52 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ccna1.S	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (418 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	Hus1	Checkpoint protein; Belongs to the HUS1 family. (282 aa)
	ccnd1	Ccnd1-prov protein; Belongs to the cyclin family. (291 aa)
	prim1	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
	ccna2	MGC130969 protein; Belongs to the cyclin family. (415 aa)
	Clspn.S	Claspin. (1286 aa)
	Rad17.L	Uncharacterized protein. (674 aa)
	cdc45	Uncharacterized protein. (567 aa)
	Chek2.L	Uncharacterized protein. (392 aa)
	primpol	Uncharacterized protein. (675 aa)
	Ccna2.S	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (415 aa)
	Ccna1.L	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (421 aa)
	Recql4.L	Uncharacterized protein. (1504 aa)
	Cdc6.L	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (645 aa)
	Dbf4b.L	DBF4-type domain-containing protein. (784 aa)
	Eme1.L	ERCC4 domain-containing protein. (411 aa)
	Exo1.S	Uncharacterized protein. (734 aa)
	mdc1	Uncharacterized protein. (2103 aa)
	Wdhd1.L	Uncharacterized protein. (1127 aa)
	Dna2.S	Uncharacterized protein. (1053 aa)
	Mcmbp.L	Uncharacterized protein. (704 aa)
	Cdc25a.S	Rhodanese domain-containing protein. (172 aa)
	dbf4	Uncharacterized protein. (661 aa)
	topbp1	Uncharacterized protein. (1573 aa)
	Prkdc.L	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (4146 aa)
	Gmnc.S	Uncharacterized protein. (316 aa)
	pik3cb	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	mcm9	MCM domain-containing protein; Belongs to the MCM family. (1143 aa)
	Atr.L	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2654 aa)
	pik3cb-2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	fen1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (382 aa)
	Ccne1.S	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (408 aa)
	atrip	Uncharacterized protein. (801 aa)
	mcm2	DNA helicase; Belongs to the MCM family. (885 aa)
	fen1-2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (382 aa)
	mus81	ERCC4 domain-containing protein. (613 aa)
	ccne1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (408 aa)
	Ccnb1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (397 aa)
	Rad26	Uncharacterized protein. (798 aa)
	Mcm2.L	DNA helicase; Belongs to the MCM family. (886 aa)
	Tipin.S	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (361 aa)
	pik3cg	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1115 aa)
	Cdc25c1	Rhodanese domain-containing protein. (550 aa)
	rad50	Zinc-hook domain-containing protein. (1311 aa)
	rad50-2	Zinc-hook domain-containing protein. (1312 aa)
	mcm10	Mcm10 domain-containing protein. (860 aa)
	tipin	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (362 aa)
	Cdk2.S	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
	A0A1L8H9R2	Uncharacterized protein. (1288 aa)
	Cdk4.L	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (348 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8H9R2	Atr.L	A0A1L8H9R2	A0A1L8GAP7	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.813
A0A1L8H9R2	Cdc6.L	A0A1L8H9R2	A0A1L8ES00	Uncharacterized protein.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.679
A0A1L8H9R2	Chek2.L	A0A1L8H9R2	A0A1L8I0A0	Uncharacterized protein.	Uncharacterized protein.	0.779
A0A1L8H9R2	Clspn.S	A0A1L8H9R2	F8WKR8	Uncharacterized protein.	Claspin.	0.997
A0A1L8H9R2	Dbf4b.L	A0A1L8H9R2	A0A1L8ESD2	Uncharacterized protein.	DBF4-type domain-containing protein.	0.786
A0A1L8H9R2	Dna2.S	A0A1L8H9R2	A0A1L8FF41	Uncharacterized protein.	Uncharacterized protein.	0.740
A0A1L8H9R2	Exo1.S	A0A1L8H9R2	A0A1L8F3G5	Uncharacterized protein.	Uncharacterized protein.	0.806
A0A1L8H9R2	Hus1	A0A1L8H9R2	Q8JHD8	Uncharacterized protein.	Checkpoint protein; Belongs to the HUS1 family.	0.834
A0A1L8H9R2	Mcm2.L	A0A1L8H9R2	A0A1L8GPN4	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.968
A0A1L8H9R2	Rad17.L	A0A1L8H9R2	A0A1L8I1Y0	Uncharacterized protein.	Uncharacterized protein.	0.759
A0A1L8H9R2	Rad26	A0A1L8H9R2	A0A1L8GP12	Uncharacterized protein.	Uncharacterized protein.	0.632
A0A1L8H9R2	Recql4.L	A0A1L8H9R2	A0A1L8HBS7	Uncharacterized protein.	Uncharacterized protein.	0.864
A0A1L8H9R2	Tipin.S	A0A1L8H9R2	A0A1L8GSF3	Uncharacterized protein.	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.999
A0A1L8H9R2	Wdhd1.L	A0A1L8H9R2	A0A1L8F9Z9	Uncharacterized protein.	Uncharacterized protein.	0.998
A0A1L8H9R2	atrip	A0A1L8H9R2	A0A1L8GH95	Uncharacterized protein.	Uncharacterized protein.	0.632
A0A1L8H9R2	cdc45	A0A1L8H9R2	A0A1L8I0M4	Uncharacterized protein.	Uncharacterized protein.	0.990
A0A1L8H9R2	dbf4	A0A1L8H9R2	A0A1L8FVR6	Uncharacterized protein.	Uncharacterized protein.	0.792
A0A1L8H9R2	fen1	A0A1L8H9R2	A0A1L8GDJ8	Uncharacterized protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.837
A0A1L8H9R2	fen1-2	A0A1L8H9R2	A0A1L8GJ67	Uncharacterized protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.837
A0A1L8H9R2	mcm10	A0A1L8H9R2	A0A1L8GZD7	Uncharacterized protein.	Mcm10 domain-containing protein.	0.899