25 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Rad26	Uncharacterized protein. (798 aa)
	rfwd3-2	RING-type domain-containing protein. (751 aa)
	atrip	Uncharacterized protein. (801 aa)
	rfwd3	RING-type domain-containing protein. (750 aa)
	Rbbp8.L	Uncharacterized protein. (856 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	Hus1	Checkpoint protein; Belongs to the HUS1 family. (282 aa)
	Brca1.L	Uncharacterized protein. (1582 aa)
	smarcal1	Uncharacterized protein; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (960 aa)
	palb2	PALB2_WD40 domain-containing protein. (1427 aa)
	top3a	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1022 aa)
	Dna2.S	Uncharacterized protein. (1053 aa)
	chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
	chek1-2	Protein kinase domain-containing protein. (510 aa)
	rbbp8	Uncharacterized protein. (846 aa)
	topbp1	Uncharacterized protein. (1573 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
	Rad17.L	Uncharacterized protein. (674 aa)
	Chek2.L	Uncharacterized protein. (392 aa)
	brca2	Tower domain-containing protein. (3177 aa)
	rpa2-2	RPA_C domain-containing protein. (276 aa)
	Rpa1.L	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (609 aa)
	rpa2	RPA_C domain-containing protein. (274 aa)
	rad50-2	Zinc-hook domain-containing protein. (1312 aa)
	rad50	Zinc-hook domain-containing protein. (1311 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Brca1.L	Chek2.L	A0A1L8ETS4	A0A1L8I0A0	Uncharacterized protein.	Uncharacterized protein.	0.992
Brca1.L	Dna2.S	A0A1L8ETS4	A0A1L8FF41	Uncharacterized protein.	Uncharacterized protein.	0.969
Brca1.L	Hus1	A0A1L8ETS4	Q8JHD8	Uncharacterized protein.	Checkpoint protein; Belongs to the HUS1 family.	0.885
Brca1.L	Rad17.L	A0A1L8ETS4	A0A1L8I1Y0	Uncharacterized protein.	Uncharacterized protein.	0.877
Brca1.L	Rad26	A0A1L8ETS4	A0A1L8GP12	Uncharacterized protein.	Uncharacterized protein.	0.959
Brca1.L	Rbbp8.L	A0A1L8ETS4	A0A1L8FYP2	Uncharacterized protein.	Uncharacterized protein.	0.999
Brca1.L	Rpa1.L	A0A1L8ETS4	A0A1L8HDB4	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.920
Brca1.L	atrip	A0A1L8ETS4	A0A1L8GH95	Uncharacterized protein.	Uncharacterized protein.	0.959
Brca1.L	brca2	A0A1L8ETS4	A0A1L8HIX3	Uncharacterized protein.	Tower domain-containing protein.	0.999
Brca1.L	chek1	A0A1L8ETS4	A0A1L8FFS1	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.980
Brca1.L	chek1-2	A0A1L8ETS4	A0A1L8FL95	Uncharacterized protein.	Protein kinase domain-containing protein.	0.980
Brca1.L	palb2	A0A1L8ETS4	A0A1L8EY82	Uncharacterized protein.	PALB2_WD40 domain-containing protein.	0.999
Brca1.L	pcna	A0A1L8ETS4	Q9I893	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.528
Brca1.L	rad50	A0A1L8ETS4	A0A1L8GVF0	Uncharacterized protein.	Zinc-hook domain-containing protein.	0.963
Brca1.L	rad50-2	A0A1L8ETS4	A0A1L8GXM0	Uncharacterized protein.	Zinc-hook domain-containing protein.	0.963
Brca1.L	rad9a	A0A1L8ETS4	Q7ZZU5	Uncharacterized protein.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.905
Brca1.L	rbbp8	A0A1L8ETS4	A0A1L8FSU5	Uncharacterized protein.	Uncharacterized protein.	0.999
Brca1.L	rpa2	A0A1L8ETS4	A0A1L8H7J6	Uncharacterized protein.	RPA_C domain-containing protein.	0.731
Brca1.L	rpa2-2	A0A1L8ETS4	A0A1L8HE73	Uncharacterized protein.	RPA_C domain-containing protein.	0.731
Brca1.L	smarcal1	A0A1L8ETS4	A0A1L8EVE4	Uncharacterized protein.	Uncharacterized protein; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	0.780