31 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fyn-2	Tyrosine-protein kinase. (537 aa)
	fzd2	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
	smurf2	E3 ubiquitin-protein ligase. (751 aa)
	stat3.1	Signal transducer and activator of transcription. (769 aa)
	fzd7	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (549 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	vangl2	Vang-like protein. (521 aa)
	wnt11b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	vangl2-2	Vang-like protein. (521 aa)
	Arhgap21.S	Uncharacterized protein. (1925 aa)
	Arhgap21.L	Uncharacterized protein. (1786 aa)
	snai2	Uncharacterized protein. (266 aa)
	Esr1.S	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	fyn	Tyrosine-protein kinase. (537 aa)
	Prkci.L	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (588 aa)
	Jun.L	BZIP domain-containing protein; Belongs to the bZIP family. (314 aa)
	Wnt5b.S	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (375 aa)
	prickle1	Uncharacterized protein. (835 aa)
	vangl1	Vang-like protein. (503 aa)
	vangl1-2	Vang-like protein. (499 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	cdh11-2	Cadherin; Cadherins are calcium-dependent cell adhesion proteins. (794 aa)
	rac1	MGC114731 protein. (192 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	mink1	Misshapen/Nck interacting Kinase. (1270 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	rhoa	MGC64296 protein. (193 aa)
	actl6a	Baf53a-pending-prov protein; Belongs to the actin family. (429 aa)
	snai2-2	Zinc finger transcription factor slug beta. (266 aa)
	c-Jun	C-Jun protein; Belongs to the bZIP family. (312 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Arhgap21.L	prickle1	A0A1L8FVK0	A0A1L8GUA2	Uncharacterized protein.	Uncharacterized protein.	0.532
Arhgap21.L	rac1	A0A1L8FVK0	Q58E25	Uncharacterized protein.	MGC114731 protein.	0.502
Arhgap21.L	rhoa	A0A1L8FVK0	Q7SZA9	Uncharacterized protein.	MGC64296 protein.	0.611
Arhgap21.L	smurf2	A0A1L8FVK0	A0A1L8ENB0	Uncharacterized protein.	E3 ubiquitin-protein ligase.	0.480
Arhgap21.S	prickle1	A0A1L8FQS3	A0A1L8GUA2	Uncharacterized protein.	Uncharacterized protein.	0.534
Arhgap21.S	rac1	A0A1L8FQS3	Q58E25	Uncharacterized protein.	MGC114731 protein.	0.503
Arhgap21.S	rhoa	A0A1L8FQS3	Q7SZA9	Uncharacterized protein.	MGC64296 protein.	0.612
Arhgap21.S	smurf2	A0A1L8FQS3	A0A1L8ENB0	Uncharacterized protein.	E3 ubiquitin-protein ligase.	0.522
Esr1.S	Jun.L	A0A1L8G265	A0A1L8GLZ4	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	BZIP domain-containing protein; Belongs to the bZIP family.	0.913
Esr1.S	actl6a	A0A1L8G265	Q7ZYI5	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Baf53a-pending-prov protein; Belongs to the actin family.	0.686
Esr1.S	c-Jun	A0A1L8G265	Q9PVZ1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	C-Jun protein; Belongs to the bZIP family.	0.914
Esr1.S	ctnnb1	A0A1L8G265	Q63ZT4	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Beta-catenin protein.	0.759
Esr1.S	stat3.1	A0A1L8G265	A0A1L8ERT1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Signal transducer and activator of transcription.	0.709
Jun.L	Esr1.S	A0A1L8GLZ4	A0A1L8G265	BZIP domain-containing protein; Belongs to the bZIP family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.913
Jun.L	Wnt5b.S	A0A1L8GLZ4	A0A1L8GQS0	BZIP domain-containing protein; Belongs to the bZIP family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.429
Jun.L	actl6a	A0A1L8GLZ4	Q7ZYI5	BZIP domain-containing protein; Belongs to the bZIP family.	Baf53a-pending-prov protein; Belongs to the actin family.	0.699
Jun.L	c-Jun	A0A1L8GLZ4	Q9PVZ1	BZIP domain-containing protein; Belongs to the bZIP family.	C-Jun protein; Belongs to the bZIP family.	0.958
Jun.L	cdh11-2	A0A1L8GLZ4	O93264	BZIP domain-containing protein; Belongs to the bZIP family.	Cadherin; Cadherins are calcium-dependent cell adhesion proteins.	0.428
Jun.L	ctnnb1	A0A1L8GLZ4	Q63ZT4	BZIP domain-containing protein; Belongs to the bZIP family.	Beta-catenin protein.	0.936
Jun.L	esr1	A0A1L8GLZ4	Q6W5G7	BZIP domain-containing protein; Belongs to the bZIP family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.913