9 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	Gapdh.S	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	kremen1	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (450 aa)
	Kremen1.S	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (452 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Gapdh.S	dkk1	Q7ZY52	A0A1L8FIS6	Glyceraldehyde-3-phosphate dehydrogenase.	Dickkopf_N domain-containing protein.	0.555
Gapdh.S	dkk1-2	Q7ZY52	O57464	Glyceraldehyde-3-phosphate dehydrogenase.	Dickkopf homolog 1.	0.559
Gapdh.S	gapdh	Q7ZY52	Q8AY70	Glyceraldehyde-3-phosphate dehydrogenase.	Glyceraldehyde-3-phosphate dehydrogenase.	0.900
Kremen1.S	Lrp5.L	A0A1L8HQW5	A0A1L8GJX4	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	Uncharacterized protein.	0.971
Kremen1.S	dkk1	A0A1L8HQW5	A0A1L8FIS6	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	Dickkopf_N domain-containing protein.	0.997
Kremen1.S	dkk1-2	A0A1L8HQW5	O57464	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	Dickkopf homolog 1.	0.998
Lrp5.L	Kremen1.S	A0A1L8GJX4	A0A1L8HQW5	Uncharacterized protein.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.971
Lrp5.L	dkk1	A0A1L8GJX4	A0A1L8FIS6	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.999
Lrp5.L	dkk1-2	A0A1L8GJX4	O57464	Uncharacterized protein.	Dickkopf homolog 1.	0.999
Lrp5.L	kremen1	A0A1L8GJX4	A0A1L8I1A4	Uncharacterized protein.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.971
dkk1	Gapdh.S	A0A1L8FIS6	Q7ZY52	Dickkopf_N domain-containing protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.555
dkk1	Kremen1.S	A0A1L8FIS6	A0A1L8HQW5	Dickkopf_N domain-containing protein.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.997
dkk1	Lrp5.L	A0A1L8FIS6	A0A1L8GJX4	Dickkopf_N domain-containing protein.	Uncharacterized protein.	0.999
dkk1	gapdh	A0A1L8FIS6	Q8AY70	Dickkopf_N domain-containing protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.556
dkk1	kremen1	A0A1L8FIS6	A0A1L8I1A4	Dickkopf_N domain-containing protein.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.997
dkk1-2	Gapdh.S	O57464	Q7ZY52	Dickkopf homolog 1.	Glyceraldehyde-3-phosphate dehydrogenase.	0.559
dkk1-2	Kremen1.S	O57464	A0A1L8HQW5	Dickkopf homolog 1.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.998
dkk1-2	Lrp5.L	O57464	A0A1L8GJX4	Dickkopf homolog 1.	Uncharacterized protein.	0.999
dkk1-2	gapdh	O57464	Q8AY70	Dickkopf homolog 1.	Glyceraldehyde-3-phosphate dehydrogenase.	0.559
dkk1-2	kremen1	O57464	A0A1L8I1A4	Dickkopf homolog 1.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.998