47 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	sumo2	Small ubiquitin-related modifier. (95 aa)
	Plk1.S	Serine/threonine-protein kinase PLK. (598 aa)
	Eme1.L	ERCC4 domain-containing protein. (411 aa)
	sumo2-2	Ubiquitin-like domain-containing protein. (98 aa)
	plk1	Serine/threonine-protein kinase PLK. (598 aa)
	Exo1.S	Uncharacterized protein. (734 aa)
	fancf	Uncharacterized protein. (348 aa)
	Fancm.L	Uncharacterized protein. (2165 aa)
	cdk1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
	Dna2.S	Uncharacterized protein. (1053 aa)
	chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
	Dclre1a.L	DRMBL domain-containing protein. (932 aa)
	Cdk1.L	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (333 aa)
	ercc1	Uncharacterized protein. (297 aa)
	chek1-2	Protein kinase domain-containing protein. (510 aa)
	rbbp8	Uncharacterized protein. (846 aa)
	Rbbp8.L	Uncharacterized protein. (856 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (540 aa)
	Senp6.S	ULP_PROTEASE domain-containing protein. (1103 aa)
	RNF8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (532 aa)
	Fancl.L	RING-type domain-containing protein. (361 aa)
	usp1	Ubiquitin carboxyl-terminal hydrolase. (766 aa)
	atrip	Uncharacterized protein. (801 aa)
	mus81	ERCC4 domain-containing protein. (613 aa)
	faap24	Uncharacterized protein. (216 aa)
	Rad26	Uncharacterized protein. (798 aa)
	fancd2	Uncharacterized protein. (1445 aa)
	pias1	Uncharacterized protein. (640 aa)
	rad50	Zinc-hook domain-containing protein. (1311 aa)
	rad50-2	Zinc-hook domain-containing protein. (1312 aa)
	fan1	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1015 aa)
	fanci	Uncharacterized protein. (1337 aa)
	Pias1.L	Uncharacterized protein. (649 aa)
	Dnmt1.L	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1488 aa)
	ube2t	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (192 aa)
	brca2	Tower domain-containing protein. (3177 aa)
	Uhrf1.S	Uncharacterized protein. (397 aa)
	fancg	TPR_REGION domain-containing protein. (640 aa)
	Rnf4-a	RING-type domain-containing protein. (190 aa)
	Xpa.L	XPA_C domain-containing protein. (265 aa)
	fancc	Uncharacterized protein. (551 aa)
	Chek2.L	Uncharacterized protein. (392 aa)
	Rad17.L	Uncharacterized protein. (674 aa)
	Fanca.L	Fanconi_A_N domain-containing protein. (1423 aa)
	Clspn.S	Claspin. (1286 aa)
	rnf4	LOC495944 protein. (190 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cdk1.L	Chek2.L	A0A1L8FIT4	A0A1L8I0A0	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.597
Cdk1.L	Clspn.S	A0A1L8FIT4	F8WKR8	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Claspin.	0.818
Cdk1.L	Dna2.S	A0A1L8FIT4	A0A1L8FF41	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.642
Cdk1.L	Eme1.L	A0A1L8FIT4	A0A1L8EUA9	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	ERCC4 domain-containing protein.	0.601
Cdk1.L	Exo1.S	A0A1L8FIT4	A0A1L8F3G5	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.904
Cdk1.L	Plk1.S	A0A1L8FIT4	A0A1L8EQN7	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase PLK.	0.984
Cdk1.L	RNF8	A0A1L8FIT4	A0A1L8G6W1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.408
Cdk1.L	Rad26	A0A1L8FIT4	A0A1L8GP12	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.625
Cdk1.L	Rbbp8.L	A0A1L8FIT4	A0A1L8FYP2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.647
Cdk1.L	atrip	A0A1L8FIT4	A0A1L8GH95	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.625
Cdk1.L	brca2	A0A1L8FIT4	A0A1L8HIX3	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Tower domain-containing protein.	0.737
Cdk1.L	cdk1	A0A1L8FIT4	A0A1L8FE96	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.900
Cdk1.L	chek1	A0A1L8FIT4	A0A1L8FFS1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.859
Cdk1.L	chek1-2	A0A1L8FIT4	A0A1L8FL95	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.860
Cdk1.L	fancd2	A0A1L8FIT4	A0A1L8GP71	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.489
Cdk1.L	fanci	A0A1L8FIT4	A0A1L8H0X8	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.673
Cdk1.L	mus81	A0A1L8FIT4	A0A1L8GJY4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	ERCC4 domain-containing protein.	0.612
Cdk1.L	plk1	A0A1L8FIT4	A0A1L8EYC7	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase PLK.	0.984
Cdk1.L	rad50	A0A1L8FIT4	A0A1L8GVF0	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Zinc-hook domain-containing protein.	0.439
Cdk1.L	rad50-2	A0A1L8FIT4	A0A1L8GXM0	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Zinc-hook domain-containing protein.	0.439