27 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rnf4	LOC495944 protein. (190 aa)
	ins-2	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	pten	Phosphatase and tensin homolog S homeolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
	Rnf4-a	RING-type domain-containing protein. (190 aa)
	Fanca.L	Fanconi_A_N domain-containing protein. (1423 aa)
	Hist2h2ab.S	Histone H2A; Belongs to the histone H2A family. (139 aa)
	pik3c3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (886 aa)
	Egf.L	Uncharacterized protein. (1031 aa)
	e2f1-2	LOC100036852 protein. (426 aa)
	brca2	Tower domain-containing protein. (3177 aa)
	ube2t	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (192 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	fanci	Uncharacterized protein. (1337 aa)
	fancd2	Uncharacterized protein. (1445 aa)
	usp1	Ubiquitin carboxyl-terminal hydrolase. (766 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	Prkdc.L	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (4146 aa)
	A0A1L8FND1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
	Fancm.L	Uncharacterized protein. (2165 aa)
	mdc1	Uncharacterized protein. (2103 aa)
	slx4	BTB domain-containing protein. (1773 aa)
	plk1	Serine/threonine-protein kinase PLK. (598 aa)
	palb2	PALB2_WD40 domain-containing protein. (1427 aa)
	Ercc4.L	ERCC4 domain-containing protein. (924 aa)
	Plk1.S	Serine/threonine-protein kinase PLK. (598 aa)
	sumo2	Small ubiquitin-related modifier. (95 aa)
	e2f1	E2F_TDP domain-containing protein. (427 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FND1	Egf.L	A0A1L8FND1	A0A1L8HUT3	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.962
A0A1L8FND1	Tp53.L	A0A1L8FND1	A0A1L8H4M6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	P53 domain-containing protein.	0.703
A0A1L8FND1	ins	A0A1L8FND1	A0A1L8GD41	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.907
A0A1L8FND1	ins-2	A0A1L8FND1	B7ZQP1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.905
A0A1L8FND1	pten	A0A1L8FND1	A1L2J3	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Phosphatase and tensin homolog S homeolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.691
Egf.L	A0A1L8FND1	A0A1L8HUT3	A0A1L8FND1	Uncharacterized protein.	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.962
Egf.L	Tp53.L	A0A1L8HUT3	A0A1L8H4M6	Uncharacterized protein.	P53 domain-containing protein.	0.659
Egf.L	ins	A0A1L8HUT3	A0A1L8GD41	Uncharacterized protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.961
Egf.L	ins-2	A0A1L8HUT3	B7ZQP1	Uncharacterized protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.961
Egf.L	pten	A0A1L8HUT3	A1L2J3	Uncharacterized protein.	Phosphatase and tensin homolog S homeolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.585
Ercc4.L	Fanca.L	A0A1L8EXJ6	A0A310UBA7	ERCC4 domain-containing protein.	Fanconi_A_N domain-containing protein.	0.944
Ercc4.L	Fancm.L	A0A1L8EXJ6	A0A1L8F9Q1	ERCC4 domain-containing protein.	Uncharacterized protein.	0.938
Ercc4.L	Plk1.S	A0A1L8EXJ6	A0A1L8EQN7	ERCC4 domain-containing protein.	Serine/threonine-protein kinase PLK.	0.526
Ercc4.L	brca2	A0A1L8EXJ6	A0A1L8HIX3	ERCC4 domain-containing protein.	Tower domain-containing protein.	0.824
Ercc4.L	fancd2	A0A1L8EXJ6	A0A1L8GP71	ERCC4 domain-containing protein.	Uncharacterized protein.	0.956
Ercc4.L	fanci	A0A1L8EXJ6	A0A1L8H0X8	ERCC4 domain-containing protein.	Uncharacterized protein.	0.937
Ercc4.L	mdc1	A0A1L8EXJ6	A0A1L8F8K7	ERCC4 domain-containing protein.	Uncharacterized protein.	0.634
Ercc4.L	palb2	A0A1L8EXJ6	A0A1L8EY82	ERCC4 domain-containing protein.	PALB2_WD40 domain-containing protein.	0.662
Ercc4.L	plk1	A0A1L8EXJ6	A0A1L8EYC7	ERCC4 domain-containing protein.	Serine/threonine-protein kinase PLK.	0.480
Ercc4.L	slx4	A0A1L8EXJ6	A0A1L8EYC9	ERCC4 domain-containing protein.	BTB domain-containing protein.	0.998