STRINGSTRING
twist1 twist1 pdk4 pdk4 Pfkp.S Pfkp.S Cdc25a.S Cdc25a.S prmt1-2 prmt1-2 hhex-2 hhex-2 Cdk1.L Cdk1.L pdcd4 pdcd4 Casp9.S Casp9.S kras kras prmt1 prmt1 hhex hhex cdk1 cdk1 nes-2 nes-2 Setdb1.L Setdb1.L tgfb1-2 tgfb1-2 Foxo4.L Foxo4.L notch1 notch1 taz taz nes nes setdb1 setdb1 tgfb1 tgfb1 foxo4 foxo4 Notch1.S Notch1.S A0A1L8EY07 A0A1L8EY07 jmjd6-2 jmjd6-2 aurka aurka stat3.1 stat3.1 Zeb2.S Zeb2.S h3f3b h3f3b jmjd6 jmjd6 e2f1 e2f1 Sox2.S Sox2.S pcna pcna Ccnb1.S Ccnb1.S kras-3 kras-3 snai2-2 snai2-2 prkaa2 prkaa2 hras hras ccnd1 ccnd1 hdac1-2 hdac1-2 pdk4-2 pdk4-2 ctnnb1-2 ctnnb1-2 hspa9 hspa9 myc myc kras-2 kras-2 ogt ogt ctnnb1 ctnnb1 slc2a1 slc2a1 bdnf-2 bdnf-2 prkaa1 prkaa1 krasl krasl dhfr dhfr myf6 myf6 ccnd2-2 ccnd2-2 prmt5 prmt5 XMyf-5 XMyf-5 ccnd2 ccnd2 mycn mycn egln3 egln3 twist1-2 twist1-2 abcg2-2 abcg2-2 pten pten e2f1-2 e2f1-2 Igf2bp3.S Igf2bp3.S A0A310TTQ1 A0A310TTQ1 ccnb1 ccnb1 apc-2 apc-2 Gadd45g.L Gadd45g.L gas1-2 gas1-2 Casp3.L Casp3.L Phox2b Phox2b nsd2 nsd2 apc apc msi1 msi1 Nf2.S Nf2.S ndrg2 ndrg2 Prmt5.S Prmt5.S gas1 gas1 abcg2 abcg2 casp3.2 casp3.2 Phox2b.S Phox2b.S Nsd2.S Nsd2.S Fut4.L Fut4.L hdac1 hdac1 Cdk4.L Cdk4.L yap1 yap1 Cdk2.S Cdk2.S rb1 rb1 Kdm6a.S Kdm6a.S Tp53.L Tp53.L Kdm6b.L Kdm6b.L Dnmt1.L Dnmt1.L fgfr1-2 fgfr1-2 hgf-2 hgf-2 Hdac3.S Hdac3.S Cdc25c1 Cdc25c1 myf5 myf5 hgf hgf fgfr1 fgfr1 Cdkn1b.S Cdkn1b.S Ccnb1 Ccnb1 ccne1 ccne1 cdh3 cdh3 cdh1 cdh1 igf2-2 igf2-2 Myod1.L Myod1.L A0A1L8GGU0 A0A1L8GGU0 ccnb1.2 ccnb1.2 Ccne1.S Ccne1.S Cdh1.S Cdh1.S bdnf bdnf igf2 igf2 Mycn.S Mycn.S hist2h3c hist2h3c sox17b.1-2 sox17b.1-2 snai2 snai2 Cdh2.L Cdh2.L twsg1-2 twsg1-2 ezh2 ezh2 igf2bp3 igf2bp3 Abcb1.L Abcb1.L Zeb1.S Zeb1.S sox17b.1 sox17b.1 Sox17a.S Sox17a.S cdh2 cdh2 twsg1 twsg1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
twist1BHLH domain-containing protein. (166 aa)
pdk4Protein-serine/threonine kinase. (404 aa)
Pfkp.SATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (794 aa)
Cdc25a.SRhodanese domain-containing protein. (172 aa)
prmt1-2Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (351 aa)
hhex-2Homeobox domain-containing protein. (272 aa)
Cdk1.LProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (333 aa)
pdcd4Uncharacterized protein. (455 aa)
Casp9.SUncharacterized protein; Belongs to the peptidase C14A family. (399 aa)
krasUncharacterized protein. (186 aa)
prmt1Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (351 aa)
hhexHomeobox domain-containing protein. (276 aa)
cdk1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
nes-2IF rod domain-containing protein; Belongs to the intermediate filament family. (1954 aa)
Setdb1.LUncharacterized protein. (1343 aa)
tgfb1-2Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
Foxo4.LFork-head domain-containing protein. (485 aa)
notch1Uncharacterized protein. (2521 aa)
tazTafazzin family protein; Belongs to the taffazin family. (262 aa)
nesIF rod domain-containing protein; Belongs to the intermediate filament family. (1875 aa)
setdb1Uncharacterized protein. (1290 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
foxo4Fork-head domain-containing protein. (492 aa)
Notch1.SUncharacterized protein. (2524 aa)
A0A1L8EY07Histone H3; Belongs to the histone H3 family. (120 aa)
jmjd6-2JmjC domain-containing protein. (403 aa)
aurkaProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (407 aa)
stat3.1Signal transducer and activator of transcription. (769 aa)
Zeb2.SUncharacterized protein. (1246 aa)
h3f3bHistone H3; Belongs to the histone H3 family. (136 aa)
jmjd6JmjC domain-containing protein. (403 aa)
e2f1E2F_TDP domain-containing protein. (427 aa)
Sox2.SHMG box domain-containing protein. (194 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
Ccnb1.SCyclin B4; Belongs to the cyclin family. (393 aa)
kras-3LOC397771 protein. (186 aa)
snai2-2Zinc finger transcription factor slug beta. (266 aa)
prkaa2Non-specific serine/threonine protein kinase. (560 aa)
hrasSmall G-protein H-Ras. (189 aa)
ccnd1Ccnd1-prov protein; Belongs to the cyclin family. (291 aa)
hdac1-2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
pdk4-2Protein-serine/threonine kinase. (404 aa)
ctnnb1-2Ctnnb1-prov protein. (781 aa)
hspa9MGC52616 protein; Belongs to the heat shock protein 70 family. (670 aa)
mycTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
kras-2Uncharacterized protein. (187 aa)
ogtOgt-prov protein. (1063 aa)
ctnnb1Beta-catenin protein. (781 aa)
slc2a1LOC494763 protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (491 aa)
bdnf-2Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (247 aa)
prkaa1Non-specific serine/threonine protein kinase. (560 aa)
kraslUncharacterized protein. (187 aa)
dhfrLOC495375 protein; Belongs to the dihydrofolate reductase family. (189 aa)
myf6Myogenic factor. (241 aa)
ccnd2-2MGC132398 protein; Belongs to the cyclin family. (291 aa)
prmt5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (633 aa)
XMyf-5Myogenic factor. (255 aa)
ccnd2Cyclin D2; Belongs to the cyclin family. (291 aa)
mycnBHLH domain-containing protein. (437 aa)
egln3LOC100127282 protein. (252 aa)
twist1-2LOC100036981 protein. (166 aa)
abcg2-2LOC100036892 protein. (661 aa)
ptenPhosphatase and tensin homolog S homeolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
e2f1-2LOC100036852 protein. (426 aa)
Igf2bp3.SUncharacterized protein. (593 aa)
A0A310TTQ1Histone H3; Belongs to the histone H3 family. (136 aa)
ccnb1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (390 aa)
apc-2Uncharacterized protein. (2834 aa)
Gadd45g.LRibosomal_L7Ae domain-containing protein. (237 aa)
gas1-2Uncharacterized protein. (284 aa)
Casp3.LUncharacterized protein; Belongs to the peptidase C14A family. (253 aa)
Phox2bHomeobox domain-containing protein. (293 aa)
nsd2Uncharacterized protein. (1300 aa)
apcUncharacterized protein. (2827 aa)
msi1Uncharacterized protein. (340 aa)
Nf2.SFERM domain-containing protein. (584 aa)
ndrg2Uncharacterized protein. (454 aa)
Prmt5.SProtein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (633 aa)
gas1Uncharacterized protein. (299 aa)
abcg2ABC transporter domain-containing protein. (661 aa)
casp3.2Uncharacterized protein; Belongs to the peptidase C14A family. (288 aa)
Phox2b.SHomeobox domain-containing protein. (293 aa)
Nsd2.SUncharacterized protein. (1300 aa)
Fut4.LGlyco_tran_10_N domain-containing protein. (363 aa)
hdac1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
Cdk4.LProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (348 aa)
yap1Uncharacterized protein. (457 aa)
Cdk2.SProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
rb1Uncharacterized protein. (899 aa)
Kdm6a.SUncharacterized protein. (1455 aa)
Tp53.LP53 domain-containing protein. (137 aa)
Kdm6b.LJmjC domain-containing protein. (1763 aa)
Dnmt1.LDNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1488 aa)
fgfr1-2Fibroblast growth factor receptor. (812 aa)
hgf-2Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
Hdac3.SHistone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (405 aa)
Cdc25c1Rhodanese domain-containing protein. (550 aa)
myf5Myogenic factor. (255 aa)
hgfHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
fgfr1Fibroblast growth factor receptor. (810 aa)
Cdkn1b.SUncharacterized protein. (152 aa)
Ccnb1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (397 aa)
ccne1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (408 aa)
cdh3Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
cdh1Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (871 aa)
igf2-2IlGF domain-containing protein. (217 aa)
Myod1.LMyogenic factor. (289 aa)
A0A1L8GGU0Uncharacterized protein. (2447 aa)
ccnb1.2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (397 aa)
Ccne1.SCyclin N-terminal domain-containing protein; Belongs to the cyclin family. (408 aa)
Cdh1.SUncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (914 aa)
bdnfBrain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (247 aa)
igf2IlGF domain-containing protein. (217 aa)
Mycn.SBHLH domain-containing protein. (439 aa)
hist2h3cHistone H3; Belongs to the histone H3 family. (136 aa)
sox17b.1-2Uncharacterized protein. (373 aa)
snai2Uncharacterized protein. (266 aa)
Cdh2.LUncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
twsg1-2Uncharacterized protein. (218 aa)
ezh2Uncharacterized protein. (748 aa)
igf2bp3Uncharacterized protein. (594 aa)
Abcb1.LUncharacterized protein. (1286 aa)
Zeb1.SUncharacterized protein. (919 aa)
sox17b.1Uncharacterized protein. (373 aa)
Sox17a.SUncharacterized protein. (377 aa)
cdh2Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (947 aa)
twsg1Uncharacterized protein. (216 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
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