90 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	tbxt	Uncharacterized protein. (432 aa)
	erbb3-2	Protein kinase domain-containing protein. (1347 aa)
	cnpy2	Saposin B-type domain-containing protein. (184 aa)
	spry2	Uncharacterized protein. (307 aa)
	nf1	Uncharacterized protein. (2759 aa)
	Cblb.L	Uncharacterized protein. (978 aa)
	lrig2	Uncharacterized protein. (1075 aa)
	anos1-2	Uncharacterized protein. (682 aa)
	erbb3	Protein kinase domain-containing protein. (1331 aa)
	Cblb.S	Uncharacterized protein. (979 aa)
	anos1	Uncharacterized protein. (679 aa)
	fgfr1-2	Fibroblast growth factor receptor. (812 aa)
	igf1r	Tyrosine-protein kinase receptor. (1358 aa)
	hgf-2	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
	lrig3-2	Uncharacterized protein. (1106 aa)
	frs2	IRS-type PTB domain-containing protein. (518 aa)
	socs2	Uncharacterized protein. (201 aa)
	Hsp90b1.L	HATPase_c domain-containing protein. (843 aa)
	spry4-2	Uncharacterized protein. (297 aa)
	spry4	Uncharacterized protein. (297 aa)
	lrig3	Uncharacterized protein. (1107 aa)
	hgf	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
	pik3cg	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1115 aa)
	map2k1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)
	fgfr1	Fibroblast growth factor receptor. (810 aa)
	Rtn3.L	Reticulon. (206 aa)
	RTN3	Reticulon. (214 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	pik3cb-2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	spred2-2	Uncharacterized protein. (409 aa)
	cnpy3	DUF3456 domain-containing protein. (243 aa)
	rtn4-2	Reticulon. (1024 aa)
	pik3cb	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	Epha4.L	Uncharacterized protein. (1022 aa)
	tfcp2	Uncharacterized protein. (506 aa)
	rtn4	Reticulon. (1043 aa)
	spred2	Uncharacterized protein. (412 aa)
	Flrt3.S	Fibronectin type-III domain-containing protein. (648 aa)
	egfr-2	Receptor protein-tyrosine kinase. (1210 aa)
	etv4	ETS domain-containing protein. (477 aa)
	cnpy1-2	DUF3456 domain-containing protein. (182 aa)
	socs6	Uncharacterized protein. (533 aa)
	egfr	Receptor protein-tyrosine kinase. (1208 aa)
	cnpy1	DUF3456 domain-containing protein. (182 aa)
	A0A1L8FND1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
	cbl	Uncharacterized protein. (887 aa)
	hpse2	Uncharacterized protein. (578 aa)
	Errfi1.S	Inhibitor_Mig-6 domain-containing protein. (404 aa)
	Spred1.L	Uncharacterized protein. (405 aa)
	shisa1.1	Uncharacterized protein. (269 aa)
	rtn2-2	Reticulon. (321 aa)
	ptpn21	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1181 aa)
	Rtn1.L	Reticulon. (768 aa)
	flrt2-2	Uncharacterized protein. (666 aa)
	otx2-2	Homeobox domain-containing protein. (289 aa)
	grb2	Uncharacterized protein. (229 aa)
	Fn1.S	Uncharacterized protein. (2480 aa)
	erbb2	Receptor protein-tyrosine kinase. (1299 aa)
	grb2-2	Uncharacterized protein. (229 aa)
	Ptpn18.S	Uncharacterized protein. (511 aa)
	otx2	Homeobox domain-containing protein. (288 aa)
	Rtn1.S	Reticulon. (752 aa)
	flrt2	Uncharacterized protein. (691 aa)
	rtn2	Reticulon. (322 aa)
	Ptpn11.S	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
	dusp6	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (378 aa)
	spry2-2	LOC398313 protein. (314 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	epha4	Pag protein. (986 aa)
	hif1a	Hif1a-prov protein. (802 aa)
	errfi1	MGC68521 protein. (401 aa)
	stat5b	Signal transducer and activator of transcription. (781 aa)
	tbxt-2	MGC81453 protein. (432 aa)
	cnpy2-2	MGC80474 protein. (184 aa)
	ptpn11b	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	socs6-2	Socs6-prov protein. (533 aa)
	flrt3	LOC503672 protein. (648 aa)
	socs2-2	MGC84938 protein. (202 aa)
	src	Tyrosine-protein kinase. (532 aa)
	vegfa	Vascular endothelial growth factor 196; Belongs to the PDGF/VEGF growth factor family. (194 aa)
	socs1	Suppressor of cytokine signaling. (211 aa)
	LOC398022	Tyrosine-protein kinase receptor. (1363 aa)
	ins-2	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	spry1-2	Sprouty 1. (319 aa)
	Cbl.S	Uncharacterized protein. (945 aa)
	spry1	Uncharacterized protein. (342 aa)
	Kit.L	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
	Fgfr3.L	Fibroblast growth factor receptor. (821 aa)
	Nedd4l.S	Uncharacterized protein. (979 aa)
	Kit.S	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (963 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FND1	Fgfr3.L	A0A1L8FND1	A0A1L8HT17	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Fibroblast growth factor receptor.	0.755
A0A1L8FND1	Fn1.S	A0A1L8FND1	A0A1L8EPN8	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.502
A0A1L8FND1	Kit.L	A0A1L8FND1	A0A1L8HTR4	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.789
A0A1L8FND1	Kit.S	A0A1L8FND1	A0A1L8HL85	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.789
A0A1L8FND1	LOC398022	A0A1L8FND1	B7ZSL0	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase receptor.	0.994
A0A1L8FND1	Nedd4l.S	A0A1L8FND1	A0A1L8HRV4	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.550
A0A1L8FND1	egfr	A0A1L8FND1	A0A1L8FRS8	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Receptor protein-tyrosine kinase.	0.876
A0A1L8FND1	egfr-2	A0A1L8FND1	A0A1L8FWP8	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Receptor protein-tyrosine kinase.	0.876
A0A1L8FND1	erbb2	A0A1L8FND1	A0A1L8ES20	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Receptor protein-tyrosine kinase.	0.795
A0A1L8FND1	erbb3	A0A1L8FND1	A0A1L8H9M6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Protein kinase domain-containing protein.	0.774
A0A1L8FND1	erbb3-2	A0A1L8FND1	A0A1L8HI31	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Protein kinase domain-containing protein.	0.774
A0A1L8FND1	fgf8	A0A1L8FND1	Q8AXC5	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.432
A0A1L8FND1	fgfr1	A0A1L8FND1	A0A1L8GRK9	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Fibroblast growth factor receptor.	0.793
A0A1L8FND1	fgfr1-2	A0A1L8FND1	A0A1L8H273	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Fibroblast growth factor receptor.	0.793
A0A1L8FND1	grb2	A0A1L8FND1	A0A1L8EMZ6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.722
A0A1L8FND1	grb2-2	A0A1L8FND1	A0A1L8EUF2	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.722
A0A1L8FND1	hgf	A0A1L8FND1	A0A1L8GTY1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.613
A0A1L8FND1	hgf-2	A0A1L8FND1	A0A1L8GZD1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.613
A0A1L8FND1	hif1a	A0A1L8FND1	Q6PI54	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Hif1a-prov protein.	0.554
A0A1L8FND1	igf1r	A0A1L8FND1	A0A1L8H104	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase receptor.	0.994