(12 nodes) (2015) A distinct mechanism of vascular lumen formation in Xenopus requires EGFL7. network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cldn5-2	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa)
	cdh5-2	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (775 aa)
	Tjp1.S	Uncharacterized protein; Belongs to the MAGUK family. (1705 aa)
	kdr	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1326 aa)
	Alb.S	Uncharacterized protein. (607 aa)
	LOC100189571	Uncharacterized protein. (608 aa)
	cldn5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa)
	actl6a	Baf53a-pending-prov protein; Belongs to the actin family. (429 aa)
	Fn1.S	Uncharacterized protein. (2480 aa)
	Notch1.S	Uncharacterized protein. (2524 aa)
	notch1	Uncharacterized protein. (2521 aa)
	cdh5	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (774 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Alb.S	Fn1.S	A0A1L8HMG9	A0A1L8EPN8	Uncharacterized protein.	Uncharacterized protein.	0.698
Alb.S	Tjp1.S	A0A1L8HMG9	A0A1L8H090	Uncharacterized protein.	Uncharacterized protein; Belongs to the MAGUK family.	0.474
Alb.S	actl6a	A0A1L8HMG9	Q7ZYI5	Uncharacterized protein.	Baf53a-pending-prov protein; Belongs to the actin family.	0.882
Fn1.S	Alb.S	A0A1L8EPN8	A0A1L8HMG9	Uncharacterized protein.	Uncharacterized protein.	0.698
Fn1.S	LOC100189571	A0A1L8EPN8	B7ZRX0	Uncharacterized protein.	Uncharacterized protein.	0.698
Fn1.S	Notch1.S	A0A1L8EPN8	A0A1L8F124	Uncharacterized protein.	Uncharacterized protein.	0.568
Fn1.S	Tjp1.S	A0A1L8EPN8	A0A1L8H090	Uncharacterized protein.	Uncharacterized protein; Belongs to the MAGUK family.	0.498
Fn1.S	actl6a	A0A1L8EPN8	Q7ZYI5	Uncharacterized protein.	Baf53a-pending-prov protein; Belongs to the actin family.	0.893
Fn1.S	cdh5	A0A1L8EPN8	A0A1L8GEW5	Uncharacterized protein.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.482
Fn1.S	cdh5-2	A0A1L8EPN8	A0A1L8GKR1	Uncharacterized protein.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.482
Fn1.S	notch1	A0A1L8EPN8	A0A1L8F627	Uncharacterized protein.	Uncharacterized protein.	0.564
LOC100189571	Fn1.S	B7ZRX0	A0A1L8EPN8	Uncharacterized protein.	Uncharacterized protein.	0.698
LOC100189571	Notch1.S	B7ZRX0	A0A1L8F124	Uncharacterized protein.	Uncharacterized protein.	0.441
LOC100189571	Tjp1.S	B7ZRX0	A0A1L8H090	Uncharacterized protein.	Uncharacterized protein; Belongs to the MAGUK family.	0.550
LOC100189571	actl6a	B7ZRX0	Q7ZYI5	Uncharacterized protein.	Baf53a-pending-prov protein; Belongs to the actin family.	0.883
LOC100189571	cdh5	B7ZRX0	A0A1L8GEW5	Uncharacterized protein.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.428
LOC100189571	cdh5-2	B7ZRX0	A0A1L8GKR1	Uncharacterized protein.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.428
LOC100189571	cldn5	B7ZRX0	Q6GNW1	Uncharacterized protein.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.519
LOC100189571	cldn5-2	B7ZRX0	Q6PA22	Uncharacterized protein.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.519
LOC100189571	notch1	B7ZRX0	A0A1L8F627	Uncharacterized protein.	Uncharacterized protein.	0.438