24 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ctnnb1	Beta-catenin protein. (781 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	actl6a	Baf53a-pending-prov protein; Belongs to the actin family. (429 aa)
	prkcz	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (590 aa)
	prickle3-b	Prickle planar cell polarity protein 3-B; Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules. Proteins of the core module include the proteins Frizzled (Fz), Disheveled (Dsh), Van Gogh (Vang), Prickle (Pk), Flamingo (Fmi, Celsr) and Diego (Dgo). The core module proteins develop subcellular asymmetry, accumulating in two groups on opposite sides of epithelial cells. D [...] (536 aa)
	wnt11b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	Cdh3.S	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (880 aa)
	Prkci.L	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (588 aa)
	Esr1.S	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	Ptk2.L	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1097 aa)
	fzd6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (724 aa)
	Ptk2.S	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1065 aa)
	Fzd6.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (715 aa)
	prickle2	Uncharacterized protein. (833 aa)
	cdh1	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (871 aa)
	cdh3	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
	prickle2-2	Uncharacterized protein. (833 aa)
	prickle1	Uncharacterized protein. (835 aa)
	Prickle1.L	Uncharacterized protein. (832 aa)
	vangl1	Vang-like protein. (503 aa)
	vangl1-2	Vang-like protein. (499 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	sec24b	Uncharacterized protein. (1094 aa)
	sec24b-2	Uncharacterized protein. (1098 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cdh3.S	Esr1.S	A0A1L8GET9	A0A1L8G265	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.563
Cdh3.S	Prkci.L	A0A1L8GET9	A0A1L8GAK2	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.694
Cdh3.S	Ptk2.L	A0A1L8GET9	A0A1L8G031	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.584
Cdh3.S	Ptk2.S	A0A1L8GET9	A0A1L8FTZ0	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.584
Cdh3.S	actl6a	A0A1L8GET9	Q7ZYI5	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Baf53a-pending-prov protein; Belongs to the actin family.	0.931
Cdh3.S	cdh1	A0A1L8GET9	A0A1L8GKV4	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.903
Cdh3.S	cdh3	A0A1L8GET9	A0A1L8GKW6	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.901
Cdh3.S	ctnnb1	A0A1L8GET9	Q63ZT4	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Beta-catenin protein.	0.999
Cdh3.S	esr1	A0A1L8GET9	Q6W5G7	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.563
Cdh3.S	prkcz	A0A1L8GET9	A0A1L8FM28	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.406
Cdh3.S	vangl1	A0A1L8GET9	A0A1L8H5Y3	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Vang-like protein.	0.400
Cdh3.S	wnt11	A0A1L8GET9	A0A1L8HJX1	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.551
Cdh3.S	wnt11b	A0A1L8GET9	A0A1L8F6W4	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.557
Esr1.S	Cdh3.S	A0A1L8G265	A0A1L8GET9	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.563
Esr1.S	Ptk2.L	A0A1L8G265	A0A1L8G031	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.568
Esr1.S	Ptk2.S	A0A1L8G265	A0A1L8FTZ0	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.568
Esr1.S	actl6a	A0A1L8G265	Q7ZYI5	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Baf53a-pending-prov protein; Belongs to the actin family.	0.686
Esr1.S	cdh1	A0A1L8G265	A0A1L8GKV4	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.565
Esr1.S	cdh3	A0A1L8G265	A0A1L8GKW6	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.563
Esr1.S	ctnnb1	A0A1L8G265	Q63ZT4	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Beta-catenin protein.	0.759