33 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	sumo2	Small ubiquitin-related modifier. (95 aa)
	Sumo1.S	Ubiquitin-like domain-containing protein. (141 aa)
	ube2i	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
	Brca1.L	Uncharacterized protein. (1582 aa)
	sumo2-2	Ubiquitin-like domain-containing protein. (98 aa)
	Sumo1.L	Ubiquitin-like domain-containing protein. (148 aa)
	mdc1	Uncharacterized protein. (2103 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa)
	chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
	chek1-2	Protein kinase domain-containing protein. (510 aa)
	topbp1	Uncharacterized protein. (1573 aa)
	gad1.2	Uncharacterized protein. (542 aa)
	Nbn.L	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (762 aa)
	Atr.L	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2654 aa)
	atrip	Uncharacterized protein. (801 aa)
	Rad26	Uncharacterized protein. (798 aa)
	pias1	Uncharacterized protein. (640 aa)
	Tipin.S	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (361 aa)
	rad50	Zinc-hook domain-containing protein. (1311 aa)
	rad50-2	Zinc-hook domain-containing protein. (1312 aa)
	tipin	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (362 aa)
	Pias1.L	Uncharacterized protein. (649 aa)
	A0A1L8H9R2	Uncharacterized protein. (1288 aa)
	Rpa1.L	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (609 aa)
	nek1	Protein kinase domain-containing protein. (1290 aa)
	Rnf4-a	RING-type domain-containing protein. (190 aa)
	nek1-2	Protein kinase domain-containing protein. (1291 aa)
	Chek2.L	Uncharacterized protein. (392 aa)
	Rad17.L	Uncharacterized protein. (674 aa)
	Clspn.S	Claspin. (1286 aa)
	rnf4	LOC495944 protein. (190 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
	Hus1	Checkpoint protein; Belongs to the HUS1 family. (282 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8H9R2	Atr.L	A0A1L8H9R2	A0A1L8GAP7	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.813
A0A1L8H9R2	Brca1.L	A0A1L8H9R2	A0A1L8ETS4	Uncharacterized protein.	Uncharacterized protein.	0.476
A0A1L8H9R2	Chek2.L	A0A1L8H9R2	A0A1L8I0A0	Uncharacterized protein.	Uncharacterized protein.	0.779
A0A1L8H9R2	Clspn.S	A0A1L8H9R2	F8WKR8	Uncharacterized protein.	Claspin.	0.997
A0A1L8H9R2	Hus1	A0A1L8H9R2	Q8JHD8	Uncharacterized protein.	Checkpoint protein; Belongs to the HUS1 family.	0.834
A0A1L8H9R2	Rad17.L	A0A1L8H9R2	A0A1L8I1Y0	Uncharacterized protein.	Uncharacterized protein.	0.759
A0A1L8H9R2	Rad26	A0A1L8H9R2	A0A1L8GP12	Uncharacterized protein.	Uncharacterized protein.	0.632
A0A1L8H9R2	Rpa1.L	A0A1L8H9R2	A0A1L8HDB4	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.929
A0A1L8H9R2	Tipin.S	A0A1L8H9R2	A0A1L8GSF3	Uncharacterized protein.	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.999
A0A1L8H9R2	atrip	A0A1L8H9R2	A0A1L8GH95	Uncharacterized protein.	Uncharacterized protein.	0.632
A0A1L8H9R2	chek1	A0A1L8H9R2	A0A1L8FFS1	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.933
A0A1L8H9R2	chek1-2	A0A1L8H9R2	A0A1L8FL95	Uncharacterized protein.	Protein kinase domain-containing protein.	0.925
A0A1L8H9R2	mdc1	A0A1L8H9R2	A0A1L8F8K7	Uncharacterized protein.	Uncharacterized protein.	0.497
A0A1L8H9R2	rad51	A0A1L8H9R2	A0A1L8FB28	Uncharacterized protein.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.696
A0A1L8H9R2	rad9a	A0A1L8H9R2	Q7ZZU5	Uncharacterized protein.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.806
A0A1L8H9R2	tipin	A0A1L8H9R2	A0A1L8H168	Uncharacterized protein.	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.999
A0A1L8H9R2	topbp1	A0A1L8H9R2	A0A1L8FWJ6	Uncharacterized protein.	Uncharacterized protein.	0.929
Atr.L	A0A1L8H9R2	A0A1L8GAP7	A0A1L8H9R2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.813
Atr.L	Brca1.L	A0A1L8GAP7	A0A1L8ETS4	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.998
Atr.L	Chek2.L	A0A1L8GAP7	A0A1L8I0A0	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.999