STRINGSTRING
mx1 mx1 adipor1 adipor1 hdac1 hdac1 ccl4 ccl4 A0A1L8HH28 A0A1L8HH28 Tnfsf11.L Tnfsf11.L hdac7-2 hdac7-2 dgat2-2 dgat2-2 pdgfra pdgfra fgf2 fgf2 A0A1L8HTA9 A0A1L8HTA9 pdgfra-2 pdgfra-2 ulk1 ulk1 eif2ak2 eif2ak2 fos fos fgf2-2 fgf2-2 gata1a-A gata1a-A PIK3R1 PIK3R1 LOC100189571 LOC100189571 lep-2 lep-2 ube2c-2 ube2c-2 krasl krasl gsn-2 gsn-2 kras-2 kras-2 adipor2 adipor2 atf3-2 atf3-2 fos-2 fos-2 atf5.2 atf5.2 adipoq-2 adipoq-2 pik3r1 pik3r1 myc myc hif1a hif1a adipor1-2 adipor1-2 actl6a actl6a hdac1-2 hdac1-2 hras hras A0A1L8G8Y0 A0A1L8G8Y0 adipoq adipoq A0A1L8G2V6 A0A1L8G2V6 Tnfaip3.S Tnfaip3.S atf3 atf3 A0A1L8FW11 A0A1L8FW11 Scin.L Scin.L A0A1L8FVW9 A0A1L8FVW9 Myc.S Myc.S Bcl2.S Bcl2.S A0A1L8FR37 A0A1L8FR37 A0A1L8FQH6 A0A1L8FQH6 Apoa5.L Apoa5.L kras kras apoa5 apoa5 Txnip.L Txnip.L psen1 psen1 tgfb1-2 tgfb1-2 irs4 irs4 hspa5 hspa5 gsn gsn txnip txnip gata1 gata1 tgfb1 tgfb1 Irs4.S Irs4.S A0A1L8EZY9 A0A1L8EZY9 Hdac4.L Hdac4.L ube2c ube2c hdac5 hdac5 stat3.1 stat3.1 hdac4 hdac4 Hdac5.S Hdac5.S thibz thibz kras-3 kras-3 rps6ka3 rps6ka3 c-Jun c-Jun pax6 pax6 maf maf Hmox1.S Hmox1.S pax6-2 pax6-2 maf-2 maf-2 Jun.L Jun.L A0A1L8GM23 A0A1L8GM23 hmox1 hmox1 RTCB RTCB Hdac3.S Hdac3.S egr1 egr1 lep lep Tp53.L Tp53.L A0A1L8H929 A0A1L8H929 tnfsf11 tnfsf11 hdac7 hdac7 dgat2 dgat2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mx1Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (624 aa)
adipor1Uncharacterized protein. (401 aa)
hdac1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
ccl4C-C motif chemokine. (89 aa)
A0A1L8HH28Uncharacterized protein. (1011 aa)
Tnfsf11.LTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (290 aa)
hdac7-2Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (957 aa)
dgat2-2Uncharacterized protein. (361 aa)
pdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
A0A1L8HTA9Uncharacterized protein. (3120 aa)
pdgfra-2Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1087 aa)
ulk1Protein kinase domain-containing protein. (1049 aa)
eif2ak2Double stranded RNA activated protein kinase 1. (578 aa)
fosBZIP domain-containing protein. (369 aa)
fgf2-2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
gata1a-AGATA binding factor-1. (359 aa)
PIK3R1Phosphoinositide-3-kinase. (722 aa)
LOC100189571Uncharacterized protein. (608 aa)
lep-2Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
ube2c-2LOC496302 protein; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
kraslUncharacterized protein. (187 aa)
gsn-2LOC397895 protein. (729 aa)
kras-2Uncharacterized protein. (187 aa)
adipor2MGC85478 protein. (385 aa)
atf3-2MGC81814 protein. (181 aa)
fos-2MGC80305 protein. (368 aa)
atf5.2Atf5-prov protein. (308 aa)
adipoq-2MGC84292 protein. (235 aa)
pik3r1MGC80357 protein. (722 aa)
mycTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
hif1aHif1a-prov protein. (802 aa)
adipor1-2Adipor1-prov protein. (381 aa)
actl6aBaf53a-pending-prov protein; Belongs to the actin family. (429 aa)
hdac1-2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
hrasSmall G-protein H-Ras. (189 aa)
A0A1L8G8Y0Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
adipoqC1q domain-containing protein. (233 aa)
A0A1L8G2V6Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (467 aa)
Tnfaip3.SUncharacterized protein. (781 aa)
atf3BZIP domain-containing protein. (182 aa)
A0A1L8FW11Uncharacterized protein. (139 aa)
Scin.LUncharacterized protein. (714 aa)
A0A1L8FVW9Uncharacterized protein. (715 aa)
Myc.SMyc_N domain-containing protein. (176 aa)
Bcl2.SBH4_2 domain-containing protein. (253 aa)
A0A1L8FR37Uncharacterized protein. (682 aa)
A0A1L8FQH6Uncharacterized protein. (184 aa)
Apoa5.LUncharacterized protein. (343 aa)
krasUncharacterized protein. (186 aa)
apoa5Uncharacterized protein. (343 aa)
Txnip.LArrestin_C domain-containing protein. (388 aa)
psen1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (433 aa)
tgfb1-2Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
irs4Uncharacterized protein. (1077 aa)
hspa5Uncharacterized protein; Belongs to the heat shock protein 70 family. (658 aa)
gsnUncharacterized protein. (730 aa)
txnipArrestin_C domain-containing protein. (388 aa)
gata1Uncharacterized protein. (367 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
Irs4.SUncharacterized protein. (1088 aa)
A0A1L8EZY9Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (433 aa)
Hdac4.LHistone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1171 aa)
ube2cUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1016 aa)
stat3.1Signal transducer and activator of transcription. (769 aa)
hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
Hdac5.SHistone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1048 aa)
thibzLeucine zipper. (331 aa)
kras-3LOC397771 protein. (186 aa)
rps6ka3Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (737 aa)
c-JunC-Jun protein; Belongs to the bZIP family. (312 aa)
pax6Uncharacterized protein. (467 aa)
mafBZIP domain-containing protein; Belongs to the bZIP family. (344 aa)
Hmox1.SUncharacterized protein. (288 aa)
pax6-2Uncharacterized protein. (467 aa)
maf-2BZIP domain-containing protein; Belongs to the bZIP family. (351 aa)
Jun.LBZIP domain-containing protein; Belongs to the bZIP family. (314 aa)
A0A1L8GM23Uncharacterized protein. (1150 aa)
hmox1Uncharacterized protein. (287 aa)
RTCBRNA-splicing ligase RtcB homolog; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. (505 aa)
Hdac3.SHistone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (405 aa)
egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (497 aa)
lepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
Tp53.LP53 domain-containing protein. (137 aa)
A0A1L8H929Uncharacterized protein. (1008 aa)
tnfsf11TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (290 aa)
hdac7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (972 aa)
dgat2Uncharacterized protein. (361 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
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