79 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ccnd1	Ccnd1-prov protein; Belongs to the cyclin family. (291 aa)
	ror2-2	Receptor tyrosine kinase Xror2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
	sfrp2-2	Sfrp2-prov protein. (298 aa)
	hnrnpk-2	Hnrpk protein. (399 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	hif1a	Hif1a-prov protein. (802 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase. (159 aa)
	fos-2	MGC80305 protein. (368 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	wif1-2	Wnt inhibitory factor-1. (374 aa)
	wnt6-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	fos	BZIP domain-containing protein. (369 aa)
	pten	Phosphatase and tensin homolog S homeolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
	pik3c3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (886 aa)
	pxn	Uncharacterized protein; Belongs to the paxillin family. (542 aa)
	hnrnpk	Uncharacterized protein. (399 aa)
	Tcf3.L	BHLH domain-containing protein. (709 aa)
	sfrp2	Uncharacterized protein. (295 aa)
	ror2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	Mmp7.L	ZnMc domain-containing protein. (259 aa)
	Wnt1.L	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	cdkn1a	Uncharacterized protein. (261 aa)
	tmprss2	Uncharacterized protein; Belongs to the peptidase S1 family. (476 aa)
	Fzd4.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
	PR-2	Uncharacterized protein. (730 aa)
	Mmp13.S	ZnMc domain-containing protein. (258 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	A0A1L8H5Q6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	Sfrp1.L	Uncharacterized protein. (311 aa)
	mdm2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (489 aa)
	wif1	Uncharacterized protein. (374 aa)
	Ascl1.L	BHLH domain-containing protein. (242 aa)
	pik3cg	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1115 aa)
	sfrp1	Uncharacterized protein. (311 aa)
	ep300-2	Uncharacterized protein. (2492 aa)
	Jun.L	BZIP domain-containing protein; Belongs to the bZIP family. (314 aa)
	cdh3	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
	cdh1	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (871 aa)
	ep300	Uncharacterized protein. (2495 aa)
	Cdh3.S	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (880 aa)
	Dkk3.S	Dickkopf_N domain-containing protein. (257 aa)
	pik3cb-2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	Foxa2.L	Fork-head domain-containing protein. (434 aa)
	tgfb2-2	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
	pik3cb	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	Esr1.S	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
	fzd6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (724 aa)
	sfrp4	Uncharacterized protein. (353 aa)
	fzd1	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	Myc.S	Myc_N domain-containing protein. (176 aa)
	Fzd6.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (715 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	foxa1-2	Fork-head domain-containing protein. (429 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	wnt11b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	Cdk20.S	Protein kinase domain-containing protein. (376 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	Hif-1a	Uncharacterized protein. (800 aa)
	foxa1	Fork-head domain-containing protein. (427 aa)
	Tgfb1i1.L	Uncharacterized protein; Belongs to the paxillin family. (501 aa)
	crebbp-2	Uncharacterized protein. (2453 aa)
	fzd7	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (549 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	A0A1L8ES96	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (554 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	Tgfb1i1.S	Uncharacterized protein; Belongs to the paxillin family. (561 aa)
	crebbp	Uncharacterized protein. (2424 aa)
	fzd2	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
	c-Jun	C-Jun protein; Belongs to the bZIP family. (312 aa)
	pin1-2	Peptidyl-prolyl cis-trans isomerase. (159 aa)
	pxn-2	LOC397826 protein; Belongs to the paxillin family. (539 aa)
	pgr	Progesterone receptor. (732 aa)
	tcea1	TFIIS elongation factor. (303 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ES96	Axin1.S	A0A1L8ES96	A0A1L8ER48	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.528
A0A1L8ES96	Fzd6.S	A0A1L8ES96	A0A1L8FTP5	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.411
A0A1L8ES96	Sfrp1.L	A0A1L8ES96	A0A1L8H1S5	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.678
A0A1L8ES96	Wnt1.L	A0A1L8ES96	A0A1L8HHR8	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.885
A0A1L8ES96	ctnnb1	A0A1L8ES96	Q63ZT4	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Beta-catenin protein.	0.702
A0A1L8ES96	fzd6	A0A1L8ES96	A0A1L8FZR1	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.412
A0A1L8ES96	ror2	A0A1L8ES96	A0A1L8HPI6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.848
A0A1L8ES96	ror2-2	A0A1L8ES96	Q8AV69	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase Xror2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.848
A0A1L8ES96	sfrp1	A0A1L8ES96	A0A1L8GRT5	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.679
A0A1L8ES96	sfrp2	A0A1L8ES96	A0A1L8HUI3	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.708
A0A1L8ES96	sfrp2-2	A0A1L8ES96	Q7ZXM6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Sfrp2-prov protein.	0.708
A0A1L8ES96	sfrp4	A0A1L8ES96	A0A1L8FWW4	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.654
A0A1L8ES96	wnt1	A0A1L8ES96	A0A1L8H9S8	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.885
A0A1L8ES96	wnt11	A0A1L8ES96	A0A1L8HJX1	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.880
A0A1L8ES96	wnt11b	A0A1L8ES96	A0A1L8F6W4	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.878
A0A1L8ES96	wnt3a	A0A1L8ES96	A0A1L8FUX8	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.883
A0A1L8ES96	wnt6	A0A1L8ES96	A0A1L8EVQ7	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.815
A0A1L8ES96	wnt6-2	A0A1L8ES96	B0FK91	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.815
A0A1L8H5Q6	Axin1.S	A0A1L8H5Q6	A0A1L8ER48	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.999
A0A1L8H5Q6	Cdh3.S	A0A1L8H5Q6	A0A1L8GET9	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.588