110 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	hes5.8-2	BHLH domain-containing protein. (140 aa)
	hes3-2	Uncharacterized protein. (204 aa)
	hes5.5	Uncharacterized protein. (158 aa)
	Hes2.L	BHLH domain-containing protein. (191 aa)
	bcl9l	BCL9 domain-containing protein. (1281 aa)
	Foxr1.L	Uncharacterized protein. (451 aa)
	mfrp	Uncharacterized protein. (590 aa)
	fgfr2-2	Fibroblast growth factor receptor. (832 aa)
	fgf20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	hes5.2-2	Enhancer of split related protein-7. (158 aa)
	hes5.3-2	Enhancer of split related 2. (183 aa)
	flt1	Vegf-B-prov protein. (687 aa)
	hes5.6-2	Enhancer of split related 9. (156 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	rhou	Rac-2 protein. (243 aa)
	gipc2	GIPC protein. (331 aa)
	hes5.2	Enhancer of split related protein 3/7b. (159 aa)
	hes5.7-2	Enhancer of split related protein 9b. (154 aa)
	src	Tyrosine-protein kinase. (532 aa)
	vegfa	Vascular endothelial growth factor 196; Belongs to the PDGF/VEGF growth factor family. (194 aa)
	wnt7b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	F8RUB0_XENLA	Secretin. (143 aa)
	xfz8	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	wnt10a-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	fz3	Fz3 protein; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa)
	fzd10a	Frizzled 10A; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
	hes5.5-2	Uncharacterized protein. (158 aa)
	fgf10-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
	wnt6-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	fgf10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	kdm4c-2	Uncharacterized protein. (1064 aa)
	ano8	Anoctamin. (1071 aa)
	Fgfr3.L	Fibroblast growth factor receptor. (821 aa)
	fzd10	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
	kdm4c	Uncharacterized protein. (1140 aa)
	gipc3	PDZ domain-containing protein. (338 aa)
	kdr	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1326 aa)
	wnt10b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
	Wnt1.L	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (830 aa)
	vangl1-2	Vang-like protein. (499 aa)
	Fzd4.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
	Flt1.S	Uncharacterized protein. (683 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	vangl1	Vang-like protein. (503 aa)
	fgfr1-2	Fibroblast growth factor receptor. (812 aa)
	Smo.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (815 aa)
	ano6	Anoctamin. (909 aa)
	fgfr4	Fibroblast growth factor receptor. (807 aa)
	Fgfr4.S	Fibroblast growth factor receptor. (825 aa)
	prickle1	Uncharacterized protein. (835 aa)
	pik3cg	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1115 aa)
	Smo.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (814 aa)
	fgfr1	Fibroblast growth factor receptor. (810 aa)
	Wnt5b.S	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (375 aa)
	prickle2-2	Uncharacterized protein. (833 aa)
	Opsin	Rhodopsin. (403 aa)
	Rho.L	Rhodopsin. (459 aa)
	nkd1	EF-hand domain-containing protein. (453 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	Fgf4.L	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
	prickle2	Uncharacterized protein. (833 aa)
	A0A1L8GHL0	Rhodopsin. (354 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
	Ano1.L	Anoctamin. (976 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (237 aa)
	sox17b.1-2	Uncharacterized protein. (373 aa)
	fzd6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (724 aa)
	Esr1.S	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	pik3cb	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	fzd3	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa)
	hes5.3	Uncharacterized protein. (164 aa)
	hes5.8	Uncharacterized protein. (149 aa)
	hes5.6	BHLH domain-containing protein. (156 aa)
	hes5.9	BHLH domain-containing protein. (155 aa)
	hes5.7	BHLH domain-containing protein. (155 aa)
	hes5.4-2	Uncharacterized protein. (159 aa)
	hes3	BHLH domain-containing protein. (204 aa)
	fgfr2	Fibroblast growth factor receptor. (830 aa)
	dact1	Uncharacterized protein. (824 aa)
	jmjd1c	JmjC domain-containing protein. (2324 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	notch1	Uncharacterized protein. (2521 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	crb2	Uncharacterized protein. (1472 aa)
	Notch1.S	Uncharacterized protein. (2524 aa)
	Dact1.S	Uncharacterized protein. (818 aa)
	fzd7	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (549 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	wnt9b.2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	Fmnl1.L	Uncharacterized protein. (1158 aa)
	asxl1	Uncharacterized protein. (951 aa)
	fzd5	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
	wnt10a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	hes5.4	Hairy and enhancer of split 5. (159 aa)
	ncoa1-2	Nuclear receptor coactivator. (1497 aa)
	pik3cb-2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	ncoa1	Nuclear receptor coactivator. (1488 aa)
	egfr-2	Receptor protein-tyrosine kinase. (1210 aa)
	fzd1	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa)
	Fzd8.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	Shh.L	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (444 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	Wnt9a.S	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (528 aa)
	Fzd6.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (715 aa)
	Sox17a.S	Uncharacterized protein. (377 aa)
	sox17b.1	Uncharacterized protein. (373 aa)
	asxl3	Uncharacterized protein. (2140 aa)
	egfr	Receptor protein-tyrosine kinase. (1208 aa)
	hes5.9-2	BHLH domain-containing protein. (155 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8GHL0	F8RUB0_XENLA	A0A1L8GHL0	F8RUB0	Rhodopsin.	Secretin.	0.621
A0A1L8GHL0	Opsin	A0A1L8GHL0	A0A1L8GPM0	Rhodopsin.	Rhodopsin.	0.900
A0A1L8GHL0	Rho.L	A0A1L8GHL0	A0A1L8GPJ9	Rhodopsin.	Rhodopsin.	0.901
A0A1L8GHL0	Shh.L	A0A1L8GHL0	A0A1L8FV87	Rhodopsin.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.428
A0A1L8GHL0	Smo.L	A0A1L8GHL0	A0A1L8GZN4	Rhodopsin.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.666
A0A1L8GHL0	Smo.S	A0A1L8GHL0	A0A1L8GTP2	Rhodopsin.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.689
Ano1.L	ano8	A0A1L8GDR4	A0A1L8HXF4	Anoctamin.	Anoctamin.	0.448
Dact1.S	nkd1	A0A1L8EZZ3	A0A1L8GKG8	Uncharacterized protein.	EF-hand domain-containing protein.	0.597
Dact1.S	prickle1	A0A1L8EZZ3	A0A1L8GUA2	Uncharacterized protein.	Uncharacterized protein.	0.551
Dact1.S	prickle2	A0A1L8EZZ3	A0A1L8GI20	Uncharacterized protein.	Uncharacterized protein.	0.410
Dact1.S	prickle2-2	A0A1L8EZZ3	A0A1L8GQ36	Uncharacterized protein.	Uncharacterized protein.	0.410
Dact1.S	vangl1	A0A1L8EZZ3	A0A1L8H5Y3	Uncharacterized protein.	Vang-like protein.	0.610
Dact1.S	vangl1-2	A0A1L8EZZ3	A0A1L8HBP1	Uncharacterized protein.	Vang-like protein.	0.608
Esr1.S	Notch1.S	A0A1L8G265	A0A1L8F124	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Uncharacterized protein.	0.508
Esr1.S	egfr	A0A1L8G265	A0A1L8FRS8	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Receptor protein-tyrosine kinase.	0.839
Esr1.S	egfr-2	A0A1L8G265	A0A1L8FWP8	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Receptor protein-tyrosine kinase.	0.839
Esr1.S	kdm1a	A0A1L8G265	A0A1L8HFM2	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.880
Esr1.S	kdm4c	A0A1L8G265	A0A1L8HP44	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Uncharacterized protein.	0.537
Esr1.S	kdm4c-2	A0A1L8G265	A0A1L8HY51	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Uncharacterized protein.	0.537
Esr1.S	ncoa1	A0A1L8G265	A0A1L8G5Q8	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator.	0.877