STRINGSTRING
pten pten dusp4 dusp4 pdgfra-2 pdgfra-2 klb-2 klb-2 Fgfr3.L Fgfr3.L Dusp4.S Dusp4.S pdgfra pdgfra klb klb kl-2 kl-2 spry2 spry2 kl kl fgfr1-2 fgfr1-2 map2k1-2 map2k1-2 igf1r igf1r frs2 frs2 fgfr4 fgfr4 msx2-2 msx2-2 fgf1-2 fgf1-2 msx2 msx2 fgf1 fgf1 Fgfr4.S Fgfr4.S map2k1 map2k1 fgfr1 fgfr1 pdgfrb pdgfrb Runx2.L Runx2.L Esrp1.L Esrp1.L egfr-2 egfr-2 esrp1 esrp1 egfr egfr fgfr2-2 fgfr2-2 fgfr2 fgfr2 sh3bp4-2 sh3bp4-2 grb14 grb14 grb2-2 grb2-2 stat3.1 stat3.1 sh3bp4 sh3bp4 grb2 grb2 spry2-2 spry2-2 Ptpn11.S Ptpn11.S ptpn11b ptpn11b frs3 frs3 crkl-2 crkl-2 crkl crkl stat5b stat5b fgf8 fgf8 src src mapk14 mapk14 LOC398022 LOC398022 LOC398006 LOC398006 fgf2-2 fgf2-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ptenPhosphatase and tensin homolog S homeolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
dusp4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (406 aa)
pdgfra-2Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1087 aa)
klb-2Uncharacterized protein. (1008 aa)
Fgfr3.LFibroblast growth factor receptor. (821 aa)
Dusp4.SDual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (385 aa)
pdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
klbUncharacterized protein. (1006 aa)
kl-2Uncharacterized protein. (984 aa)
spry2Uncharacterized protein. (307 aa)
klUncharacterized protein. (983 aa)
fgfr1-2Fibroblast growth factor receptor. (812 aa)
map2k1-2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)
igf1rTyrosine-protein kinase receptor. (1358 aa)
frs2IRS-type PTB domain-containing protein. (518 aa)
fgfr4Fibroblast growth factor receptor. (807 aa)
msx2-2Homeobox domain-containing protein. (257 aa)
fgf1-2Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
msx2Homeobox domain-containing protein. (257 aa)
fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (156 aa)
Fgfr4.SFibroblast growth factor receptor. (825 aa)
map2k1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)
fgfr1Fibroblast growth factor receptor. (810 aa)
pdgfrbUncharacterized protein. (1074 aa)
Runx2.LRunt-related transcription factor. (455 aa)
Esrp1.LUncharacterized protein. (688 aa)
egfr-2Receptor protein-tyrosine kinase. (1210 aa)
esrp1Uncharacterized protein. (687 aa)
egfrReceptor protein-tyrosine kinase. (1208 aa)
fgfr2-2Fibroblast growth factor receptor. (832 aa)
fgfr2Fibroblast growth factor receptor. (830 aa)
sh3bp4-2Uncharacterized protein. (957 aa)
grb14Uncharacterized protein. (451 aa)
grb2-2Uncharacterized protein. (229 aa)
stat3.1Signal transducer and activator of transcription. (769 aa)
sh3bp4Uncharacterized protein. (957 aa)
grb2Uncharacterized protein. (229 aa)
spry2-2LOC398313 protein. (314 aa)
Ptpn11.STyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
ptpn11bTyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
frs3Frs3 protein. (517 aa)
crkl-2MGC81407 protein. (302 aa)
crklMGC84382 protein. (302 aa)
stat5bSignal transducer and activator of transcription. (781 aa)
fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
srcTyrosine-protein kinase. (532 aa)
mapk14Mitogen-activated protein kinase. (361 aa)
LOC398022Tyrosine-protein kinase receptor. (1363 aa)
LOC398006Tyrosine-protein kinase receptor. (1362 aa)
fgf2-2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
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