(22 nodes) (2017) CK1 in Developmental Signaling: Hedgehog and Wnt. network (Xenopus laevis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	Prkacb.S	Uncharacterized protein; Belongs to the protein kinase superfamily. (338 aa)
	spop	Uncharacterized protein. (374 aa)
	gli2	Uncharacterized protein. (1468 aa)
	ihh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (409 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	spop-2	Uncharacterized protein. (374 aa)
	gli2-2	Uncharacterized protein. (1475 aa)
	ihh-2	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (409 aa)
	A0A1L8FEJ7	Suppressor of fused homolog. (474 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	Shh.L	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (444 aa)
	cul3	CULLIN_2 domain-containing protein; Belongs to the cullin family. (768 aa)
	cul3-2	CULLIN_2 domain-containing protein; Belongs to the cullin family. (768 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (396 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	kif7	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1383 aa)
	Arrb2.L	Arrestin_C domain-containing protein. (446 aa)
	A0A1L8HHZ2	DUF4203 domain-containing protein. (359 aa)
	csnk1g2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (412 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	prkaca	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	csnk1e	Casein kinase I epsilon; Belongs to the protein kinase superfamily. (416 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FEJ7	Prkacb.S	A0A1L8FEJ7	A0A1L8GLU4	Suppressor of fused homolog.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.926
A0A1L8FEJ7	Shh.L	A0A1L8FEJ7	A0A1L8FV87	Suppressor of fused homolog.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.786
A0A1L8FEJ7	ctnnb1	A0A1L8FEJ7	Q63ZT4	Suppressor of fused homolog.	Beta-catenin protein.	0.444
A0A1L8FEJ7	cul3	A0A1L8FEJ7	A0A1L8G4G3	Suppressor of fused homolog.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.961
A0A1L8FEJ7	cul3-2	A0A1L8FEJ7	A0A1L8GAJ9	Suppressor of fused homolog.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.961
A0A1L8FEJ7	gli2	A0A1L8FEJ7	A0A1L8ENK6	Suppressor of fused homolog.	Uncharacterized protein.	0.998
A0A1L8FEJ7	gli2-2	A0A1L8FEJ7	A0A1L8EV94	Suppressor of fused homolog.	Uncharacterized protein.	0.984
A0A1L8FEJ7	ihh	A0A1L8FEJ7	A0A1L8ENV9	Suppressor of fused homolog.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.783
A0A1L8FEJ7	ihh-2	A0A1L8FEJ7	A0A1L8EVN4	Suppressor of fused homolog.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.783
A0A1L8FEJ7	kif7	A0A1L8FEJ7	A0A1L8H0X0	Suppressor of fused homolog.	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.938
A0A1L8FEJ7	prkaca	A0A1L8FEJ7	Q90WN3	Suppressor of fused homolog.	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.926
A0A1L8FEJ7	prkacb	A0A1L8FEJ7	A0A1L8GFG6	Suppressor of fused homolog.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.926
A0A1L8FEJ7	spop	A0A1L8FEJ7	A0A1L8EL48	Suppressor of fused homolog.	Uncharacterized protein.	0.933
A0A1L8FEJ7	spop-2	A0A1L8FEJ7	A0A1L8ES82	Suppressor of fused homolog.	Uncharacterized protein.	0.933
A0A1L8HHZ2	Lrp5.L	A0A1L8HHZ2	A0A1L8GJX4	DUF4203 domain-containing protein.	Uncharacterized protein.	0.483
A0A1L8HHZ2	csnk1g2	A0A1L8HHZ2	A0A1L8HWS0	DUF4203 domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.539
A0A1L8HHZ2	ctnnb1	A0A1L8HHZ2	Q63ZT4	DUF4203 domain-containing protein.	Beta-catenin protein.	0.433
Arrb2.L	Axin1.S	A0A1L8H368	A0A1L8ER48	Arrestin_C domain-containing protein.	Uncharacterized protein.	0.609
Arrb2.L	Prkacb.S	A0A1L8H368	A0A1L8GLU4	Arrestin_C domain-containing protein.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.547
Arrb2.L	ctnnb1	A0A1L8H368	Q63ZT4	Arrestin_C domain-containing protein.	Beta-catenin protein.	0.403