STRINGSTRING
dot1l-2 dot1l-2 hoxb4 hoxb4 h3f3b h3f3b grb2 grb2 ikzf2 ikzf2 crebbp crebbp stat3.1 stat3.1 Ikzf3.L Ikzf3.L cbx8 cbx8 grb2-2 grb2-2 Sphk1.L Sphk1.L ikzf2-2 ikzf2-2 A0A1L8EY07 A0A1L8EY07 crebbp-2 crebbp-2 top3a top3a aff2 aff2 gata1 gata1 mcl1 mcl1 Aff2.L Aff2.L Mcl1.L Mcl1.L cd3e cd3e cd79a cd79a kras kras dntt dntt prom1 prom1 cd3e-2 cd3e-2 cd79a-2 cd79a-2 Bmi1.S Bmi1.S Bcl2.S Bcl2.S Myc.S Myc.S Bmi1.L Bmi1.L ikzf1 ikzf1 limd1 limd1 hist2h3c hist2h3c bcl2l11 bcl2l11 Myb.S Myb.S prdm1 prdm1 Bcl6.S Bcl6.S ptk2b ptk2b Clic6.L Clic6.L bcl2l11-2 bcl2l11-2 prdm1-2 prdm1-2 ptk2b-2 ptk2b-2 rag2 rag2 rag1 rag1 abl2 abl2 pbx1 pbx1 rag1-2 rag1-2 Men1.L Men1.L Abl2.L Abl2.L Faslg.L Faslg.L Etv6.S Etv6.S Ebf1 Ebf1 pdgfrb pdgfrb wnt16 wnt16 nr3c1 nr3c1 aff4 aff4 mdm2 mdm2 wnt16-2 wnt16-2 Gata3.L Gata3.L sin3a sin3a tyk2 tyk2 Tp53.L Tp53.L lck lck Cdk4.L Cdk4.L mx1 mx1 Runx1.L Runx1.L Ncor1.L Ncor1.L nras nras Lck.L Lck.L Kit.S Kit.S nr3c2 nr3c2 dot1l dot1l tek tek bcr bcr ptger4 ptger4 Tcf4.S Tcf4.S nsd2 nsd2 Proml-1 Proml-1 Kit.L Kit.L Tcf3.L Tcf3.L Pax5.L Pax5.L Jak3.L Jak3.L jak2 jak2 syk syk tra tra Bcr.L Bcr.L Top3b.L Top3b.L sh2b3 sh2b3 ptger4-2 ptger4-2 pik3c3 pik3c3 Cdk9.L Cdk9.L A0A310TTQ1 A0A310TTQ1 Cdk6.L Cdk6.L Nt5c2.L Nt5c2.L brd3 brd3 hoxa9 hoxa9 gata1a-A gata1a-A hmga2 hmga2 src src gata3 gata3 rabif rabif tbp tbp bcl6 bcl6 krasl krasl hmga2-2 hmga2-2 nr3c2-2 nr3c2-2 wdr5 wdr5 kras-2 kras-2 zap70 zap70 wdr5-2 wdr5-2 pik3r2 pik3r2 nr3c1-2 nr3c1-2 clic4 clic4 ptpn11b ptpn11b psip1 psip1 myc myc stat5b stat5b hras hras kras-3 kras-3 Ptpn11.S Ptpn11.S
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dot1l-2Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1396 aa)
hoxb4Homeobox domain-containing protein. (232 aa)
h3f3bHistone H3; Belongs to the histone H3 family. (136 aa)
grb2Uncharacterized protein. (229 aa)
ikzf2Uncharacterized protein. (585 aa)
crebbpUncharacterized protein. (2424 aa)
stat3.1Signal transducer and activator of transcription. (769 aa)
Ikzf3.LUncharacterized protein. (513 aa)
cbx8Uncharacterized protein. (302 aa)
grb2-2Uncharacterized protein. (229 aa)
Sphk1.LDAGKc domain-containing protein. (509 aa)
ikzf2-2Uncharacterized protein. (585 aa)
A0A1L8EY07Histone H3; Belongs to the histone H3 family. (120 aa)
crebbp-2Uncharacterized protein. (2453 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1022 aa)
aff2Uncharacterized protein. (1224 aa)
gata1Uncharacterized protein. (367 aa)
mcl1Uncharacterized protein. (277 aa)
Aff2.LUncharacterized protein. (1251 aa)
Mcl1.LUncharacterized protein. (277 aa)
cd3eIGc2 domain-containing protein. (182 aa)
cd79aIg-like domain-containing protein. (207 aa)
krasUncharacterized protein. (186 aa)
dnttDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (507 aa)
prom1Uncharacterized protein. (796 aa)
cd3e-2Uncharacterized protein. (179 aa)
cd79a-2Ig-like domain-containing protein. (228 aa)
Bmi1.SRING-type domain-containing protein. (367 aa)
Bcl2.SBH4_2 domain-containing protein. (253 aa)
Myc.SMyc_N domain-containing protein. (176 aa)
Bmi1.LRING-type domain-containing protein. (323 aa)
ikzf1Uncharacterized protein. (567 aa)
limd1Uncharacterized protein. (613 aa)
hist2h3cHistone H3; Belongs to the histone H3 family. (136 aa)
bcl2l11Uncharacterized protein. (194 aa)
Myb.SUncharacterized protein. (626 aa)
prdm1Uncharacterized protein. (780 aa)
Bcl6.SUncharacterized protein. (701 aa)
ptk2bUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1013 aa)
Clic6.LChloride intracellular channel protein; Belongs to the chloride channel CLIC family. (378 aa)
bcl2l11-2Uncharacterized protein. (194 aa)
prdm1-2Uncharacterized protein. (780 aa)
ptk2b-2Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1014 aa)
rag2RAG2_PHD domain-containing protein. (520 aa)
rag1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1045 aa)
abl2Tyrosine-protein kinase. (1102 aa)
pbx1Homeobox domain-containing protein. (454 aa)
rag1-2V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1045 aa)
Men1.LUncharacterized protein. (675 aa)
Abl2.LTyrosine-protein kinase. (1102 aa)
Faslg.LTNF_2 domain-containing protein. (248 aa)
Etv6.SUncharacterized protein. (406 aa)
Ebf1COE1_DBD domain-containing protein. (312 aa)
pdgfrbUncharacterized protein. (1074 aa)
wnt16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
nr3c1Uncharacterized protein. (761 aa)
aff4Uncharacterized protein. (1144 aa)
mdm2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (489 aa)
wnt16-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
Gata3.LUncharacterized protein. (454 aa)
sin3aHDAC_interact domain-containing protein. (1273 aa)
tyk2Tyrosine-protein kinase. (1179 aa)
Tp53.LP53 domain-containing protein. (137 aa)
lckTyrosine-protein kinase. (503 aa)
Cdk4.LProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (348 aa)
mx1Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (624 aa)
Runx1.LRunt-related transcription factor. (462 aa)
Ncor1.LUncharacterized protein. (2518 aa)
nrasUncharacterized protein. (189 aa)
Lck.LTyrosine-protein kinase. (502 aa)
Kit.SMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (963 aa)
nr3c2Uncharacterized protein. (981 aa)
dot1lHistone-lysine N-methyltransferase, H3 lysine-79 specific. (1396 aa)
tekUncharacterized protein. (1126 aa)
bcrUncharacterized protein. (1160 aa)
ptger4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (476 aa)
Tcf4.SBHLH domain-containing protein. (490 aa)
nsd2Uncharacterized protein. (1300 aa)
Proml-1Uncharacterized protein. (890 aa)
Kit.LMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
Tcf3.LBHLH domain-containing protein. (709 aa)
Pax5.LPaired domain-containing protein. (389 aa)
Jak3.LTyrosine-protein kinase. (1118 aa)
jak2Tyrosine-protein kinase. (1129 aa)
sykTyrosine-protein kinase. (605 aa)
traIg-like domain-containing protein. (121 aa)
Bcr.LUncharacterized protein. (1180 aa)
Top3b.LDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (824 aa)
sh2b3Uncharacterized protein. (618 aa)
ptger4-2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (475 aa)
pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (886 aa)
Cdk9.LProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (376 aa)
A0A310TTQ1Histone H3; Belongs to the histone H3 family. (136 aa)
Cdk6.LProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (319 aa)
Nt5c2.LUncharacterized protein. (583 aa)
brd3LOC100036838 protein. (783 aa)
hoxa9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (261 aa)
gata1a-AGATA binding factor-1. (359 aa)
hmga2LOC100158391 protein. (105 aa)
srcTyrosine-protein kinase. (532 aa)
gata3XGATA-3 protein. (435 aa)
rabifMGC115104 protein. (118 aa)
tbpLOC503680 protein. (296 aa)
bcl6LOC495412 protein. (701 aa)
kraslUncharacterized protein. (187 aa)
hmga2-2MGC81571 protein. (105 aa)
nr3c2-2Nr3c2 protein. (979 aa)
wdr5Wdr5-b-prov protein. (334 aa)
kras-2Uncharacterized protein. (187 aa)
zap70Tyrosine-protein kinase. (617 aa)
wdr5-2Wdr5-prov protein. (334 aa)
pik3r2Pik3r2-prov protein. (457 aa)
nr3c1-2XGR protein. (776 aa)
clic4MGC83873 protein. (252 aa)
ptpn11bTyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
psip1LOC398545 protein. (566 aa)
mycTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
stat5bSignal transducer and activator of transcription. (781 aa)
hrasSmall G-protein H-Ras. (189 aa)
kras-3LOC397771 protein. (186 aa)
Ptpn11.STyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
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