53 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	kras-3	LOC397771 protein. (186 aa)
	kras	Uncharacterized protein. (186 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	axin2	Uncharacterized protein. (707 aa)
	Bmi1.S	RING-type domain-containing protein. (367 aa)
	Myc.S	Myc_N domain-containing protein. (176 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	Bmi1.L	RING-type domain-containing protein. (323 aa)
	jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1206 aa)
	Jag1.L	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1214 aa)
	Lgr4.S	G_PROTEIN_RECEP_F1_2 domain-containing protein. (956 aa)
	lgr4	G_PROTEIN_RECEP_F1_2 domain-containing protein. (953 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	lgr5	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	wif1	Uncharacterized protein. (374 aa)
	Lgr5.L	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	rnf43	RING-type domain-containing protein. (664 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	Fzd4.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
	Wnt1.L	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	Yap1.L	Uncharacterized protein. (459 aa)
	A0A1L8HJF4	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (456 aa)
	A0A1L8HPW4	Uncharacterized protein. (216 aa)
	Znrf3.S	RING-type domain-containing protein. (848 aa)
	Tcf3.L	BHLH domain-containing protein. (709 aa)
	hopx	Homeobox domain-containing protein. (80 aa)
	lif	Uncharacterized protein. (216 aa)
	znrf3	RING-type domain-containing protein. (854 aa)
	pten	Phosphatase and tensin homolog S homeolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
	hoxa9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (261 aa)
	wif1-2	Wnt inhibitory factor-1. (374 aa)
	ccnd2	Cyclin D2; Belongs to the cyclin family. (291 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	krasl	Uncharacterized protein. (187 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	axin2-2	MGC81576 protein. (707 aa)
	kras-2	Uncharacterized protein. (187 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	ccnd1	Ccnd1-prov protein; Belongs to the cyclin family. (291 aa)
	hras	Small G-protein H-Ras. (189 aa)
	Sox2.S	HMG box domain-containing protein. (194 aa)
	A0A1L8ENI4	Uncharacterized protein. (815 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	A0A1L8EUY4	Uncharacterized protein. (818 aa)
	tsc1	Uncharacterized protein. (1104 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	taz	Tafazzin family protein; Belongs to the taffazin family. (262 aa)
	Pou5f3.1	POU domain protein. (445 aa)
	pou5f3.2	POU domain protein. (449 aa)
	tsc1-2	Uncharacterized protein. (1102 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	gsk3a	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (424 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ENI4	A0A1L8HJF4	A0A1L8ENI4	A0A1L8HJF4	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.457
A0A1L8ENI4	Fzd4.S	A0A1L8ENI4	A0A1L8HB90	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.665
A0A1L8ENI4	Jag1.L	A0A1L8ENI4	A0A1L8G723	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.440
A0A1L8ENI4	Lgr4.S	A0A1L8ENI4	A0A1L8GDQ5	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.599
A0A1L8ENI4	Lgr5.L	A0A1L8ENI4	A0A1L8GYN0	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.817
A0A1L8ENI4	Lrp5.L	A0A1L8ENI4	A0A1L8GJX4	Uncharacterized protein.	Uncharacterized protein.	0.928
A0A1L8ENI4	Myc.S	A0A1L8ENI4	A0A1L8FTW7	Uncharacterized protein.	Myc_N domain-containing protein.	0.692
A0A1L8ENI4	Sox2.S	A0A1L8ENI4	A0A1L8EK54	Uncharacterized protein.	HMG box domain-containing protein.	0.445
A0A1L8ENI4	Tp53.L	A0A1L8ENI4	A0A1L8H4M6	Uncharacterized protein.	P53 domain-containing protein.	0.591
A0A1L8ENI4	Wnt1.L	A0A1L8ENI4	A0A1L8HHR8	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.872
A0A1L8ENI4	Znrf3.S	A0A1L8ENI4	A0A1L8HQY2	Uncharacterized protein.	RING-type domain-containing protein.	0.623
A0A1L8ENI4	ccnd1	A0A1L8ENI4	Q8AVQ4	Uncharacterized protein.	Ccnd1-prov protein; Belongs to the cyclin family.	0.853
A0A1L8ENI4	ctnnb1	A0A1L8ENI4	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.998
A0A1L8ENI4	dkk1	A0A1L8ENI4	A0A1L8FIS6	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.899
A0A1L8ENI4	dkk1-2	A0A1L8ENI4	O57464	Uncharacterized protein.	Dickkopf homolog 1.	0.900
A0A1L8ENI4	gsk3a	A0A1L8ENI4	A0A1L8FGT4	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.825
A0A1L8ENI4	jag1	A0A1L8ENI4	A0A1L8G0P5	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.440
A0A1L8ENI4	lgr4	A0A1L8ENI4	A0A1L8GJ26	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.599
A0A1L8ENI4	lgr5	A0A1L8ENI4	A0A1L8GUF4	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.817
A0A1L8ENI4	myc	A0A1L8ENI4	Q6NRN4	Uncharacterized protein.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.776