57 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ddb1	CPSF_A domain-containing protein. (1140 aa)
	rps6ka3	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (737 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	Hus1	Checkpoint protein; Belongs to the HUS1 family. (282 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
	top2a	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1579 aa)
	fbxo6	LOC495428 protein. (253 aa)
	Clspn.S	Claspin. (1286 aa)
	PIK3R1	Phosphoinositide-3-kinase. (722 aa)
	Rad17.L	Uncharacterized protein. (674 aa)
	cdc45	Uncharacterized protein. (567 aa)
	primpol	Uncharacterized protein. (675 aa)
	brca2	Tower domain-containing protein. (3177 aa)
	nabp2-2	OB domain-containing protein. (203 aa)
	rev1-2	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1237 aa)
	ywhag-2	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa)
	cdkn1a	Uncharacterized protein. (261 aa)
	Cdk2.S	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
	nabp2	OB domain-containing protein. (203 aa)
	cul4a	CULLIN_2 domain-containing protein; Belongs to the cullin family. (753 aa)
	rev1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1230 aa)
	ywhag	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	skp1-2	Uncharacterized protein; Belongs to the SKP1 family. (221 aa)
	Cdc25c1	Rhodanese domain-containing protein. (550 aa)
	ticrr	Treslin_N domain-containing protein. (1968 aa)
	A0A1L8GS29	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (268 aa)
	skp1	Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
	Mcm2.L	DNA helicase; Belongs to the MCM family. (886 aa)
	Rad26	Uncharacterized protein. (798 aa)
	Ccnb1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (397 aa)
	ccne1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (408 aa)
	cdh3	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
	cdh1	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (871 aa)
	mus81	ERCC4 domain-containing protein. (613 aa)
	mcm2	DNA helicase; Belongs to the MCM family. (885 aa)
	atrip	Uncharacterized protein. (801 aa)
	Ccne1.S	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (408 aa)
	Plk1.S	Serine/threonine-protein kinase PLK. (598 aa)
	Dbf4b.L	DBF4-type domain-containing protein. (784 aa)
	plk1	Serine/threonine-protein kinase PLK. (598 aa)
	slx4	BTB domain-containing protein. (1773 aa)
	Endog.L	Endonuclease. (290 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa)
	cdk1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
	chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
	trim28	Uncharacterized protein. (798 aa)
	Cdk1.L	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (333 aa)
	chek1-2	Protein kinase domain-containing protein. (510 aa)
	A0A1L8FRI6	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1695 aa)
	dbf4	Uncharacterized protein. (661 aa)
	top2b	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1696 aa)
	topbp1	Uncharacterized protein. (1573 aa)
	dtl	WD_REPEATS_REGION domain-containing protein. (710 aa)
	Dtl.L	WD_REPEATS_REGION domain-containing protein. (711 aa)
	Cdc25a.S	Rhodanese domain-containing protein. (172 aa)
	Cdh1.S	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (914 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FRI6	A0A1L8GS29	A0A1L8FRI6	A0A1L8GS29	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.728
A0A1L8FRI6	Ccnb1	A0A1L8FRI6	A0A1L8GMA9	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.542
A0A1L8FRI6	Cdk1.L	A0A1L8FRI6	A0A1L8FIT4	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.795
A0A1L8FRI6	Cdk2.S	A0A1L8FRI6	A0A1L8H9N1	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.499
A0A1L8FRI6	Clspn.S	A0A1L8FRI6	F8WKR8	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	Claspin.	0.438
A0A1L8FRI6	Dbf4b.L	A0A1L8FRI6	A0A1L8ESD2	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	DBF4-type domain-containing protein.	0.486
A0A1L8FRI6	Mcm2.L	A0A1L8FRI6	A0A1L8GPN4	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	DNA helicase; Belongs to the MCM family.	0.540
A0A1L8FRI6	Plk1.S	A0A1L8FRI6	A0A1L8EQN7	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	Serine/threonine-protein kinase PLK.	0.593
A0A1L8FRI6	Rad17.L	A0A1L8FRI6	A0A1L8I1Y0	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	Uncharacterized protein.	0.421
A0A1L8FRI6	cdc45	A0A1L8FRI6	A0A1L8I0M4	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	Uncharacterized protein.	0.692
A0A1L8FRI6	cdk1	A0A1L8FRI6	A0A1L8FE96	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.795
A0A1L8FRI6	chek1	A0A1L8FRI6	A0A1L8FFS1	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.540
A0A1L8FRI6	chek1-2	A0A1L8FRI6	A0A1L8FL95	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	Protein kinase domain-containing protein.	0.539
A0A1L8FRI6	dbf4	A0A1L8FRI6	A0A1L8FVR6	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	Uncharacterized protein.	0.506
A0A1L8FRI6	mcm2	A0A1L8FRI6	A0A1L8GHP1	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	DNA helicase; Belongs to the MCM family.	0.540
A0A1L8FRI6	mus81	A0A1L8FRI6	A0A1L8GJY4	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	ERCC4 domain-containing protein.	0.502
A0A1L8FRI6	pcna	A0A1L8FRI6	Q9I893	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.728
A0A1L8FRI6	plk1	A0A1L8FRI6	A0A1L8EYC7	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	Serine/threonine-protein kinase PLK.	0.653
A0A1L8FRI6	rad51	A0A1L8FRI6	A0A1L8FB28	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.588
A0A1L8FRI6	ticrr	A0A1L8FRI6	A0A1L8GSL4	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	Treslin_N domain-containing protein.	0.569