23 items (Xenopus laevis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	hltf	Uncharacterized protein. (1000 aa)
	usp1	Ubiquitin carboxyl-terminal hydrolase. (766 aa)
	A0A1L8GS29	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (268 aa)
	rev1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1230 aa)
	mdm2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (489 aa)
	trib1	Protein kinase domain-containing protein. (367 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (540 aa)
	dtl	WD_REPEATS_REGION domain-containing protein. (710 aa)
	Dtl.L	WD_REPEATS_REGION domain-containing protein. (711 aa)
	RNF8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (532 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	ubl3	Ubiquitin-like protein. (117 aa)
	polh	Polh-prov protein. (684 aa)
	mapk15	Mitogen-activated protein kinase 15; Atypical MAPK protein that regulates ciliogenesis by phosphorylating rcsd1 through its binding with dvl2. (586 aa)
	esco1	Eco1. (967 aa)
	A0A1L8HPJ8	Ubiquitin-like domain-containing protein. (125 aa)
	rev1-2	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1237 aa)
	sumo2	Small ubiquitin-related modifier. (95 aa)
	Sumo1.S	Ubiquitin-like domain-containing protein. (141 aa)
	usp7	Uncharacterized protein; Belongs to the peptidase C19 family. (1123 aa)
	atad5	AAA domain-containing protein. (1740 aa)
	Sumo1.L	Ubiquitin-like domain-containing protein. (148 aa)
	usp7-2	Usp7; Belongs to the peptidase C19 family. (1124 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8GS29	A0A1L8HPJ8	A0A1L8GS29	A0A1L8HPJ8	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Ubiquitin-like domain-containing protein.	0.609
A0A1L8GS29	Dtl.L	A0A1L8GS29	A0A1L8G665	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	WD_REPEATS_REGION domain-containing protein.	0.965
A0A1L8GS29	Sumo1.L	A0A1L8GS29	A0A1L8EWZ5	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Ubiquitin-like domain-containing protein.	0.911
A0A1L8GS29	Sumo1.S	A0A1L8GS29	A0A1L8EPQ0	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Ubiquitin-like domain-containing protein.	0.911
A0A1L8GS29	atad5	A0A1L8GS29	A0A1L8EV17	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	AAA domain-containing protein.	0.968
A0A1L8GS29	dtl	A0A1L8GS29	A0A1L8G1C0	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	WD_REPEATS_REGION domain-containing protein.	0.965
A0A1L8GS29	esco1	A0A1L8GS29	E5LEW8	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Eco1.	0.785
A0A1L8GS29	hltf	A0A1L8GS29	A0A1L8GAS3	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.983
A0A1L8GS29	polh	A0A1L8GS29	Q6DCL9	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Polh-prov protein.	0.993
A0A1L8GS29	rev1	A0A1L8GS29	A0A1L8H8Q0	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.974
A0A1L8GS29	rev1-2	A0A1L8GS29	A0A1L8HGZ7	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.974
A0A1L8GS29	sumo2	A0A1L8GS29	A0A1L8EMU2	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Small ubiquitin-related modifier.	0.918
A0A1L8GS29	usp1	A0A1L8GS29	A0A1L8GF26	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Ubiquitin carboxyl-terminal hydrolase.	0.850
A0A1L8HPJ8	A0A1L8GS29	A0A1L8HPJ8	A0A1L8GS29	Ubiquitin-like domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.609
A0A1L8HPJ8	Dtl.L	A0A1L8HPJ8	A0A1L8G665	Ubiquitin-like domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.845
A0A1L8HPJ8	RNF8	A0A1L8HPJ8	A0A1L8G6W1	Ubiquitin-like domain-containing protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.637
A0A1L8HPJ8	Sumo1.L	A0A1L8HPJ8	A0A1L8EWZ5	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.924
A0A1L8HPJ8	Sumo1.S	A0A1L8HPJ8	A0A1L8EPQ0	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.924
A0A1L8HPJ8	dtl	A0A1L8HPJ8	A0A1L8G1C0	Ubiquitin-like domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.845
A0A1L8HPJ8	mdm2	A0A1L8HPJ8	A0A1L8GYI7	Ubiquitin-like domain-containing protein.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.564