39 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Smad3	Mothers against decapentaplegic homolog. (425 aa)
	Nfatc2.S	RHD domain-containing protein. (884 aa)
	nfatc2	RHD domain-containing protein. (896 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1280 aa)
	rasgrp1	Uncharacterized protein. (814 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	rasgrp1-2	Uncharacterized protein. (811 aa)
	Cdc25a.S	Rhodanese domain-containing protein. (172 aa)
	nfatc1	RHD domain-containing protein. (955 aa)
	nfatc1-2	RHD domain-containing protein. (933 aa)
	pik3cb	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	pik3cb-2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	Ccne1.S	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (408 aa)
	nfatc3	RHD domain-containing protein. (885 aa)
	ccne1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (408 aa)
	Cdkn1b.S	Uncharacterized protein. (152 aa)
	skp1	Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
	pik3cg	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1115 aa)
	Cdc25c1	Rhodanese domain-containing protein. (550 aa)
	skp1-2	Uncharacterized protein; Belongs to the SKP1 family. (221 aa)
	Cdk2.S	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
	Ccna1.S	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (418 aa)
	Ccna1.L	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (421 aa)
	Ccna2.S	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (415 aa)
	cdkn2b	ANK_REP_REGION domain-containing protein. (125 aa)
	syk	Tyrosine-protein kinase. (605 aa)
	Plcg1.S	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1260 aa)
	pten	Phosphatase and tensin homolog S homeolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
	nf-at	Nuclear factor of activated T-cell. (884 aa)
	mapk14	Mitogen-activated protein kinase. (361 aa)
	cdkn2b-2	MGC154405 protein. (125 aa)
	src	Tyrosine-protein kinase. (532 aa)
	ccna2	MGC130969 protein; Belongs to the cyclin family. (415 aa)
	zap70	Tyrosine-protein kinase. (617 aa)
	ptpn11b	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	cpt1al	MGC53498 protein; Belongs to the carnitine/choline acetyltransferase family. (768 aa)
	smad3	Mothers against decapentaplegic homolog. (425 aa)
	Ptpn11.S	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ccna1.L	Ccna1.S	A0A1L8HIV0	A0A1L8HAP9	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.415
Ccna1.L	Ccna2.S	A0A1L8HIV0	A0A1L8HLX1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.704
Ccna1.L	Ccne1.S	A0A1L8HIV0	A0A1L8GF58	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.921
Ccna1.L	Cdc25a.S	A0A1L8HIV0	A0A1L8FQA3	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Rhodanese domain-containing protein.	0.860
Ccna1.L	Cdc25c1	A0A1L8HIV0	A0A1L8GUV6	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Rhodanese domain-containing protein.	0.918
Ccna1.L	Cdk2.S	A0A1L8HIV0	A0A1L8H9N1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.999
Ccna1.L	Cdkn1b.S	A0A1L8HIV0	A0A1L8GQW1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Uncharacterized protein.	0.996
Ccna1.L	ccna2	A0A1L8HIV0	Q3KQ49	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	MGC130969 protein; Belongs to the cyclin family.	0.700
Ccna1.L	ccne1	A0A1L8HIV0	A0A1L8GL65	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.920
Ccna1.L	cdkn2b	A0A1L8HIV0	A0A1L8HP31	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	ANK_REP_REGION domain-containing protein.	0.415
Ccna1.L	cdkn2b-2	A0A1L8HIV0	Q0IHF2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	MGC154405 protein.	0.415
Ccna1.L	skp1	A0A1L8HIV0	A0A1L8GR29	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Uncharacterized protein; Belongs to the SKP1 family.	0.969
Ccna1.L	skp1-2	A0A1L8HIV0	A0A1L8GWN2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Uncharacterized protein; Belongs to the SKP1 family.	0.969
Ccna1.S	Ccna1.L	A0A1L8HAP9	A0A1L8HIV0	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.415
Ccna1.S	Ccna2.S	A0A1L8HAP9	A0A1L8HLX1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.709
Ccna1.S	Ccne1.S	A0A1L8HAP9	A0A1L8GF58	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.924
Ccna1.S	Cdc25a.S	A0A1L8HAP9	A0A1L8FQA3	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Rhodanese domain-containing protein.	0.844
Ccna1.S	Cdc25c1	A0A1L8HAP9	A0A1L8GUV6	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Rhodanese domain-containing protein.	0.909
Ccna1.S	Cdk2.S	A0A1L8HAP9	A0A1L8H9N1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.999
Ccna1.S	Cdkn1b.S	A0A1L8HAP9	A0A1L8GQW1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Uncharacterized protein.	0.996