(29 nodes) (2016) Cortical dynamics during cell motility are regulated by CRL3(KLHL21) E3 ubiquitin ligase. network (Xenopus laevis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ptk2.S	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1065 aa)
	klhl12	BTB domain-containing protein. (564 aa)
	klhl12-2	BTB domain-containing protein. (564 aa)
	A0A1L8HPJ8	Ubiquitin-like domain-containing protein. (125 aa)
	klhl22	BTB domain-containing protein. (625 aa)
	rbx1	RING-type domain-containing protein. (120 aa)
	itfg1	Uncharacterized protein. (601 aa)
	cul3-2	CULLIN_2 domain-containing protein; Belongs to the cullin family. (768 aa)
	gabpa	Uncharacterized protein. (454 aa)
	Clip1.S	Uncharacterized protein. (2319 aa)
	pxn	Uncharacterized protein; Belongs to the paxillin family. (542 aa)
	klhl22-2	BTB domain-containing protein. (671 aa)
	clip1	Uncharacterized protein. (2362 aa)
	gabpa-2	Gabpa-prov protein. (452 aa)
	actl6a	Baf53a-pending-prov protein; Belongs to the actin family. (429 aa)
	pxn-2	LOC397826 protein; Belongs to the paxillin family. (539 aa)
	Cops2.L	PCI domain-containing protein. (457 aa)
	Mapre2.S	Uncharacterized protein. (327 aa)
	Ptk2.L	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1097 aa)
	map4	Microtubule-associated protein. (1211 aa)
	klhl21	BTB domain-containing protein. (615 aa)
	plk1	Serine/threonine-protein kinase PLK. (598 aa)
	spop-2	Uncharacterized protein. (374 aa)
	Plk1.S	Serine/threonine-protein kinase PLK. (598 aa)
	Fn1.S	Uncharacterized protein. (2480 aa)
	spop	Uncharacterized protein. (374 aa)
	cul3	CULLIN_2 domain-containing protein; Belongs to the cullin family. (768 aa)
	mapre2	Uncharacterized protein. (326 aa)
	Map4.L	Microtubule-associated protein. (1234 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8HPJ8	Cops2.L	A0A1L8HPJ8	A0A1L8H0N4	Ubiquitin-like domain-containing protein.	PCI domain-containing protein.	0.892
A0A1L8HPJ8	Plk1.S	A0A1L8HPJ8	A0A1L8EQN7	Ubiquitin-like domain-containing protein.	Serine/threonine-protein kinase PLK.	0.470
A0A1L8HPJ8	cul3	A0A1L8HPJ8	A0A1L8G4G3	Ubiquitin-like domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.992
A0A1L8HPJ8	cul3-2	A0A1L8HPJ8	A0A1L8GAJ9	Ubiquitin-like domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.992
A0A1L8HPJ8	klhl12	A0A1L8HPJ8	A0A1L8H768	Ubiquitin-like domain-containing protein.	BTB domain-containing protein.	0.573
A0A1L8HPJ8	klhl12-2	A0A1L8HPJ8	A0A1L8HEP6	Ubiquitin-like domain-containing protein.	BTB domain-containing protein.	0.573
A0A1L8HPJ8	klhl21	A0A1L8HPJ8	A0A1L8FMM6	Ubiquitin-like domain-containing protein.	BTB domain-containing protein.	0.685
A0A1L8HPJ8	klhl22	A0A1L8HPJ8	A0A1L8HQB4	Ubiquitin-like domain-containing protein.	BTB domain-containing protein.	0.677
A0A1L8HPJ8	klhl22-2	A0A1L8HPJ8	A0A1L8I0N8	Ubiquitin-like domain-containing protein.	BTB domain-containing protein.	0.676
A0A1L8HPJ8	plk1	A0A1L8HPJ8	A0A1L8EYC7	Ubiquitin-like domain-containing protein.	Serine/threonine-protein kinase PLK.	0.463
A0A1L8HPJ8	rbx1	A0A1L8HPJ8	A0A1L8GGS6	Ubiquitin-like domain-containing protein.	RING-type domain-containing protein.	0.996
A0A1L8HPJ8	spop	A0A1L8HPJ8	A0A1L8EL48	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.631
A0A1L8HPJ8	spop-2	A0A1L8HPJ8	A0A1L8ES82	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.631
Clip1.S	Map4.L	A0A1L8HQN4	A0A1L8FUT9	Uncharacterized protein.	Microtubule-associated protein.	0.679
Clip1.S	Mapre2.S	A0A1L8HQN4	A0A1L8FSZ3	Uncharacterized protein.	Uncharacterized protein.	0.717
Clip1.S	Plk1.S	A0A1L8HQN4	A0A1L8EQN7	Uncharacterized protein.	Serine/threonine-protein kinase PLK.	0.809
Clip1.S	actl6a	A0A1L8HQN4	Q7ZYI5	Uncharacterized protein.	Baf53a-pending-prov protein; Belongs to the actin family.	0.718
Clip1.S	clip1	A0A1L8HQN4	A0A1L8I128	Uncharacterized protein.	Uncharacterized protein.	0.900
Clip1.S	itfg1	A0A1L8HQN4	A0A1L8GFF8	Uncharacterized protein.	Uncharacterized protein.	0.882
Clip1.S	map4	A0A1L8HQN4	A0A1L8FQC1	Uncharacterized protein.	Microtubule-associated protein.	0.682