STRINGSTRING
fen1-2 fen1-2 plk1 plk1 A0A1L8F1L3 A0A1L8F1L3 Exo1.S Exo1.S mdc1 mdc1 Tdp1.L Tdp1.L rad51 rad51 smc3 smc3 Dna2.S Dna2.S A0A1L8FI26 A0A1L8FI26 rbbp8 rbbp8 topbp1 topbp1 Rbbp8.L Rbbp8.L Sod2.S Sod2.S Msh6.L Msh6.L msh2 msh2 A0A1L8G820 A0A1L8G820 Smc4.L Smc4.L fen1 fen1 top1.2 top1.2 atrip atrip ddb2 ddb2 Rad26 Rad26 fancd2 fancd2 Tipin.S Tipin.S Tdg.S Tdg.S rad50 rad50 smc1b smc1b rad50-2 rad50-2 Neil1.L Neil1.L tipin tipin Tp53.L Tp53.L A0A1L8H9R2 A0A1L8H9R2 Smug1.L Smug1.L Rnf4-a Rnf4-a Xpa.L Xpa.L smc2 smc2 Chek2.L Chek2.L cdc45 cdc45 Rad17.L Rad17.L mlh1 mlh1 PIK3R1 PIK3R1 Clspn.S Clspn.S rnf4 rnf4 rad9a rad9a Hus1 Hus1 pcna pcna sumo2 sumo2 Plk1.S Plk1.S top1.1 top1.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fen1-2Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (382 aa)
plk1Serine/threonine-protein kinase PLK. (598 aa)
A0A1L8F1L3Structural maintenance of chromosomes protein. (1232 aa)
Exo1.SUncharacterized protein. (734 aa)
mdc1Uncharacterized protein. (2103 aa)
Tdp1.LUncharacterized protein. (597 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa)
smc3Structural maintenance of chromosomes protein. (1209 aa)
Dna2.SUncharacterized protein. (1053 aa)
A0A1L8FI26Structural maintenance of chromosomes protein. (1214 aa)
rbbp8Uncharacterized protein. (846 aa)
topbp1Uncharacterized protein. (1573 aa)
Rbbp8.LUncharacterized protein. (856 aa)
Sod2.SSuperoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (226 aa)
Msh6.LDNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1340 aa)
msh2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa)
A0A1L8G820Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
Smc4.LStructural maintenance of chromosomes protein. (1299 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (382 aa)
top1.2DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (770 aa)
atripUncharacterized protein. (801 aa)
ddb2WD_REPEATS_REGION domain-containing protein. (489 aa)
Rad26Uncharacterized protein. (798 aa)
fancd2Uncharacterized protein. (1445 aa)
Tipin.STIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (361 aa)
Tdg.SUDG domain-containing protein. (440 aa)
rad50Zinc-hook domain-containing protein. (1311 aa)
smc1bStructural maintenance of chromosomes protein. (1228 aa)
rad50-2Zinc-hook domain-containing protein. (1312 aa)
Neil1.LFPG_CAT domain-containing protein. (409 aa)
tipinTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (362 aa)
Tp53.LP53 domain-containing protein. (137 aa)
A0A1L8H9R2Uncharacterized protein. (1288 aa)
Smug1.LUncharacterized protein. (277 aa)
Rnf4-aRING-type domain-containing protein. (190 aa)
Xpa.LXPA_C domain-containing protein. (265 aa)
smc2Structural maintenance of chromosomes protein. (1202 aa)
Chek2.LUncharacterized protein. (392 aa)
cdc45Uncharacterized protein. (567 aa)
Rad17.LUncharacterized protein. (674 aa)
mlh1DNA mismatch repair protein MutL-homolog 1. (750 aa)
PIK3R1Phosphoinositide-3-kinase. (722 aa)
Clspn.SClaspin. (1286 aa)
rnf4LOC495944 protein. (190 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
Hus1Checkpoint protein; Belongs to the HUS1 family. (282 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
sumo2Small ubiquitin-related modifier. (95 aa)
Plk1.SSerine/threonine-protein kinase PLK. (598 aa)
top1.1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (821 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
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