53 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (156 aa)
	pik3cg	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1115 aa)
	bmp10	TGF_BETA_2 domain-containing protein. (421 aa)
	nfatc3	RHD domain-containing protein. (885 aa)
	Fgf4.L	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (237 aa)
	pik3cb-2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	bcl2l11-2	Uncharacterized protein. (194 aa)
	gata4	Uncharacterized protein. (392 aa)
	pik3cb	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	bcl2l11	Uncharacterized protein. (194 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	Nfatc2.S	RHD domain-containing protein. (884 aa)
	erbb2	Receptor protein-tyrosine kinase. (1299 aa)
	nfatc2	RHD domain-containing protein. (896 aa)
	Notch1.S	Uncharacterized protein. (2524 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	notch1	Uncharacterized protein. (2521 aa)
	rxra	Uncharacterized protein. (488 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	nfatc1	RHD domain-containing protein. (955 aa)
	Sox17a.S	Uncharacterized protein. (377 aa)
	nfatc1-2	RHD domain-containing protein. (933 aa)
	sox17b.1	Uncharacterized protein. (373 aa)
	sox17b.1-2	Uncharacterized protein. (373 aa)
	src	Tyrosine-protein kinase. (532 aa)
	vegfa	Vascular endothelial growth factor 196; Belongs to the PDGF/VEGF growth factor family. (194 aa)
	tbx5-2	T-box transcription factor Tbx5. (519 aa)
	nf-at	Nuclear factor of activated T-cell. (884 aa)
	bmp4	Bone morphogenetic protein 4. (401 aa)
	spry1-2	Sprouty 1. (319 aa)
	A0A1L8HW99	Uncharacterized protein. (576 aa)
	pitx2	Homeobox protein. (323 aa)
	ptpn11b	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	gata4-2	MGC81427 protein. (394 aa)
	efnb2	Efnb2a protein; Belongs to the ephrin family. (329 aa)
	rhoa	MGC64296 protein. (193 aa)
	actl6a	Baf53a-pending-prov protein; Belongs to the actin family. (429 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	bmp4-2	Bone morphogenetic protein 4. (400 aa)
	Ptpn11.S	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
	lefty	Left-right determination factor. (366 aa)
	pkd2	EF-hand domain-containing protein. (947 aa)
	Egf.L	Uncharacterized protein. (1031 aa)
	Pitx2.S	Homeobox protein. (326 aa)
	spry1	Uncharacterized protein. (342 aa)
	tbx5	Uncharacterized protein. (519 aa)
	tek	Uncharacterized protein. (1126 aa)
	Eln1.L	Uncharacterized protein. (904 aa)
	Efnb2.S	Ephrin RBD domain-containing protein; Belongs to the ephrin family. (329 aa)
	bmp10-2	TGF_BETA_2 domain-containing protein. (421 aa)
	fgf1-2	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8HW99	Egf.L	A0A1L8HW99	A0A1L8HUT3	Uncharacterized protein.	Uncharacterized protein.	0.747
A0A1L8HW99	Notch1.S	A0A1L8HW99	A0A1L8F124	Uncharacterized protein.	Uncharacterized protein.	0.515
A0A1L8HW99	bmp10	A0A1L8HW99	A0A1L8GSA3	Uncharacterized protein.	TGF_BETA_2 domain-containing protein.	0.473
A0A1L8HW99	bmp10-2	A0A1L8HW99	A0A1L8H1G9	Uncharacterized protein.	TGF_BETA_2 domain-containing protein.	0.473
A0A1L8HW99	erbb2	A0A1L8HW99	A0A1L8ES20	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.958
A0A1L8HW99	fgf1	A0A1L8HW99	A0A1L8GVD8	Uncharacterized protein.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.486
A0A1L8HW99	fgf1-2	A0A1L8HW99	A0A1L8GXF9	Uncharacterized protein.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.485
A0A1L8HW99	notch1	A0A1L8HW99	A0A1L8F627	Uncharacterized protein.	Uncharacterized protein.	0.514
A0A1L8HW99	src	A0A1L8HW99	Q2TAR1	Uncharacterized protein.	Tyrosine-protein kinase.	0.505
Efnb2.S	Notch1.S	A0A1L8H932	A0A1L8F124	Ephrin RBD domain-containing protein; Belongs to the ephrin family.	Uncharacterized protein.	0.676
Efnb2.S	actl6a	A0A1L8H932	Q7ZYI5	Ephrin RBD domain-containing protein; Belongs to the ephrin family.	Baf53a-pending-prov protein; Belongs to the actin family.	0.480
Efnb2.S	notch1	A0A1L8H932	A0A1L8F627	Ephrin RBD domain-containing protein; Belongs to the ephrin family.	Uncharacterized protein.	0.671
Efnb2.S	rhoa	A0A1L8H932	Q7SZA9	Ephrin RBD domain-containing protein; Belongs to the ephrin family.	MGC64296 protein.	0.618
Efnb2.S	src	A0A1L8H932	Q2TAR1	Ephrin RBD domain-containing protein; Belongs to the ephrin family.	Tyrosine-protein kinase.	0.758
Efnb2.S	tek	A0A1L8H932	A0A1L8HP14	Ephrin RBD domain-containing protein; Belongs to the ephrin family.	Uncharacterized protein.	0.593
Efnb2.S	vegfa	A0A1L8H932	O42572	Ephrin RBD domain-containing protein; Belongs to the ephrin family.	Vascular endothelial growth factor 196; Belongs to the PDGF/VEGF growth factor family.	0.472
Egf.L	A0A1L8HW99	A0A1L8HUT3	A0A1L8HW99	Uncharacterized protein.	Uncharacterized protein.	0.747
Egf.L	Eln1.L	A0A1L8HUT3	A0A1L8HDH2	Uncharacterized protein.	Uncharacterized protein.	0.551
Egf.L	Fgf4.L	A0A1L8HUT3	A0A1L8GIU8	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.578
Egf.L	Notch1.S	A0A1L8HUT3	A0A1L8F124	Uncharacterized protein.	Uncharacterized protein.	0.415