(13 nodes) (2016) Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasis. network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	stk24	Protein kinase domain-containing protein. (425 aa)
	oxsr1	Stk39 protein. (528 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	stk24-2	MGC80614 protein. (424 aa)
	mbp-2	Golli protein J37.1. (306 aa)
	wnk4	Protein kinase domain-containing protein. (1573 aa)
	wnk4-2	Protein kinase domain-containing protein. (1575 aa)
	Wnk3.S	Protein kinase domain-containing protein. (2749 aa)
	mbp	Uncharacterized protein. (308 aa)
	osr1	Uncharacterized protein. (259 aa)
	osr1-2	Uncharacterized protein. (259 aa)
	Wnk1.S	Uncharacterized protein. (265 aa)
	Ren.S	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (366 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ren.S	Wnk1.S	A0A1L8H6R4	A0A1L8GQQ4	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Uncharacterized protein.	0.720
Ren.S	Wnk3.S	A0A1L8H6R4	A0A1L8F1U7	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Protein kinase domain-containing protein.	0.479
Ren.S	oxsr1	A0A1L8H6R4	A0JPG0	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Stk39 protein.	0.830
Ren.S	wnk4	A0A1L8H6R4	A0A1L8EMC7	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Protein kinase domain-containing protein.	0.766
Ren.S	wnk4-2	A0A1L8H6R4	A0A1L8ETQ6	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Protein kinase domain-containing protein.	0.766
Wnk1.S	Ren.S	A0A1L8GQQ4	A0A1L8H6R4	Uncharacterized protein.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.720
Wnk1.S	Wnk3.S	A0A1L8GQQ4	A0A1L8F1U7	Uncharacterized protein.	Protein kinase domain-containing protein.	0.693
Wnk1.S	osr1	A0A1L8GQQ4	A0A1L8G5J9	Uncharacterized protein.	Uncharacterized protein.	0.832
Wnk1.S	osr1-2	A0A1L8GQQ4	A0A1L8GBX6	Uncharacterized protein.	Uncharacterized protein.	0.832
Wnk1.S	oxsr1	A0A1L8GQQ4	A0JPG0	Uncharacterized protein.	Stk39 protein.	0.978
Wnk1.S	stk24	A0A1L8GQQ4	A0A1L8H969	Uncharacterized protein.	Protein kinase domain-containing protein.	0.931
Wnk1.S	stk24-2	A0A1L8GQQ4	Q6GP83	Uncharacterized protein.	MGC80614 protein.	0.931
Wnk3.S	Ren.S	A0A1L8F1U7	A0A1L8H6R4	Protein kinase domain-containing protein.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.479
Wnk3.S	Wnk1.S	A0A1L8F1U7	A0A1L8GQQ4	Protein kinase domain-containing protein.	Uncharacterized protein.	0.693
Wnk3.S	osr1	A0A1L8F1U7	A0A1L8G5J9	Protein kinase domain-containing protein.	Uncharacterized protein.	0.833
Wnk3.S	osr1-2	A0A1L8F1U7	A0A1L8GBX6	Protein kinase domain-containing protein.	Uncharacterized protein.	0.832
Wnk3.S	oxsr1	A0A1L8F1U7	A0JPG0	Protein kinase domain-containing protein.	Stk39 protein.	0.712
Wnk3.S	wnk4	A0A1L8F1U7	A0A1L8EMC7	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.642
Wnk3.S	wnk4-2	A0A1L8F1U7	A0A1L8ETQ6	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.639
osr1	Wnk1.S	A0A1L8G5J9	A0A1L8GQQ4	Uncharacterized protein.	Uncharacterized protein.	0.832