	nes	IF rod domain-containing protein; Belongs to the intermediate filament family. (1875 aa)
	Notch1.S	Uncharacterized protein. (2524 aa)
	calcrl	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (480 aa)
	fzd7	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (549 aa)
	Lancl1.L	Uncharacterized protein. (402 aa)
	ramp1-2	Uncharacterized protein. (168 aa)
	Cxcr4.L	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (450 aa)
	gprc5b	G_PROTEIN_RECEP_F3_4 domain-containing protein. (387 aa)
	fzd5	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
	ramp1	Uncharacterized protein. (165 aa)
	cxcr4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (358 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adgrb2.S	F2rl1.L	A0A1L8H7U4	A0A1L8I253	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.624
Adgrb2.S	chrm4	A0A1L8H7U4	A0A1L8GDU2	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	0.476
Adgrb2.S	chrm4-2	A0A1L8H7U4	A0A1L8GIV8	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	0.476
Adgrb2.S	gpr153	A0A1L8H7U4	A0A1L8FGE8	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.807
Adgrb2.S	gpr153-2	A0A1L8H7U4	A0A1L8FMK9	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.807
Adgrb2.S	gpr171	A0A1L8H7U4	A0A1L8G4C5	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.428
Adgrb2.S	gpr171-2	A0A1L8H7U4	A0A1L8GAK0	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.428
Adgrb2.S	gpr19	A0A1L8H7U4	A0A1L8GQM3	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.622
Adgrb2.S	gprc5b	A0A1L8H7U4	A0A1L8EQC4	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	G_PROTEIN_RECEP_F3_4 domain-containing protein.	0.577
Adgrb2.S	gprc5b-2	A0A1L8H7U4	A6MUD7	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Retinoic acid-inducible gene 2.	0.573
Bmp1	C1s.L	B7ZS79	A0A1L8FIG6	Metalloendopeptidase.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.476
C1s.L	Bmp1	A0A1L8FIG6	B7ZS79	Uncharacterized protein; Belongs to the peptidase S1 family.	Metalloendopeptidase.	0.476
C1s.L	Egf.L	A0A1L8FIG6	A0A1L8HUT3	Uncharacterized protein; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.442
C1s.L	Thbs2.L	A0A1L8FIG6	A0A1L8FB81	Uncharacterized protein; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.404
C1s.L	bmp1	A0A1L8FIG6	A0A1L8H230	Uncharacterized protein; Belongs to the peptidase S1 family.	Metalloendopeptidase.	0.474
C1s.L	ednrb	A0A1L8FIG6	A0A1L8H972	Uncharacterized protein; Belongs to the peptidase S1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.458
C1s.L	ednrb-2	A0A1L8FIG6	A0A1L8HHC0	Uncharacterized protein; Belongs to the peptidase S1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.458
Cxcr4.L	Egf.L	A0A1L8EVR7	A0A1L8HUT3	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.650
Cxcr4.L	Notch1.S	A0A1L8EVR7	A0A1L8F124	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.534
Cxcr4.L	Shh.L	A0A1L8EVR7	A0A1L8FV87	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.432