36 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Egf.L	Uncharacterized protein. (1031 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	Sfrp5.S	Uncharacterized protein. (315 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	sfrp4	Uncharacterized protein. (353 aa)
	bmp2	TGF_BETA_2 domain-containing protein. (398 aa)
	Esr1.S	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	Bmp2.L	TGF_BETA_2 domain-containing protein. (398 aa)
	ryk	Uncharacterized protein. (596 aa)
	Lgr4.S	G_PROTEIN_RECEP_F1_2 domain-containing protein. (956 aa)
	Dkk3.S	Dickkopf_N domain-containing protein. (257 aa)
	lgr4	G_PROTEIN_RECEP_F1_2 domain-containing protein. (953 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	sfrp1	Uncharacterized protein. (311 aa)
	Furin.S	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (783 aa)
	wif1	Uncharacterized protein. (374 aa)
	Sfrp1.L	Uncharacterized protein. (311 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	dkk2	Dickkopf_N domain-containing protein. (255 aa)
	ror2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
	Kremen1.S	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (452 aa)
	sfrp2	Uncharacterized protein. (295 aa)
	lrg1	LRRCT domain-containing protein. (362 aa)
	kremen1	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (450 aa)
	tnf-2	Tumor necrosis factor alpha. (225 aa)
	wif1-2	Wnt inhibitory factor-1. (374 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	furin	LOC398345 protein; Belongs to the peptidase S8 family. (785 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	rhou	Rac-2 protein. (243 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	rhoa	MGC64296 protein. (193 aa)
	sfrp2-2	Sfrp2-prov protein. (298 aa)
	ror2-2	Receptor tyrosine kinase Xror2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
	sfrp5	Secreted frizzled-related protein 5. (315 aa)
	dkk2-2	Dickkopf homolog 2. (255 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Axin1.S	Bmp2.L	A0A1L8ER48	A0A1L8G5P4	Uncharacterized protein.	TGF_BETA_2 domain-containing protein.	0.458
Axin1.S	Dkk3.S	A0A1L8ER48	A0A1L8GDZ7	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.570
Axin1.S	Egf.L	A0A1L8ER48	A0A1L8HUT3	Uncharacterized protein.	Uncharacterized protein.	0.479
Axin1.S	Lgr4.S	A0A1L8ER48	A0A1L8GDQ5	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.597
Axin1.S	Lrp5.L	A0A1L8ER48	A0A1L8GJX4	Uncharacterized protein.	Uncharacterized protein.	0.998
Axin1.S	Sfrp1.L	A0A1L8ER48	A0A1L8H1S5	Uncharacterized protein.	Uncharacterized protein.	0.753
Axin1.S	Sfrp5.S	A0A1L8ER48	A0A1L8FEX3	Uncharacterized protein.	Uncharacterized protein.	0.571
Axin1.S	Tp53.L	A0A1L8ER48	A0A1L8H4M6	Uncharacterized protein.	P53 domain-containing protein.	0.679
Axin1.S	bmp2	A0A1L8ER48	A0A1L8G1N2	Uncharacterized protein.	TGF_BETA_2 domain-containing protein.	0.458
Axin1.S	ctnnb1	A0A1L8ER48	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.999
Axin1.S	dkk1	A0A1L8ER48	A0A1L8FIS6	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.890
Axin1.S	dkk1-2	A0A1L8ER48	O57464	Uncharacterized protein.	Dickkopf homolog 1.	0.892
Axin1.S	dkk2	A0A1L8ER48	A0A1L8HM80	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.712
Axin1.S	dkk2-2	A0A1L8ER48	Q9DDA4	Uncharacterized protein.	Dickkopf homolog 2.	0.711
Axin1.S	lgr4	A0A1L8ER48	A0A1L8GJ26	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.597
Axin1.S	rhoa	A0A1L8ER48	Q7SZA9	Uncharacterized protein.	MGC64296 protein.	0.551
Axin1.S	ror2	A0A1L8ER48	A0A1L8HPI6	Uncharacterized protein.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.612
Axin1.S	ror2-2	A0A1L8ER48	Q8AV69	Uncharacterized protein.	Receptor tyrosine kinase Xror2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.612
Axin1.S	ryk	A0A1L8ER48	A0A1L8GB75	Uncharacterized protein.	Uncharacterized protein.	0.696
Axin1.S	sfrp1	A0A1L8ER48	A0A1L8GRT5	Uncharacterized protein.	Uncharacterized protein.	0.739