46 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	topbp1	Uncharacterized protein. (1573 aa)
	Plk1.S	Serine/threonine-protein kinase PLK. (598 aa)
	Cdc6.L	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (645 aa)
	Dbf4b.L	DBF4-type domain-containing protein. (784 aa)
	Eme1.L	ERCC4 domain-containing protein. (411 aa)
	smarcal1	Uncharacterized protein; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (960 aa)
	zranb3	Uncharacterized protein. (1110 aa)
	eme2	ERCC4 domain-containing protein. (500 aa)
	plk1	Serine/threonine-protein kinase PLK. (598 aa)
	slx4	BTB domain-containing protein. (1773 aa)
	Exo1.S	Uncharacterized protein. (734 aa)
	atrx	Uncharacterized protein. (2276 aa)
	Endog.L	Endonuclease. (290 aa)
	Fancm.L	Uncharacterized protein. (2165 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa)
	cdk1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
	Dna2.S	Uncharacterized protein. (1053 aa)
	Cdk1.L	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (333 aa)
	Cdc25a.S	Rhodanese domain-containing protein. (172 aa)
	dbf4	Uncharacterized protein. (661 aa)
	Atr.L	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2654 aa)
	hltf	Uncharacterized protein. (1000 aa)
	Ccne1.S	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (408 aa)
	atrip	Uncharacterized protein. (801 aa)
	mus81	ERCC4 domain-containing protein. (613 aa)
	ccne1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (408 aa)
	Rad26	Uncharacterized protein. (798 aa)
	fancd2	Uncharacterized protein. (1445 aa)
	A0A1L8GS29	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (268 aa)
	Tipin.S	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (361 aa)
	Cdc25c1	Rhodanese domain-containing protein. (550 aa)
	Recql.L	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (652 aa)
	tipin	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (362 aa)
	Mrc1.L	C-type lectin domain-containing protein. (220 aa)
	Ahcyl1.S	Adenosylhomocysteinase. (489 aa)
	Cdk2.S	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
	primpol	Uncharacterized protein. (675 aa)
	wrn	Uncharacterized protein. (1434 aa)
	Chek2.L	Uncharacterized protein. (392 aa)
	cdc45	Uncharacterized protein. (567 aa)
	Rad17.L	Uncharacterized protein. (674 aa)
	Clspn.S	Claspin. (1286 aa)
	slc25a20-2	Slc25a20-prov protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (301 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
	Hus1	Checkpoint protein; Belongs to the HUS1 family. (282 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8GS29	Atr.L	A0A1L8GS29	A0A1L8GAP7	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.743
A0A1L8GS29	Ccne1.S	A0A1L8GS29	A0A1L8GF58	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.561
A0A1L8GS29	Cdc6.L	A0A1L8GS29	A0A1L8ES00	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.585
A0A1L8GS29	Cdk1.L	A0A1L8GS29	A0A1L8FIT4	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.614
A0A1L8GS29	Cdk2.S	A0A1L8GS29	A0A1L8H9N1	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.614
A0A1L8GS29	Chek2.L	A0A1L8GS29	A0A1L8I0A0	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.491
A0A1L8GS29	Dna2.S	A0A1L8GS29	A0A1L8FF41	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.794
A0A1L8GS29	Exo1.S	A0A1L8GS29	A0A1L8F3G5	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.977
A0A1L8GS29	Fancm.L	A0A1L8GS29	A0A1L8F9Q1	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.981
A0A1L8GS29	Rad17.L	A0A1L8GS29	A0A1L8I1Y0	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.904
A0A1L8GS29	Tipin.S	A0A1L8GS29	A0A1L8GSF3	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.468
A0A1L8GS29	atrx	A0A1L8GS29	A0A1L8F729	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.523
A0A1L8GS29	ccne1	A0A1L8GS29	A0A1L8GL65	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.561
A0A1L8GS29	cdc45	A0A1L8GS29	A0A1L8I0M4	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.510
A0A1L8GS29	cdk1	A0A1L8GS29	A0A1L8FE96	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.614
A0A1L8GS29	hltf	A0A1L8GS29	A0A1L8GAS3	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.983
A0A1L8GS29	mus81	A0A1L8GS29	A0A1L8GJY4	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	ERCC4 domain-containing protein.	0.725
A0A1L8GS29	rad51	A0A1L8GS29	A0A1L8FB28	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.967
A0A1L8GS29	smarcal1	A0A1L8GS29	A0A1L8EVE4	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	0.693
A0A1L8GS29	tipin	A0A1L8GS29	A0A1L8H168	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.468