104 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	lin28b	CCHC-type domain-containing protein. (253 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	hmga2-2	MGC81571 protein. (105 aa)
	axin2-2	MGC81576 protein. (707 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	hoxb7-2	Hoxb7 protein. (221 aa)
	gata3	XGATA-3 protein. (435 aa)
	sfrpx	LOC100125663 protein. (288 aa)
	hmga2	LOC100158391 protein. (105 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	sox9-a	Sex determining region Y-box 9. (477 aa)
	XMam1	XMam1 protein. (1039 aa)
	wif1-2	Wnt inhibitory factor-1. (374 aa)
	lin28a	RNA-binding protein LIN-28A. (195 aa)
	twist1-2	LOC100036981 protein. (166 aa)
	pten	Phosphatase and tensin homolog S homeolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
	Hist2h2ab.S	Histone H2A; Belongs to the histone H2A family. (139 aa)
	Plcg1.S	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1260 aa)
	znrf3	RING-type domain-containing protein. (854 aa)
	Aldh1a1.L	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (468 aa)
	ptpn13	Uncharacterized protein. (2502 aa)
	A0A1L8HUL3	Uncharacterized protein. (668 aa)
	sfrp2	Uncharacterized protein. (295 aa)
	Kit.L	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
	Proml-1	Uncharacterized protein. (890 aa)
	Znrf3.S	RING-type domain-containing protein. (848 aa)
	Ncor2.S	Uncharacterized protein. (2420 aa)
	A0A1L8HLU1	MamL-1 domain-containing protein. (1090 aa)
	Kit.S	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (963 aa)
	A0A1L8HJN4	Uncharacterized protein. (291 aa)
	maml2-2	MamL-1 domain-containing protein. (995 aa)
	Ncor1.L	Uncharacterized protein. (2518 aa)
	maml2	MamL-1 domain-containing protein. (994 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	Gata3.L	Uncharacterized protein. (454 aa)
	foxp2-2	Fork-head domain-containing protein. (736 aa)
	mdm2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (489 aa)
	wif1	Uncharacterized protein. (374 aa)
	foxp2	Fork-head domain-containing protein. (740 aa)
	Smad3	Mothers against decapentaplegic homolog. (425 aa)
	Cdkn1b.S	Uncharacterized protein. (152 aa)
	cdh3	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
	cdh1	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (871 aa)
	Cfl1.L	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (292 aa)
	Cdh3.S	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (880 aa)
	cfl1	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (168 aa)
	A0A1L8G7I3	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (153 aa)
	bcl2l11-2	Uncharacterized protein. (194 aa)
	Jag1.L	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1214 aa)
	foxo3	Fork-head domain-containing protein. (656 aa)
	Esr1.S	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (721 aa)
	bcl2l11	Uncharacterized protein. (194 aa)
	jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1206 aa)
	fzd6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (724 aa)
	snai2	Uncharacterized protein. (266 aa)
	ezh2	Uncharacterized protein. (748 aa)
	Bmi1.L	RING-type domain-containing protein. (323 aa)
	Myc.S	Myc_N domain-containing protein. (176 aa)
	Fzd6.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (715 aa)
	Bcl2.S	BH4_2 domain-containing protein. (253 aa)
	twist1	BHLH domain-containing protein. (166 aa)
	Bmi1.S	RING-type domain-containing protein. (367 aa)
	axin2	Uncharacterized protein. (707 aa)
	prom1	Uncharacterized protein. (796 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	Setdb1.L	Uncharacterized protein. (1343 aa)
	cfl2	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (167 aa)
	numbl	PID domain-containing protein. (651 aa)
	jag2-2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1227 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	A0A1L8F8U7	PID domain-containing protein. (588 aa)
	pbx2	Homeobox domain-containing protein. (422 aa)
	ring1	RING-type domain-containing protein. (372 aa)
	notch1	Uncharacterized protein. (2521 aa)
	setdb1	Uncharacterized protein. (1290 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	NumbL	PID domain-containing protein. (588 aa)
	Notch1.S	Uncharacterized protein. (2524 aa)
	jag2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1223 aa)
	A0A1L8EZU6	PID domain-containing protein. (642 aa)
	Cfl2.S	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (310 aa)
	kremen2	Uncharacterized protein. (420 aa)
	Pdpk1.L	Protein kinase domain-containing protein. (528 aa)
	Cxcr4.L	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (450 aa)
	A0A1L8EUY4	Uncharacterized protein. (818 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1280 aa)
	sall4	Uncharacterized protein. (1063 aa)
	stat3.1	Signal transducer and activator of transcription. (769 aa)
	Kremen2.S	Uncharacterized protein. (421 aa)
	pdpk1	Protein kinase domain-containing protein. (507 aa)
	cxcr4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	Zeb2.S	Uncharacterized protein. (1246 aa)
	A0A1L8ENI4	Uncharacterized protein. (815 aa)
	hoxb7	Homeobox domain-containing protein. (220 aa)
	dll1-2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (721 aa)
	smad3	Mothers against decapentaplegic homolog. (425 aa)
	snai2-2	Zinc finger transcription factor slug beta. (266 aa)
	hras	Small G-protein H-Ras. (189 aa)
	ccnd1	Ccnd1-prov protein; Belongs to the cyclin family. (291 aa)
	actl6a	Baf53a-pending-prov protein; Belongs to the actin family. (429 aa)
	sfrp2-2	Sfrp2-prov protein. (298 aa)
	dstn	MGC53245 protein; Belongs to the actin-binding proteins ADF family. (153 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ENI4	Cdh3.S	A0A1L8ENI4	A0A1L8GET9	Uncharacterized protein.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.538
A0A1L8ENI4	Fzd6.S	A0A1L8ENI4	A0A1L8FTP5	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.566
A0A1L8ENI4	Jag1.L	A0A1L8ENI4	A0A1L8G723	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.440
A0A1L8ENI4	Myc.S	A0A1L8ENI4	A0A1L8FTW7	Uncharacterized protein.	Myc_N domain-containing protein.	0.692
A0A1L8ENI4	Notch1.S	A0A1L8ENI4	A0A1L8F124	Uncharacterized protein.	Uncharacterized protein.	0.558
A0A1L8ENI4	Tp53.L	A0A1L8ENI4	A0A1L8H4M6	Uncharacterized protein.	P53 domain-containing protein.	0.591
A0A1L8ENI4	Znrf3.S	A0A1L8ENI4	A0A1L8HQY2	Uncharacterized protein.	RING-type domain-containing protein.	0.623
A0A1L8ENI4	actl6a	A0A1L8ENI4	Q7ZYI5	Uncharacterized protein.	Baf53a-pending-prov protein; Belongs to the actin family.	0.429
A0A1L8ENI4	ccnd1	A0A1L8ENI4	Q8AVQ4	Uncharacterized protein.	Ccnd1-prov protein; Belongs to the cyclin family.	0.853
A0A1L8ENI4	cdh1	A0A1L8ENI4	A0A1L8GKV4	Uncharacterized protein.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.562
A0A1L8ENI4	cdh3	A0A1L8ENI4	A0A1L8GKW6	Uncharacterized protein.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.562
A0A1L8ENI4	ctnnb1	A0A1L8ENI4	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.998
A0A1L8ENI4	dkk1	A0A1L8ENI4	A0A1L8FIS6	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.899
A0A1L8ENI4	dkk1-2	A0A1L8ENI4	O57464	Uncharacterized protein.	Dickkopf homolog 1.	0.900
A0A1L8ENI4	fzd6	A0A1L8ENI4	A0A1L8FZR1	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.566
A0A1L8ENI4	jag1	A0A1L8ENI4	A0A1L8G0P5	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.440
A0A1L8ENI4	myc	A0A1L8ENI4	Q6NRN4	Uncharacterized protein.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.776
A0A1L8ENI4	notch1	A0A1L8ENI4	A0A1L8F627	Uncharacterized protein.	Uncharacterized protein.	0.558
A0A1L8ENI4	sfrp2	A0A1L8ENI4	A0A1L8HUI3	Uncharacterized protein.	Uncharacterized protein.	0.667
A0A1L8ENI4	sfrp2-2	A0A1L8ENI4	Q7ZXM6	Uncharacterized protein.	Sfrp2-prov protein.	0.667