STRINGSTRING
Dna2.S Dna2.S mcm6.2 mcm6.2 sumo2 sumo2 h3f3b h3f3b Orc2.S Orc2.S Sumo1.S Sumo1.S usp7 usp7 Cdc6.L Cdc6.L Dbf4b.L Dbf4b.L top1.1 top1.1 Sumo1.L Sumo1.L usp7-2 usp7-2 A0A1L8EY07 A0A1L8EY07 slx4 slx4 Exo1.S Exo1.S Endog.L Endog.L smc3 smc3 lig1 lig1 mcm4 mcm4 dbf4 dbf4 mcm6 mcm6 Mcm4.S Mcm4.S Rad21.L Rad21.L Nsmce2.L Nsmce2.L hist2h3c hist2h3c Senp6.S Senp6.S Znf451.L Znf451.L Smc6.L Smc6.L Ccne1.S Ccne1.S top1.2 top1.2 mcm2 mcm2 ccne1 ccne1 uba2 uba2 Orc1.L Orc1.L fancd2 fancd2 Mcm2.L Mcm2.L Rad52.S Rad52.S pias1 pias1 fanci fanci Pias1.L Pias1.L Senp1.S Senp1.S Senp1.L Senp1.L smc5 smc5 Rnf4-a Rnf4-a pkd2 pkd2 cdc45 cdc45 A0A310TTQ1 A0A310TTQ1 rnf4 rnf4 rad21 rad21 top2a top2a prim1 prim1 pcna pcna
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Dna2.SUncharacterized protein. (1053 aa)
mcm6.2DNA helicase; Belongs to the MCM family. (825 aa)
sumo2Small ubiquitin-related modifier. (95 aa)
h3f3bHistone H3; Belongs to the histone H3 family. (136 aa)
Orc2.SUncharacterized protein. (558 aa)
Sumo1.SUbiquitin-like domain-containing protein. (141 aa)
usp7Uncharacterized protein; Belongs to the peptidase C19 family. (1123 aa)
Cdc6.LCell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (645 aa)
Dbf4b.LDBF4-type domain-containing protein. (784 aa)
top1.1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (821 aa)
Sumo1.LUbiquitin-like domain-containing protein. (148 aa)
usp7-2Usp7; Belongs to the peptidase C19 family. (1124 aa)
A0A1L8EY07Histone H3; Belongs to the histone H3 family. (120 aa)
slx4BTB domain-containing protein. (1773 aa)
Exo1.SUncharacterized protein. (734 aa)
Endog.LEndonuclease. (290 aa)
smc3Structural maintenance of chromosomes protein. (1209 aa)
lig1DNA ligase. (1062 aa)
mcm4DNA helicase; Belongs to the MCM family. (858 aa)
dbf4Uncharacterized protein. (661 aa)
mcm6DNA helicase; Belongs to the MCM family. (821 aa)
Mcm4.SDNA helicase; Belongs to the MCM family. (863 aa)
Rad21.LUncharacterized protein. (629 aa)
Nsmce2.LSP-RING-type domain-containing protein. (238 aa)
hist2h3cHistone H3; Belongs to the histone H3 family. (136 aa)
Senp6.SULP_PROTEASE domain-containing protein. (1103 aa)
Znf451.LUncharacterized protein. (1207 aa)
Smc6.LSMC_N domain-containing protein. (1128 aa)
Ccne1.SCyclin N-terminal domain-containing protein; Belongs to the cyclin family. (408 aa)
top1.2DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (770 aa)
mcm2DNA helicase; Belongs to the MCM family. (885 aa)
ccne1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (408 aa)
uba2SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (641 aa)
Orc1.LOrigin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (886 aa)
fancd2Uncharacterized protein. (1445 aa)
Mcm2.LDNA helicase; Belongs to the MCM family. (886 aa)
Rad52.SUncharacterized protein. (429 aa)
pias1Uncharacterized protein. (640 aa)
fanciUncharacterized protein. (1337 aa)
Pias1.LUncharacterized protein. (649 aa)
Senp1.SULP_PROTEASE domain-containing protein. (546 aa)
Senp1.LULP_PROTEASE domain-containing protein. (616 aa)
smc5AAA_15 domain-containing protein. (1063 aa)
Rnf4-aRING-type domain-containing protein. (190 aa)
pkd2EF-hand domain-containing protein. (947 aa)
cdc45Uncharacterized protein. (567 aa)
A0A310TTQ1Histone H3; Belongs to the histone H3 family. (136 aa)
rnf4LOC495944 protein. (190 aa)
rad21LOC503676 protein. (629 aa)
top2aDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1579 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
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