STRINGSTRING
bambi-2 bambi-2 c-Jun c-Jun rac3 rac3 rnf43 rnf43 A0A1L8H5Z7 A0A1L8H5Z7 wnt1 wnt1 Fzd4.S Fzd4.S fzd9-2 fzd9-2 Wnt1.L Wnt1.L wnt11 wnt11 lef1 lef1 cks2 cks2 ror2 ror2 fzd10 fzd10 Kremen1.S Kremen1.S Znrf3.S Znrf3.S sfrp2 sfrp2 Egf.L Egf.L jak2 jak2 Nfil3 Nfil3 kremen1 kremen1 znrf3 znrf3 cks2-2 cks2-2 wif1-2 wif1-2 rspo2 rspo2 Xwnt-8b Xwnt-8b xfz8 xfz8 nlk nlk dkk1-2 dkk1-2 rac1 rac1 furin furin ctnnb1 ctnnb1 bambi bambi myc myc fzd9 fzd9 A0A1L8H5Q6 A0A1L8H5Q6 Tp53.L Tp53.L A0A1L8H482 A0A1L8H482 A0A1L8H2E9 A0A1L8H2E9 Sfrp1.L Sfrp1.L calml4-2 calml4-2 Prickle1.L Prickle1.L Lgr5.L Lgr5.L wif1 wif1 lgr5 lgr5 prickle1 prickle1 Furin.S Furin.S calml4 calml4 sfrp1 sfrp1 A0A1L8GRM4 A0A1L8GRM4 prickle2-2 prickle2-2 Jun.L Jun.L cdh3 cdh3 cdh1 cdh1 lgr4 lgr4 prickle2 prickle2 Cdh3.S Cdh3.S Dkk3.S Dkk3.S Lgr4.S Lgr4.S ryk ryk Irs1.S Irs1.S tp63-2 tp63-2 rspo3 rspo3 calm1 calm1 A0A1L8G4J8 A0A1L8G4J8 tp63 tp63 BOP1 BOP1 fzd6 fzd6 sfrp4 sfrp4 fzd1 fzd1 Fzd8.L Fzd8.L wnt3a wnt3a Fzd6.S Fzd6.S chek1-2 chek1-2 Sirt1.L Sirt1.L dkk1 dkk1 Errfi1.S Errfi1.S chek1 chek1 sirt1 sirt1 Spred1.L Spred1.L wnt11b wnt11b cited1 cited1 notch1 notch1 prickle3-b prickle3-b Notch1.S Notch1.S obp obp fzd7 fzd7 Frzb-1 Frzb-1 Sdc4.L Sdc4.L stat3.1 stat3.1 Axin1.S Axin1.S fzd5 fzd5 Frzb.S Frzb.S fzd2 fzd2 errfi1 errfi1 rhoa rhoa sfrp2-2 sfrp2-2 ror2-2 ror2-2 creb1 creb1 hras hras lef1-2 lef1-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
bambi-2BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
c-JunC-Jun protein; Belongs to the bZIP family. (312 aa)
rac3RAC1 protein. (192 aa)
rnf43RING-type domain-containing protein. (664 aa)
A0A1L8H5Z7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (534 aa)
wnt1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
Fzd4.SUncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
fzd9-2Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (587 aa)
Wnt1.LProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
wnt11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
lef1HMG box domain-containing protein. (372 aa)
cks2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
ror2Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
fzd10Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
Kremen1.SKremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (452 aa)
Znrf3.SRING-type domain-containing protein. (848 aa)
sfrp2Uncharacterized protein. (295 aa)
Egf.LUncharacterized protein. (1031 aa)
jak2Tyrosine-protein kinase. (1129 aa)
Nfil3Nuclear factor interleukin-3-regulated protein; May act as a transcriptional regulator of a number of proteins of the circadian clock; Belongs to the bZIP family. NFIL3 subfamily. (456 aa)
kremen1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (450 aa)
znrf3RING-type domain-containing protein. (854 aa)
cks2-2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
wif1-2Wnt inhibitory factor-1. (374 aa)
rspo2R-spondin 2. (243 aa)
Xwnt-8bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (428 aa)
xfz8Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
nlkMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (533 aa)
dkk1-2Dickkopf homolog 1. (259 aa)
rac1MGC114731 protein. (192 aa)
furinLOC398345 protein; Belongs to the peptidase S8 family. (785 aa)
ctnnb1Beta-catenin protein. (781 aa)
bambiBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (261 aa)
mycTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
fzd9Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (587 aa)
A0A1L8H5Q6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
Tp53.LP53 domain-containing protein. (137 aa)
A0A1L8H482Uncharacterized protein. (814 aa)
A0A1L8H2E9Uncharacterized protein. (2404 aa)
Sfrp1.LUncharacterized protein. (311 aa)
calml4-2Uncharacterized protein. (152 aa)
Prickle1.LUncharacterized protein. (832 aa)
Lgr5.LG_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
wif1Uncharacterized protein. (374 aa)
lgr5G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
prickle1Uncharacterized protein. (835 aa)
Furin.SP/Homo B domain-containing protein; Belongs to the peptidase S8 family. (783 aa)
calml4Uncharacterized protein. (153 aa)
sfrp1Uncharacterized protein. (311 aa)
A0A1L8GRM4Uncharacterized protein. (2165 aa)
prickle2-2Uncharacterized protein. (833 aa)
Jun.LBZIP domain-containing protein; Belongs to the bZIP family. (314 aa)
cdh3Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
cdh1Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (871 aa)
lgr4G_PROTEIN_RECEP_F1_2 domain-containing protein. (953 aa)
prickle2Uncharacterized protein. (833 aa)
Cdh3.SUncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (880 aa)
Dkk3.SDickkopf_N domain-containing protein. (257 aa)
Lgr4.SG_PROTEIN_RECEP_F1_2 domain-containing protein. (956 aa)
rykUncharacterized protein. (596 aa)
Irs1.SUncharacterized protein. (1227 aa)
tp63-2Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (636 aa)
rspo3Uncharacterized protein. (253 aa)
calm1Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
A0A1L8G4J8Uncharacterized protein. (1123 aa)
tp63Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (637 aa)
BOP1Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (728 aa)
fzd6Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (724 aa)
sfrp4Uncharacterized protein. (353 aa)
fzd1Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa)
Fzd8.LUncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
Fzd6.SUncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (715 aa)
chek1-2Protein kinase domain-containing protein. (510 aa)
Sirt1.LDeacetylase sirtuin-type domain-containing protein. (722 aa)
dkk1Dickkopf_N domain-containing protein. (263 aa)
Errfi1.SInhibitor_Mig-6 domain-containing protein. (404 aa)
chek1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
sirt1Deacetylase sirtuin-type domain-containing protein. (722 aa)
Spred1.LUncharacterized protein. (405 aa)
wnt11bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
cited1Uncharacterized protein. (142 aa)
notch1Uncharacterized protein. (2521 aa)
prickle3-bPrickle planar cell polarity protein 3-B; Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules. Proteins of the core module include the proteins Frizzled (Fz), Disheveled (Dsh), Van Gogh (Vang), Prickle (Pk), Flamingo (Fmi, Celsr) and Diego (Dgo). The core module proteins develop subcellular asymmetry, accumulating in two groups on opposite sides of epithelial cells. D [...] (536 aa)
Notch1.SUncharacterized protein. (2524 aa)
obpLipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (178 aa)
fzd7Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (549 aa)
Frzb-1Uncharacterized protein. (319 aa)
Sdc4.LSyndecan domain-containing protein. (205 aa)
stat3.1Signal transducer and activator of transcription. (769 aa)
Axin1.SUncharacterized protein. (839 aa)
fzd5Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
Frzb.SUncharacterized protein. (319 aa)
fzd2Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
errfi1MGC68521 protein. (401 aa)
rhoaMGC64296 protein. (193 aa)
sfrp2-2Sfrp2-prov protein. (298 aa)
ror2-2Receptor tyrosine kinase Xror2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
creb1Creb1-prov protein. (324 aa)
hrasSmall G-protein H-Ras. (189 aa)
lef1-2Lymphoid enhancer factor XLEF-1. (372 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
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