40 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Socs3.S	Uncharacterized protein. (250 aa)
	A0A1L8EKE2	Signal transducer and activator of transcription. (760 aa)
	A0A1L8FND1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
	A0A1L8FKN8	Uncharacterized protein. (183 aa)
	socs3l	Uncharacterized protein. (215 aa)
	A0A1L8EX52	Signal transducer and activator of transcription. (1111 aa)
	stat3.1	Signal transducer and activator of transcription. (769 aa)
	Stat3.2.L	Signal transducer and activator of transcription. (760 aa)
	A0A1L8EPW6	Signal transducer and activator of transcription. (750 aa)
	Ptpn11.S	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
	socs3	MGC81248 protein. (199 aa)
	stat5b	Signal transducer and activator of transcription. (781 aa)
	ptpn11b	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	npy-2	MGC86288 protein. (97 aa)
	lep-2	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	src	Tyrosine-protein kinase. (532 aa)
	LOC398006	Tyrosine-protein kinase receptor. (1362 aa)
	Stat5a	Signal transducer and activator of transcription. (781 aa)
	ins-2	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	Jak2.S	Tyrosine-protein kinase. (1088 aa)
	lif	Uncharacterized protein. (216 aa)
	jak2	Tyrosine-protein kinase. (1129 aa)
	A0A1L8HPW4	Uncharacterized protein. (216 aa)
	Stat6.L	Signal transducer and activator of transcription. (791 aa)
	stat2-2	Signal transducer and activator of transcription. (770 aa)
	A0A1L8H9R9	Signal transducer and activator of transcription. (743 aa)
	stat2	Signal transducer and activator of transcription. (753 aa)
	lep	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	pik3cg	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1115 aa)
	agrp-2	Agouti domain-containing protein. (147 aa)
	agrp	Agouti domain-containing protein. (147 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	Pomc.L	Uncharacterized protein. (282 aa)
	pik3cb-2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	pomc	Uncharacterized protein. (260 aa)
	pik3cb	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	mc4r-2	G_PROTEIN_RECEP_F1_2 domain-containing protein. (334 aa)
	mc4r	G_PROTEIN_RECEP_F1_2 domain-containing protein. (334 aa)
	npy	Uncharacterized protein. (97 aa)
	A0A1L8FND6	Uncharacterized protein. (232 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EKE2	A0A1L8FKN8	A0A1L8EKE2	A0A1L8FKN8	Signal transducer and activator of transcription.	Uncharacterized protein.	0.410
A0A1L8EKE2	A0A1L8FND1	A0A1L8EKE2	A0A1L8FND1	Signal transducer and activator of transcription.	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.431
A0A1L8EKE2	A0A1L8FND6	A0A1L8EKE2	A0A1L8FND6	Signal transducer and activator of transcription.	Uncharacterized protein.	0.450
A0A1L8EKE2	A0A1L8HPW4	A0A1L8EKE2	A0A1L8HPW4	Signal transducer and activator of transcription.	Uncharacterized protein.	0.449
A0A1L8EKE2	Jak2.S	A0A1L8EKE2	A0A310U8T2	Signal transducer and activator of transcription.	Tyrosine-protein kinase.	0.984
A0A1L8EKE2	Ptpn11.S	A0A1L8EKE2	Q92124	Signal transducer and activator of transcription.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.471
A0A1L8EKE2	Socs3.S	A0A1L8EKE2	A0A1L8EM41	Signal transducer and activator of transcription.	Uncharacterized protein.	0.517
A0A1L8EKE2	ins	A0A1L8EKE2	A0A1L8GD41	Signal transducer and activator of transcription.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.431
A0A1L8EKE2	ins-2	A0A1L8EKE2	B7ZQP1	Signal transducer and activator of transcription.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.431
A0A1L8EKE2	jak2	A0A1L8EKE2	A0A1L8HY58	Signal transducer and activator of transcription.	Tyrosine-protein kinase.	0.988
A0A1L8EKE2	lep	A0A1L8EKE2	A0A1L8GZQ3	Signal transducer and activator of transcription.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.569
A0A1L8EKE2	lep-2	A0A1L8EKE2	Q563I5	Signal transducer and activator of transcription.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.569
A0A1L8EKE2	lif	A0A1L8EKE2	A0A1L8HZU9	Signal transducer and activator of transcription.	Uncharacterized protein.	0.448
A0A1L8EKE2	ptpn11b	A0A1L8EKE2	Q6GP31	Signal transducer and activator of transcription.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.471
A0A1L8EKE2	socs3	A0A1L8EKE2	Q6NU49	Signal transducer and activator of transcription.	MGC81248 protein.	0.518
A0A1L8EKE2	socs3l	A0A1L8EKE2	A0A1L8FH19	Signal transducer and activator of transcription.	Uncharacterized protein.	0.450
A0A1L8EKE2	src	A0A1L8EKE2	Q2TAR1	Signal transducer and activator of transcription.	Tyrosine-protein kinase.	0.600
A0A1L8EPW6	A0A1L8FND6	A0A1L8EPW6	A0A1L8FND6	Signal transducer and activator of transcription.	Uncharacterized protein.	0.513
A0A1L8EPW6	A0A1L8H9R9	A0A1L8EPW6	A0A1L8H9R9	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.510
A0A1L8EPW6	Jak2.S	A0A1L8EPW6	A0A310U8T2	Signal transducer and activator of transcription.	Tyrosine-protein kinase.	0.979