STRINGSTRING
fzd7 fzd7 nfatc2 nfatc2 stat3.1 stat3.1 Stat3.2.L Stat3.2.L Axin1.S Axin1.S fzd5 fzd5 A0A1L8EPW6 A0A1L8EPW6 A0A1L8ENI4 A0A1L8ENI4 Nfatc2.S Nfatc2.S fzd2 fzd2 A0A1L8EKE2 A0A1L8EKE2 rspo3 rspo3 A0A1L8G7M0 A0A1L8G7M0 tgfb2-2 tgfb2-2 rock2 rock2 psen2 psen2 tgfb2 tgfb2 Rock1.L Rock1.L fzd1 fzd1 Fzd8.L Fzd8.L Shh.L Shh.L wnt3a wnt3a Rock1.S Rock1.S Bcl2.S Bcl2.S axin2 axin2 A0A1L8FND1 A0A1L8FND1 wnt4-2 wnt4-2 Ctnnd1.L Ctnnd1.L dkk1 dkk1 Tcf7l2.L Tcf7l2.L kras kras A0A1L8FGA0 A0A1L8FGA0 wnt4 wnt4 tnks2 tnks2 psen1 psen1 tgfb1-2 tgfb1-2 Agtr2.L Agtr2.L notch1 notch1 tgfb1 tgfb1 Notch1.S Notch1.S A0A1L8EZY9 A0A1L8EZY9 A0A1L8EX52 A0A1L8EX52 A0A1L8EUY4 A0A1L8EUY4 kras-3 kras-3 prkaca prkaca hras hras rhoa rhoa stat5b stat5b myc myc kras-2 kras-2 axin2-2 axin2-2 ctnnb1 ctnnb1 krasl krasl src src dkk1-2 dkk1-2 wnt7b wnt7b fyn-2 fyn-2 PIK3R1 PIK3R1 Stat5a Stat5a xfz8 xfz8 ins-2 ins-2 nf-at nf-at pten pten arvcf-2 arvcf-2 tnks tnks Stat6.L Stat6.L stat2-2 stat2-2 wnt10b wnt10b Rnf43.L Rnf43.L fzd9-2 fzd9-2 Bcl9.L Bcl9.L A0A1L8H9R9 A0A1L8H9R9 stat2 stat2 rnf43 rnf43 fzd9 fzd9 A0A1L8H5Q6 A0A1L8H5Q6 bcl9 bcl9 Tp53.L Tp53.L Sfrp1.L Sfrp1.L Smo.L Smo.L hgf-2 hgf-2 A0A1L8GYX0 A0A1L8GYX0 Lgr5.L Lgr5.L lgr5 lgr5 hgf hgf Smo.S Smo.S sfrp1 sfrp1 Wnt5b.S Wnt5b.S Prkacb.S Prkacb.S cdh3 cdh3 cdh1 cdh1 nfatc3 nfatc3 lgr4 lgr4 prkacb prkacb Cdh3.S Cdh3.S Cdh8.S Cdh8.S Lgr4.S Lgr4.S ins ins Rock2.L Rock2.L ryk ryk fyn fyn
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fzd7Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (549 aa)
nfatc2RHD domain-containing protein. (896 aa)
stat3.1Signal transducer and activator of transcription. (769 aa)
Stat3.2.LSignal transducer and activator of transcription. (760 aa)
Axin1.SUncharacterized protein. (839 aa)
fzd5Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
A0A1L8EPW6Signal transducer and activator of transcription. (750 aa)
A0A1L8ENI4Uncharacterized protein. (815 aa)
Nfatc2.SRHD domain-containing protein. (884 aa)
fzd2Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
A0A1L8EKE2Signal transducer and activator of transcription. (760 aa)
rspo3Uncharacterized protein. (253 aa)
A0A1L8G7M0Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (445 aa)
tgfb2-2Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
rock2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1399 aa)
psen2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (449 aa)
tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
Rock1.LRho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1360 aa)
fzd1Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa)
Fzd8.LUncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
Shh.LHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (444 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
Rock1.SRho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1367 aa)
Bcl2.SBH4_2 domain-containing protein. (253 aa)
axin2Uncharacterized protein. (707 aa)
A0A1L8FND1IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
wnt4-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
Ctnnd1.LUncharacterized protein. (248 aa)
dkk1Dickkopf_N domain-containing protein. (263 aa)
Tcf7l2.LHMG box domain-containing protein. (482 aa)
krasUncharacterized protein. (186 aa)
A0A1L8FGA0Uncharacterized protein. (191 aa)
wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
tnks2Poly [ADP-ribose] polymerase. (1165 aa)
psen1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (433 aa)
tgfb1-2Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
Agtr2.LG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (370 aa)
notch1Uncharacterized protein. (2521 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
Notch1.SUncharacterized protein. (2524 aa)
A0A1L8EZY9Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (433 aa)
A0A1L8EX52Signal transducer and activator of transcription. (1111 aa)
A0A1L8EUY4Uncharacterized protein. (818 aa)
kras-3LOC397771 protein. (186 aa)
prkacacAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
hrasSmall G-protein H-Ras. (189 aa)
rhoaMGC64296 protein. (193 aa)
stat5bSignal transducer and activator of transcription. (781 aa)
mycTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
kras-2Uncharacterized protein. (187 aa)
axin2-2MGC81576 protein. (707 aa)
ctnnb1Beta-catenin protein. (781 aa)
kraslUncharacterized protein. (187 aa)
srcTyrosine-protein kinase. (532 aa)
dkk1-2Dickkopf homolog 1. (259 aa)
wnt7bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
fyn-2Tyrosine-protein kinase. (537 aa)
PIK3R1Phosphoinositide-3-kinase. (722 aa)
Stat5aSignal transducer and activator of transcription. (781 aa)
xfz8Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
ins-2Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
nf-atNuclear factor of activated T-cell. (884 aa)
ptenPhosphatase and tensin homolog S homeolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
arvcf-2Uncharacterized protein. (919 aa)
tnksPoly [ADP-ribose] polymerase. (1298 aa)
Stat6.LSignal transducer and activator of transcription. (791 aa)
stat2-2Signal transducer and activator of transcription. (770 aa)
wnt10bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
Rnf43.LRING-type domain-containing protein. (780 aa)
fzd9-2Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (587 aa)
Bcl9.LBCL9 domain-containing protein. (1387 aa)
A0A1L8H9R9Signal transducer and activator of transcription. (743 aa)
stat2Signal transducer and activator of transcription. (753 aa)
rnf43RING-type domain-containing protein. (664 aa)
fzd9Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (587 aa)
A0A1L8H5Q6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
bcl9BCL9 domain-containing protein. (1473 aa)
Tp53.LP53 domain-containing protein. (137 aa)
Sfrp1.LUncharacterized protein. (311 aa)
Smo.LUncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (815 aa)
hgf-2Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
A0A1L8GYX0Uncharacterized protein; Belongs to the DOCK family. (1952 aa)
Lgr5.LG_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
lgr5G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
hgfHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
Smo.SUncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (814 aa)
sfrp1Uncharacterized protein. (311 aa)
Wnt5b.SProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (375 aa)
Prkacb.SUncharacterized protein; Belongs to the protein kinase superfamily. (338 aa)
cdh3Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
cdh1Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (871 aa)
nfatc3RHD domain-containing protein. (885 aa)
lgr4G_PROTEIN_RECEP_F1_2 domain-containing protein. (953 aa)
prkacbUncharacterized protein; Belongs to the protein kinase superfamily. (396 aa)
Cdh3.SUncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (880 aa)
Cdh8.SUncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (810 aa)
Lgr4.SG_PROTEIN_RECEP_F1_2 domain-containing protein. (956 aa)
insInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
Rock2.LRho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1373 aa)
rykUncharacterized protein. (596 aa)
fynTyrosine-protein kinase. (537 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
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