STRINGSTRING
tbx5-2 tbx5-2 Sox2.S Sox2.S A0A1L8ELB6 A0A1L8ELB6 foxj1 foxj1 gli2 gli2 sh3bp4 sh3bp4 Fn1.S Fn1.S Axin1.S Axin1.S Foxj1.L Foxj1.L gli2-2 gli2-2 sh3bp4-2 sh3bp4-2 fzd7 fzd7 foxj1.2 foxj1.2 foxg1 foxg1 Notch1.S Notch1.S tgfb1 tgfb1 vangl2 vangl2 taz taz notch1 notch1 wnt11b wnt11b tgfb1-2 tgfb1-2 Nkx2-1.L Nkx2-1.L vangl2-2 vangl2-2 tagln2 tagln2 fgfr2 fgfr2 hhex hhex dkk1 dkk1 fgfr2-2 fgfr2-2 hhex-2 hhex-2 A0A1L8FQM4 A0A1L8FQM4 egfr egfr Fzd6.S Fzd6.S Aqp1.L Aqp1.L Shh.L Shh.L Fzd8.L Fzd8.L fzd1 fzd1 etv4 etv4 egfr-2 egfr-2 sfrp4 sfrp4 snai2 snai2 fzd6 fzd6 bmp2 bmp2 Lats1.S Lats1.S pik3cb pik3cb Mycn.S Mycn.S id2 id2 fzd3 fzd3 Bmp2.L Bmp2.L pik3cb-2 pik3cb-2 Id2.L Id2.L fgf4 fgf4 Dkk3.S Dkk3.S Cdh3.S Cdh3.S Fgf4.L Fgf4.L cdh1 cdh1 cdh3 cdh3 Rho.L Rho.L A0A1L8GQT6 A0A1L8GQT6 fgfr1 fgfr1 A0A1L8GRM4 A0A1L8GRM4 Sftpc.S Sftpc.S sfrp1 sfrp1 map2k1 map2k1 fgf7 fgf7 pik3cg pik3cg foxp2 foxp2 fgf1 fgf1 fgf1-2 fgf1-2 foxp2-2 foxp2-2 Sfrp1.L Sfrp1.L fgfr1-2 fgfr1-2 A0A1L8H2E9 A0A1L8H2E9 gli1 gli1 Pdx1.S Pdx1.S Fzd4.S Fzd4.S hdac1 hdac1 tbx4 tbx4 Gli1.L Gli1.L pdx1 pdx1 Yap1.L Yap1.L wnt11 wnt11 lef1 lef1 dkk2 dkk2 tbx5 tbx5 fzd10 fzd10 apc apc sfrp2 sfrp2 spry1 spry1 Pitx2.S Pitx2.S Tcf3.L Tcf3.L apc-2 apc-2 fgf10 fgf10 mycn mycn fgf10-2 fgf10-2 spry1-2 spry1-2 nog nog fgf9-A fgf9-A fzd10a fzd10a fz3 fz3 xfz8 xfz8 grem1 grem1 Tbx1 Tbx1 LOC100189571 LOC100189571 sox9-a sox9-a wnt7b wnt7b dkk1-2 dkk1-2 cdh11-2 cdh11-2 src src fgf7-2 fgf7-2 pax9 pax9 ctnnb1 ctnnb1 pitx2 pitx2 tagln2-2 tagln2-2 sfrp2-2 sfrp2-2 actl6a actl6a hdac1-2 hdac1-2 fgf8 fgf8 snai2-2 snai2-2 lef1-2 lef1-2 bmp4-2 bmp4-2 dkk2-2 dkk2-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tbx5-2T-box transcription factor Tbx5. (519 aa)
Sox2.SHMG box domain-containing protein. (194 aa)
A0A1L8ELB6Uncharacterized protein. (261 aa)
foxj1Fork-head domain-containing protein. (439 aa)
gli2Uncharacterized protein. (1468 aa)
sh3bp4Uncharacterized protein. (957 aa)
Fn1.SUncharacterized protein. (2480 aa)
Axin1.SUncharacterized protein. (839 aa)
Foxj1.LFork-head domain-containing protein. (495 aa)
gli2-2Uncharacterized protein. (1475 aa)
sh3bp4-2Uncharacterized protein. (957 aa)
fzd7Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (549 aa)
foxj1.2Fork-head domain-containing protein. (402 aa)
foxg1Fork-head domain-containing protein. (418 aa)
Notch1.SUncharacterized protein. (2524 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
vangl2Vang-like protein. (521 aa)
tazTafazzin family protein; Belongs to the taffazin family. (262 aa)
notch1Uncharacterized protein. (2521 aa)
wnt11bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
tgfb1-2Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
Nkx2-1.LHomeobox domain-containing protein. (347 aa)
vangl2-2Vang-like protein. (521 aa)
tagln2Transgelin; Belongs to the calponin family. (197 aa)
fgfr2Fibroblast growth factor receptor. (830 aa)
hhexHomeobox domain-containing protein. (276 aa)
dkk1Dickkopf_N domain-containing protein. (263 aa)
fgfr2-2Fibroblast growth factor receptor. (832 aa)
hhex-2Homeobox domain-containing protein. (272 aa)
A0A1L8FQM4Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (429 aa)
egfrReceptor protein-tyrosine kinase. (1208 aa)
Fzd6.SUncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (715 aa)
Aqp1.LUncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (274 aa)
Shh.LHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (444 aa)
Fzd8.LUncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
fzd1Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa)
etv4ETS domain-containing protein. (477 aa)
egfr-2Receptor protein-tyrosine kinase. (1210 aa)
sfrp4Uncharacterized protein. (353 aa)
snai2Uncharacterized protein. (266 aa)
fzd6Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (724 aa)
bmp2TGF_BETA_2 domain-containing protein. (398 aa)
Lats1.SUncharacterized protein. (1118 aa)
pik3cbUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
Mycn.SBHLH domain-containing protein. (439 aa)
id2BHLH domain-containing protein. (135 aa)
fzd3Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa)
Bmp2.LTGF_BETA_2 domain-containing protein. (398 aa)
pik3cb-2Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
Id2.LBHLH domain-containing protein. (133 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
Dkk3.SDickkopf_N domain-containing protein. (257 aa)
Cdh3.SUncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (880 aa)
Fgf4.LFibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
cdh1Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (871 aa)
cdh3Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
Rho.LRhodopsin. (459 aa)
A0A1L8GQT6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
fgfr1Fibroblast growth factor receptor. (810 aa)
A0A1L8GRM4Uncharacterized protein. (2165 aa)
Sftpc.SBRICHOS domain-containing protein. (298 aa)
sfrp1Uncharacterized protein. (311 aa)
map2k1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)
fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
pik3cgUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1115 aa)
foxp2Fork-head domain-containing protein. (740 aa)
fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (156 aa)
fgf1-2Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
foxp2-2Fork-head domain-containing protein. (736 aa)
Sfrp1.LUncharacterized protein. (311 aa)
fgfr1-2Fibroblast growth factor receptor. (812 aa)
A0A1L8H2E9Uncharacterized protein. (2404 aa)
gli1Uncharacterized protein. (1361 aa)
Pdx1.SHomeobox domain-containing protein. (271 aa)
Fzd4.SUncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
hdac1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
tbx4Uncharacterized protein. (541 aa)
Gli1.LUncharacterized protein. (1362 aa)
pdx1Homeobox domain-containing protein. (271 aa)
Yap1.LUncharacterized protein. (459 aa)
wnt11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
lef1HMG box domain-containing protein. (372 aa)
dkk2Dickkopf_N domain-containing protein. (255 aa)
tbx5Uncharacterized protein. (519 aa)
fzd10Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
apcUncharacterized protein. (2827 aa)
sfrp2Uncharacterized protein. (295 aa)
spry1Uncharacterized protein. (342 aa)
Pitx2.SHomeobox protein. (326 aa)
Tcf3.LBHLH domain-containing protein. (709 aa)
apc-2Uncharacterized protein. (2834 aa)
fgf10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
mycnBHLH domain-containing protein. (437 aa)
fgf10-2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
spry1-2Sprouty 1. (319 aa)
nogNoggin; Belongs to the noggin family. (222 aa)
fgf9-AFibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
fzd10aFrizzled 10A; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
fz3Fz3 protein; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa)
xfz8Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
grem1Gremlin. (182 aa)
Tbx1T-box transcription factor. (463 aa)
LOC100189571Uncharacterized protein. (608 aa)
sox9-aSex determining region Y-box 9. (477 aa)
wnt7bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
dkk1-2Dickkopf homolog 1. (259 aa)
cdh11-2Cadherin; Cadherins are calcium-dependent cell adhesion proteins. (794 aa)
srcTyrosine-protein kinase. (532 aa)
fgf7-2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
pax9Paired box transcription factor. (360 aa)
ctnnb1Beta-catenin protein. (781 aa)
pitx2Homeobox protein. (323 aa)
tagln2-2Transgelin; Belongs to the calponin family. (197 aa)
sfrp2-2Sfrp2-prov protein. (298 aa)
actl6aBaf53a-pending-prov protein; Belongs to the actin family. (429 aa)
hdac1-2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
snai2-2Zinc finger transcription factor slug beta. (266 aa)
lef1-2Lymphoid enhancer factor XLEF-1. (372 aa)
bmp4-2Bone morphogenetic protein 4. (400 aa)
dkk2-2Dickkopf homolog 2. (255 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
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