41 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	c-Jun	C-Jun protein; Belongs to the bZIP family. (312 aa)
	A0A1L8EKE2	Signal transducer and activator of transcription. (760 aa)
	A0A1L8EKH9	STAT_int domain-containing protein. (635 aa)
	grb2	Uncharacterized protein. (229 aa)
	Cyct.L	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (136 aa)
	srebf1	BHLH domain-containing protein. (1159 aa)
	rab5c	Uncharacterized protein. (215 aa)
	Stat3.2.L	Signal transducer and activator of transcription. (760 aa)
	stat3.1	Signal transducer and activator of transcription. (769 aa)
	grb2-2	Uncharacterized protein. (229 aa)
	cyct	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	akt2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (486 aa)
	A0A1L8FND1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
	cycs	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	Rab5a.L	Uncharacterized protein. (216 aa)
	A0A1L8FW52	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	A0A1L8G4J8	Uncharacterized protein. (1123 aa)
	Irs1.S	Uncharacterized protein. (1227 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	txn2	Thioredoxin domain-containing protein. (223 aa)
	Jun.L	BZIP domain-containing protein; Belongs to the bZIP family. (314 aa)
	Nrf1.S	Nrf1_DNA-bind domain-containing protein. (523 aa)
	nrf1	Nrf1_DNA-bind domain-containing protein. (523 aa)
	A0A1L8H482	Uncharacterized protein. (814 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	oxt	Uncharacterized protein; Belongs to the vasopressin/oxytocin family. (125 aa)
	A0A1L8HNW1	Thioredoxin domain-containing protein. (151 aa)
	oxt-2	Uncharacterized protein; Belongs to the vasopressin/oxytocin family. (125 aa)
	A0A1L8HTA9	Uncharacterized protein. (3120 aa)
	A0A1L8HXP2	Thioredoxin domain-containing protein. (150 aa)
	A0A1L8HY24	Thioredoxin domain-containing protein. (108 aa)
	LOC100037235	Thioredoxin; Belongs to the thioredoxin family. (105 aa)
	ins-2	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	src	Tyrosine-protein kinase. (532 aa)
	txn	LOC495354 protein. (105 aa)
	gnaq	Gnaq-A protein. (359 aa)
	ptpn11b	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	MGC80314	Thioredoxin; Belongs to the thioredoxin family. (105 aa)
	txn2-2	Txn2-prov protein. (170 aa)
	actl6a	Baf53a-pending-prov protein; Belongs to the actin family. (429 aa)
	Ptpn11.S	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EKE2	A0A1L8FND1	A0A1L8EKE2	A0A1L8FND1	Signal transducer and activator of transcription.	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.431
A0A1L8EKE2	Jun.L	A0A1L8EKE2	A0A1L8GLZ4	Signal transducer and activator of transcription.	BZIP domain-containing protein; Belongs to the bZIP family.	0.647
A0A1L8EKE2	Ptpn11.S	A0A1L8EKE2	Q92124	Signal transducer and activator of transcription.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.471
A0A1L8EKE2	Tp53.L	A0A1L8EKE2	A0A1L8H4M6	Signal transducer and activator of transcription.	P53 domain-containing protein.	0.528
A0A1L8EKE2	c-Jun	A0A1L8EKE2	Q9PVZ1	Signal transducer and activator of transcription.	C-Jun protein; Belongs to the bZIP family.	0.647
A0A1L8EKE2	ins	A0A1L8EKE2	A0A1L8GD41	Signal transducer and activator of transcription.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.431
A0A1L8EKE2	ins-2	A0A1L8EKE2	B7ZQP1	Signal transducer and activator of transcription.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.431
A0A1L8EKE2	ptpn11b	A0A1L8EKE2	Q6GP31	Signal transducer and activator of transcription.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.471
A0A1L8EKE2	src	A0A1L8EKE2	Q2TAR1	Signal transducer and activator of transcription.	Tyrosine-protein kinase.	0.600
A0A1L8EKH9	Jun.L	A0A1L8EKH9	A0A1L8GLZ4	STAT_int domain-containing protein.	BZIP domain-containing protein; Belongs to the bZIP family.	0.606
A0A1L8EKH9	Ptpn11.S	A0A1L8EKH9	Q92124	STAT_int domain-containing protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.610
A0A1L8EKH9	Tp53.L	A0A1L8EKH9	A0A1L8H4M6	STAT_int domain-containing protein.	P53 domain-containing protein.	0.706
A0A1L8EKH9	c-Jun	A0A1L8EKH9	Q9PVZ1	STAT_int domain-containing protein.	C-Jun protein; Belongs to the bZIP family.	0.606
A0A1L8EKH9	grb2	A0A1L8EKH9	A0A1L8EMZ6	STAT_int domain-containing protein.	Uncharacterized protein.	0.457
A0A1L8EKH9	grb2-2	A0A1L8EKH9	A0A1L8EUF2	STAT_int domain-containing protein.	Uncharacterized protein.	0.457
A0A1L8EKH9	ptpn11b	A0A1L8EKH9	Q6GP31	STAT_int domain-containing protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.610
A0A1L8EKH9	src	A0A1L8EKH9	Q2TAR1	STAT_int domain-containing protein.	Tyrosine-protein kinase.	0.746
A0A1L8FND1	A0A1L8EKE2	A0A1L8FND1	A0A1L8EKE2	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Signal transducer and activator of transcription.	0.431
A0A1L8FND1	A0A1L8FW52	A0A1L8FND1	A0A1L8FW52	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.583
A0A1L8FND1	A0A1L8G4J8	A0A1L8FND1	A0A1L8G4J8	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.961